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Published in: BMC Medical Research Methodology 1/2009

Open Access 01-12-2009 | Research article

A labelled discrete choice experiment adds realism to the choices presented: preferences for surveillance tests for Barrett esophagus

Authors: Michelle E Kruijshaar, Marie-Louise Essink-Bot, Bas Donkers, Caspar WN Looman, Peter D Siersema, Ewout W Steyerberg

Published in: BMC Medical Research Methodology | Issue 1/2009

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Abstract

Background

Discrete choice experiments (DCEs) allow systematic assessment of preferences by asking respondents to choose between scenarios. We conducted a labelled discrete choice experiment with realistic choices to investigate patients' trade-offs between the expected health gains and the burden of testing in surveillance of Barrett esophagus (BE).

Methods

Fifteen choice scenarios were selected based on 2 attributes: 1) type of test (endoscopy and two less burdensome fictitious tests), 2) frequency of surveillance. Each test-frequency combination was associated with its own realistic decrease in risk of dying from esophageal adenocarcinoma. A conditional logit model was fitted.

Results

Of 297 eligible patients (155 BE and 142 with non-specific upper GI symptoms), 247 completed the questionnaire (84%). Patients preferred surveillance to no surveillance. Current surveillance schemes of once every 1–2 years were amongst the most preferred alternatives. Higher health gains were preferred over those with lower health gains, except when test frequencies exceeded once a year. For similar health gains, patients preferred video-capsule over saliva swab and least preferred endoscopy.

