Skip to main content
Top
Published in: Endocrine Pathology 2/2007

01-05-2007 | Case Report

A Large Sellar Granular Cell Tumor in a 21-year-old Woman

Authors: Vera Popovic, Sandra Pekic, Milica Skender-Gazibara, Fateme Salehi, Kalman Kovacs

Published in: Endocrine Pathology | Issue 2/2007

Login to get access

Abstract

We report here the case of a 21-year-old woman with a large sellar tumor, extending to the suprasellar area associated with growth hormone deficiency, hypogonadism, hypocorticism, and hyperprolactinemia. Transsphenoidal surgery was performed, and histologic, immunohistochemical, and electron microscopic study lead to the diagnosis of granular cell tumor. These tumors are, in most cases, very small and are found incidentally at autopsy of older patients. Our case is exceptional because the tumor developed in a young woman, extended to the suprasellar region, and caused clinical symptoms.
Literature
1.
go back to reference Barrande G, Kujas M, Gancel A, Turpin G, Bruckert E, Kuhn JM, Luton JP. Granular cell tumors. Rare tumors of the neurohypophysis. Presse Med 24:1376–80, 1995.PubMed Barrande G, Kujas M, Gancel A, Turpin G, Bruckert E, Kuhn JM, Luton JP. Granular cell tumors. Rare tumors of the neurohypophysis. Presse Med 24:1376–80, 1995.PubMed
2.
go back to reference DeLellis RA, Lloyd RV, Heitz PU, Eng C. World Health Organization classification of tumours, pathology and genetics, tumours of endocrine organs. Lyon: IARC Press, 2004. DeLellis RA, Lloyd RV, Heitz PU, Eng C. World Health Organization classification of tumours, pathology and genetics, tumours of endocrine organs. Lyon: IARC Press, 2004.
3.
go back to reference Schaller B, Kirsch E, Tolnay M, Mindermann T. Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 42:166–1701, 1998.PubMedCrossRef Schaller B, Kirsch E, Tolnay M, Mindermann T. Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 42:166–1701, 1998.PubMedCrossRef
4.
go back to reference Benites Filho PR, Sakamoto D, Machuca TN, Serapiao MJ, Ditzel L, Bleggi Torres LF. Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation. Virchows Arch 447:649–52, 2005.PubMedCrossRef Benites Filho PR, Sakamoto D, Machuca TN, Serapiao MJ, Ditzel L, Bleggi Torres LF. Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation. Virchows Arch 447:649–52, 2005.PubMedCrossRef
5.
go back to reference Abrikossoff A, Uber M. Ausgehend von der quergestreiften, willkurlichen Muskulatur. Virchows Arch Pathol Anat 260:215–33, 1926.CrossRef Abrikossoff A, Uber M. Ausgehend von der quergestreiften, willkurlichen Muskulatur. Virchows Arch Pathol Anat 260:215–33, 1926.CrossRef
6.
go back to reference Boyce R, Beadles CF. A further contribution to the study of the pathology of the hypophysis cerebri. J Pathol Bacteriol 1:359–83, 1893.CrossRef Boyce R, Beadles CF. A further contribution to the study of the pathology of the hypophysis cerebri. J Pathol Bacteriol 1:359–83, 1893.CrossRef
7.
go back to reference Ji CH, Teng MM, Chang T, Granular cell tumour of the neurohypophysis. Neuroradiology. 37:451–2, 1995.PubMed Ji CH, Teng MM, Chang T, Granular cell tumour of the neurohypophysis. Neuroradiology. 37:451–2, 1995.PubMed
8.
go back to reference Rickert CH, Kuchelmeister K, Gullotta F. Morphological and immunohistochemical characterization of granular cells in non-hypophyseal tumours of the central nervous system. Histopathology 30:464–71, 1997.PubMedCrossRef Rickert CH, Kuchelmeister K, Gullotta F. Morphological and immunohistochemical characterization of granular cells in non-hypophyseal tumours of the central nervous system. Histopathology 30:464–71, 1997.PubMedCrossRef
9.
go back to reference Kontogeorgos G, Scheithauer BW, Kovacs K, Horvath E, Melmed S. Growth factors and cytokines in paragangliomas and pheochromocytomas, with special reference to sustentacular cells. Endocr Pathol 13:197–206, 2002.PubMedCrossRef Kontogeorgos G, Scheithauer BW, Kovacs K, Horvath E, Melmed S. Growth factors and cytokines in paragangliomas and pheochromocytomas, with special reference to sustentacular cells. Endocr Pathol 13:197–206, 2002.PubMedCrossRef
10.
11.
go back to reference Losa M, Saeger W, Mortini P, Pandolfi C, Terreni MR, Taccagni G, Giovanelli M. Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. J Neurosurg 93:121–6, 2000.PubMedCrossRef Losa M, Saeger W, Mortini P, Pandolfi C, Terreni MR, Taccagni G, Giovanelli M. Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. J Neurosurg 93:121–6, 2000.PubMedCrossRef
Metadata
Title
A Large Sellar Granular Cell Tumor in a 21-year-old Woman
Authors
Vera Popovic
Sandra Pekic
Milica Skender-Gazibara
Fateme Salehi
Kalman Kovacs
Publication date
01-05-2007
Publisher
Humana Press Inc
Published in
Endocrine Pathology / Issue 2/2007
Print ISSN: 1046-3976
Electronic ISSN: 1559-0097
DOI
https://doi.org/10.1007/s12022-007-0013-9

Other articles of this Issue 2/2007

Endocrine Pathology 2/2007 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine