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International Journal of Colorectal Disease

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01-06-2011 | Review

A literature review on the role of chemical sphincterotomy after Milligan–Morgan hemorrhoidectomy

Authors: Muhammad Rafay Sameem Siddiqui, Chuk Abraham-Igwe, Arun Shangumanandan, Veronica Grassi, Ian Swift, Al Mutaz Abulafi

Published in: International Journal of Colorectal Disease | Issue 6/2011

Abstract

Objective

A literature review of agents used to induce chemical sphincterotomy after hemorrhoidectomy.

Methods

Electronic databases were searched from January 1935 to August 2010.

Results

Two randomized controlled trials compared calcium channel blockers (Ca2) with placebo. Pain appeared to be less for up to 7 days, and its side-effect profile was comparable to the control group. Four randomized controlled trials examined the role of glyceryl trinitrate (GTN). GTN may be used up to 6 weeks to aid healing. Pain may be slightly less during its use and potentially offers less pain during defecation in the first 48 h. Its side-effect profile including headache appears comparable to placebo. Three randomized controlled trials investigated botulinum toxin A (BTX). BTX may be used to aid healing after hemorrhoidectomy. Pain may be less for up to a week after surgery. Its side-effect profile including incontinence to flatus appears comparable to placebo. It would be especially useful in cases where poor patient compliance is envisaged. Only one paper was found comparing BTX with GTN. BTX may be preferred over GTN due to better pain control and fewer side effects.

Conclusion

BTX, Ca2, and GTN may give effective pain relief for a week after hemorrhoidectomy. Their side-effect profiles are comparable to placebo.

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Title: A literature review on the role of chemical sphincterotomy after Milligan–Morgan hemorrhoidectomy
Authors: Muhammad Rafay Sameem Siddiqui
Chuk Abraham-Igwe
Arun Shangumanandan
Veronica Grassi
Ian Swift
Al Mutaz Abulafi
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 6/2011
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-010-1121-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A literature review on the role of chemical sphincterotomy after Milligan–Morgan hemorrhoidectomy

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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