Conclusion

This first example of a labelled DCE using realistic scenarios in a healthcare context shows that such experiments are feasible. A comparison of labelled and unlabelled designs taking into account setting and research question is recommended.
Appendix
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Literature
1.
go back to reference Gyrd-Hansen D, Sogaard J: Analysing public preferences for cancer screening programmes. Health Econ. 2001, 10 (7): 617-34. 10.1002/hec.622.CrossRefPubMed Gyrd-Hansen D, Sogaard J: Analysing public preferences for cancer screening programmes. Health Econ. 2001, 10 (7): 617-34. 10.1002/hec.622.CrossRefPubMed
2.
go back to reference Drummond MF, O'Brien B, Stoddart GL, Torrance GW: Methods for the Economic evaluation of Health Care Programmes. 1997, Oxford: Oxford University Press Drummond MF, O'Brien B, Stoddart GL, Torrance GW: Methods for the Economic evaluation of Health Care Programmes. 1997, Oxford: Oxford University Press
3.
go back to reference Baltussen R, Stolk E, Chisholm D, Aikins M: Towards a multi-criteria approach for priority setting: an application to Ghana. Health Econ. 2006, 15 (7): 689-96. 10.1002/hec.1092.CrossRefPubMed Baltussen R, Stolk E, Chisholm D, Aikins M: Towards a multi-criteria approach for priority setting: an application to Ghana. Health Econ. 2006, 15 (7): 689-96. 10.1002/hec.1092.CrossRefPubMed
4.
5.
go back to reference Salkeld G, Solomon M, Butow P, Short L: Discrete-choice experiment to measure patient preferences for the surgical management of colorectal cancer. Br J Surg. 2005, 92 (6): 742-7. 10.1002/bjs.4917.CrossRefPubMed Salkeld G, Solomon M, Butow P, Short L: Discrete-choice experiment to measure patient preferences for the surgical management of colorectal cancer. Br J Surg. 2005, 92 (6): 742-7. 10.1002/bjs.4917.CrossRefPubMed
6.
go back to reference Sculpher M, Bryan S, Fry P, de Winter P, Payne H, Emberton M: Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment. Bmj. 2004, 328 (7436): 382-10.1136/bmj.37972.497234.44.CrossRefPubMedPubMedCentral Sculpher M, Bryan S, Fry P, de Winter P, Payne H, Emberton M: Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment. Bmj. 2004, 328 (7436): 382-10.1136/bmj.37972.497234.44.CrossRefPubMedPubMedCentral
8.
go back to reference de Bekker-Grob EW, Essink-Bot ML, Meerding WJ, Pols HA, Koes BW, Steyerberg EW: Patients' preferences for osteoporosis drug treatment: a discrete choice experiment. Osteoporos Int. 2008, 19 (7): 1029-37. 10.1007/s00198-007-0535-5.CrossRefPubMedPubMedCentral de Bekker-Grob EW, Essink-Bot ML, Meerding WJ, Pols HA, Koes BW, Steyerberg EW: Patients' preferences for osteoporosis drug treatment: a discrete choice experiment. Osteoporos Int. 2008, 19 (7): 1029-37. 10.1007/s00198-007-0535-5.CrossRefPubMedPubMedCentral
9.
go back to reference Huber J, Zwerina K: The importance of utility balance in efficient choice designs. Journal of Marketing Research. 1996, 33 (3): 307-17. 10.2307/3152127.CrossRef Huber J, Zwerina K: The importance of utility balance in efficient choice designs. Journal of Marketing Research. 1996, 33 (3): 307-17. 10.2307/3152127.CrossRef
10.
go back to reference Sampliner RE: Updated guidelines for the diagnosis, surveillance, and therapy of Barrett's esophagus. Am J Gastroenterol. 2002, 97 (8): 1888-95. 10.1111/j.1572-0241.2002.05910.x.CrossRefPubMed Sampliner RE: Updated guidelines for the diagnosis, surveillance, and therapy of Barrett's esophagus. Am J Gastroenterol. 2002, 97 (8): 1888-95. 10.1111/j.1572-0241.2002.05910.x.CrossRefPubMed
11.
go back to reference Kruijshaar ME, Kerkhof M, Siersema PD, Steyerberg EW, Homs MYV, Essink-Bot ML: The burden of upper gastrointestinal endoscopy in patients with Barrett's esophagus. Endoscopy. 2006, 38: 873-8. 10.1055/s-2006-944613.CrossRefPubMed Kruijshaar ME, Kerkhof M, Siersema PD, Steyerberg EW, Homs MYV, Essink-Bot ML: The burden of upper gastrointestinal endoscopy in patients with Barrett's esophagus. Endoscopy. 2006, 38: 873-8. 10.1055/s-2006-944613.CrossRefPubMed
12.
go back to reference Conio M, Blanchi S, Lapertosa G, Ferraris R, Sablich R, Marchi S, D'Onofrio V, Lacchin T, Iaquinto G, Missale G, Ravelli P, Cestari R, Benedetti G, Macrì G, Fiocca R, Munizzi F, Filiberti R: Long-term endoscopic surveillance of patients with Barrett's esophagus. Incidence of dysplasia and adenocarcinoma: a prospective study. Am J Gastroenterol. 2003, 98 (9): 1931-9. 10.1111/j.1572-0241.2003.07666.x.CrossRefPubMed Conio M, Blanchi S, Lapertosa G, Ferraris R, Sablich R, Marchi S, D'Onofrio V, Lacchin T, Iaquinto G, Missale G, Ravelli P, Cestari R, Benedetti G, Macrì G, Fiocca R, Munizzi F, Filiberti R: Long-term endoscopic surveillance of patients with Barrett's esophagus. Incidence of dysplasia and adenocarcinoma: a prospective study. Am J Gastroenterol. 2003, 98 (9): 1931-9. 10.1111/j.1572-0241.2003.07666.x.CrossRefPubMed
