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01-01-2011 | Short Communication

A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles

Authors: Isao Yuasa, Yoshito Irizawa, Hiroaki Nishimukai, Yasuo Fukumori, Kazuo Umetsu, Nori Nakayashiki, Naruya Saitou, Lotte Henke, Jürgen Henke

Published in: International Journal of Legal Medicine | Issue 1/2011

Abstract

In this study, a short tandem repeat (STR) polymorphism in intron 7 of the human complement factor I (CFI) gene was studied in 637 DNA samples obtained from African, German, Thai, and Japanese populations and German and Japanese families. A total of 41 alleles were observed and classified into two groups, L and H, based on size differences. Group H, which consisted of 16 alleles, was observed only in Thai and Japanese populations at frequencies of 0.162 and 0.116, respectively, and was strongly associated with c.1217A in exon 11 (CFI*Ah). The heterozygosity values ranged from 0.89 in German to 0.93 in Thai populations. This STR would be a useful supplementary marker for forensic individualization.

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Title: A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles
Authors: Isao Yuasa
Yoshito Irizawa
Hiroaki Nishimukai
Yasuo Fukumori
Kazuo Umetsu
Nori Nakayashiki
Naruya Saitou
Lotte Henke
Jürgen Henke
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: International Journal of Legal Medicine / Issue 1/2011
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-009-0369-0

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A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles

Abstract

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Abstract

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