13.
go back to reference Cullen J, Schwartz MD, Lawrence WF, Selby JV, Mandelblatt JS: Short-term impact of cancer prevention and screening activities on quality of life. J Clin Oncol. 2004, 22 (5): 943-52. 10.1200/JCO.2004.05.191.CrossRefPubMed Cullen J, Schwartz MD, Lawrence WF, Selby JV, Mandelblatt JS: Short-term impact of cancer prevention and screening activities on quality of life. J Clin Oncol. 2004, 22 (5): 943-52. 10.1200/JCO.2004.05.191.CrossRefPubMed
14.
go back to reference Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS: Is there publication bias in the reporting of cancer risk in Barrett's esophagus?. Gastroenterology. 2000, 119 (2): 333-8. 10.1053/gast.2000.9302.CrossRefPubMed Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS: Is there publication bias in the reporting of cancer risk in Barrett's esophagus?. Gastroenterology. 2000, 119 (2): 333-8. 10.1053/gast.2000.9302.CrossRefPubMed
15.
go back to reference Burgh van der A, Dees J, Hop WC, van Blankenstein M: Oesophageal cancer is an uncommon cause of death in patients with Barrett's oesophagus. Gut. 1996, 39 (1): 5-8. 10.1136/gut.39.1.5.CrossRefPubMedPubMedCentral Burgh van der A, Dees J, Hop WC, van Blankenstein M: Oesophageal cancer is an uncommon cause of death in patients with Barrett's oesophagus. Gut. 1996, 39 (1): 5-8. 10.1136/gut.39.1.5.CrossRefPubMedPubMedCentral
16.
go back to reference Hage M, Siersema PD, van Dekken H, Steyerberg EW, Dees J, Kuipers EJ: Oesophageal cancer incidence and mortality in patients with long-segment Barrett's oesophagus after a mean follow-up of 12.7 years. Scand J Gastroenterol. 2004, 39 (12): 1175-9. 10.1080/00365520410003524.CrossRefPubMed Hage M, Siersema PD, van Dekken H, Steyerberg EW, Dees J, Kuipers EJ: Oesophageal cancer incidence and mortality in patients with long-segment Barrett's oesophagus after a mean follow-up of 12.7 years. Scand J Gastroenterol. 2004, 39 (12): 1175-9. 10.1080/00365520410003524.CrossRefPubMed
17.
go back to reference Chang JT, Katzka DA: Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma. Arch Intern Med. 2004, 164 (14): 1482-8. 10.1001/archinte.164.14.1482.CrossRefPubMed Chang JT, Katzka DA: Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma. Arch Intern Med. 2004, 164 (14): 1482-8. 10.1001/archinte.164.14.1482.CrossRefPubMed
18.
go back to reference Tytgat GN, Van Sandick JW, Lanschot JJ, Obertop H: Role of surveillance in intestinal metaplasia of the esophagus and gastroesophageal junction. World J Surg. 2003, 27 (9): 1021-5. 10.1007/s00268-003-7194-2.CrossRefPubMed Tytgat GN, Van Sandick JW, Lanschot JJ, Obertop H: Role of surveillance in intestinal metaplasia of the esophagus and gastroesophageal junction. World J Surg. 2003, 27 (9): 1021-5. 10.1007/s00268-003-7194-2.CrossRefPubMed
20.
go back to reference Craanen ME, Blok P, Meijer GA, Meuwissen SG: Surveillance in Barrett's oesophagus: a critical reappraisal. Scand J Gastroenterol Suppl. 2002, 4-8. 10.1080/003655202320621373. 236 Craanen ME, Blok P, Meijer GA, Meuwissen SG: Surveillance in Barrett's oesophagus: a critical reappraisal. Scand J Gastroenterol Suppl. 2002, 4-8. 10.1080/003655202320621373. 236
21.
go back to reference Kruijshaar ME, Siersema PD, Janssens ACJW, Kerkhof M, Steyerberg EW, Essink-Bot ML: Patients with Barrett esophagus perceive their risk of developing esophageal adenocarcinoma as low. Gastrointestinal Endoscopy. 2007, 65: 26-30. 10.1016/j.gie.2006.05.030.CrossRefPubMed Kruijshaar ME, Siersema PD, Janssens ACJW, Kerkhof M, Steyerberg EW, Essink-Bot ML: Patients with Barrett esophagus perceive their risk of developing esophageal adenocarcinoma as low. Gastrointestinal Endoscopy. 2007, 65: 26-30. 10.1016/j.gie.2006.05.030.CrossRefPubMed
22.
go back to reference Kerkhof M, Steyerberg EW, Kusters JG, Kuipers EJ, Siersema PD: Predicting presence of intestinal metaplasia and dysplasia in columnar-lined esophagus: a multivariate analysis. Endoscopy. 2007, 39 (9): 772-8. 10.1055/s-2007-966737.CrossRefPubMed Kerkhof M, Steyerberg EW, Kusters JG, Kuipers EJ, Siersema PD: Predicting presence of intestinal metaplasia and dysplasia in columnar-lined esophagus: a multivariate analysis. Endoscopy. 2007, 39 (9): 772-8. 10.1055/s-2007-966737.CrossRefPubMed
23.
go back to reference Kerkhof M, van Dekken H, Steyerberg EW, Meijer GA, Mulder AH, De Bruine A, Driessen A, ten Kate FJ, Kusters JG, Kuipers EJ, Siersema PD, CYBAR study group: Grading of dysplasia in Barrett's oesophagus: substnatial interobserver variation between general and gastrointestinal pathologists. Histopathology. 2007, 50 (7): 920-7. 10.1111/j.1365-2559.2007.02706.x.CrossRefPubMed Kerkhof M, van Dekken H, Steyerberg EW, Meijer GA, Mulder AH, De Bruine A, Driessen A, ten Kate FJ, Kusters JG, Kuipers EJ, Siersema PD, CYBAR study group: Grading of dysplasia in Barrett's oesophagus: substnatial interobserver variation between general and gastrointestinal pathologists. Histopathology. 2007, 50 (7): 920-7. 10.1111/j.1365-2559.2007.02706.x.CrossRefPubMed
24.
go back to reference Faivre J, Forman D, Esteve J, Gatta G: Survival of patients with oesophageal and gastric cancers in Europe. Eur J Cancer. 1998, 34 (14): 2167-75. 10.1016/S0959-8049(98)00329-3.CrossRefPubMed Faivre J, Forman D, Esteve J, Gatta G: Survival of patients with oesophageal and gastric cancers in Europe. Eur J Cancer. 1998, 34 (14): 2167-75. 10.1016/S0959-8049(98)00329-3.CrossRefPubMed
25.
go back to reference Pearmain D, Swanson J, Kroes E, Bradley M: Stated preferences techniques: a guide to practice. 1991, The Hague: Steer Davis Gleave and Hague Consulting Group Pearmain D, Swanson J, Kroes E, Bradley M: Stated preferences techniques: a guide to practice. 1991, The Hague: Steer Davis Gleave and Hague Consulting Group
26.
go back to reference Hall J, Fiebig DG, King MT, Hossain I, Louviere JJ: What influences participation in genetic carrier testing? Results from a discrete choice experiment. J Health Econ. 2006, 25 (3): 520-37. 10.1016/j.jhealeco.2005.09.002.CrossRefPubMed Hall J, Fiebig DG, King MT, Hossain I, Louviere JJ: What influences participation in genetic carrier testing? Results from a discrete choice experiment. J Health Econ. 2006, 25 (3): 520-37. 10.1016/j.jhealeco.2005.09.002.CrossRefPubMed
27.
go back to reference Carlsson F, Martinsson P: Design techniques for stated preference methods in health economics. Health Econ. 2003, 12 (4): 281-94. 10.1002/hec.729.CrossRefPubMed Carlsson F, Martinsson P: Design techniques for stated preference methods in health economics. Health Econ. 2003, 12 (4): 281-94. 10.1002/hec.729.CrossRefPubMed
28.
go back to reference Zwerina K, Huber J, Kuhfeld A: A general method for constructing efficient choice designs. 2005, (SAS technical notes TS772e): The SAS Institute Zwerina K, Huber J, Kuhfeld A: A general method for constructing efficient choice designs. 2005, (SAS technical notes TS772e): The SAS Institute
29.
go back to reference McFadden D: The choice theory approach to market research. Marketing Science. 1986, 5 (4): 275-97. 10.1287/mksc.5.4.275.CrossRef McFadden D: The choice theory approach to market research. Marketing Science. 1986, 5 (4): 275-97. 10.1287/mksc.5.4.275.CrossRef
30.
go back to reference So Y, WF K: Multinomial Logit Models. 2005, (SAS technical notes TS772g): The SAS Institute So Y, WF K: Multinomial Logit Models. 2005, (SAS technical notes TS772g): The SAS Institute
31.
go back to reference Gyrd-Hansen D, Kristiansen IS, Nexoe J, Nielsen JB: Effects of baseline risk information on social and individual choices. Med Decis Making. 2002, 22 (1): 71-5.CrossRefPubMed Gyrd-Hansen D, Kristiansen IS, Nexoe J, Nielsen JB: Effects of baseline risk information on social and individual choices. Med Decis Making. 2002, 22 (1): 71-5.CrossRefPubMed
32.
go back to reference Slovic P: The construction of preference. American Psychologist. 1995, 50: 364-71. 10.1037/0003-066X.50.5.364.CrossRef Slovic P: The construction of preference. American Psychologist. 1995, 50: 364-71. 10.1037/0003-066X.50.5.364.CrossRef
Metadata
Title
A labelled discrete choice experiment adds realism to the choices presented: preferences for surveillance tests for Barrett esophagus
Authors
Michelle E Kruijshaar
Marie-Louise Essink-Bot
Bas Donkers
Caspar WN Looman
Peter D Siersema
Ewout W Steyerberg
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Medical Research Methodology / Issue 1/2009
Electronic ISSN: 1471-2288
DOI
https://doi.org/10.1186/1471-2288-9-31

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