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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2017

Open Access 01-12-2017 | Case report

A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

Authors: Nan Jia, Yan Chen, Xiang Tao, Enzhi Ou, Xin Lu, Weiwei Feng

Published in: Journal of Ovarian Research | Issue 1/2017

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Abstract

Background

Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to identify the presence of paternal DNA by DNA polymorphic analysis.

Case presentation

In the present case, a 27-year-old patient with a history of amenorrhea, lower abdominal pain and vaginal bleeding received a laparoscopic dissection of cystic mass of the right ovary according to an initial diagnosis of ectopic pregnancy. Primary choriocarcinoma of the ovary was diagnosed by pathology, but its origin was uncertain. DNA polymorphic analysis was then performed and a gestational origin was confirmed. The patient subsequently exhibited an excellent response to chemotherapy, achieved complete remission and gave birth to a healthy baby.

Conclusion

Differentiation between two etiologies of primary choriocarcinoma can be achieved with DNA polymorphic analysis and it is necessary to distinguish between them to approach to an appropriate treatment of a patient.
Literature
1.
Axe SR, Klein VR, Woodruff JD. Choriocarcinoma of the ovary. Obstet Gynecol. 1985;66:111–4.PubMed
2.
3.
Saito M, Azuma T, Nakamura K. On ectopic choriocarcinoma. World Obstet Gynecol. 1963;17:459–84.
4.
Kong B, Tian YJ, Zhu WW, Qin YJ. A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: case report and literature review. J Obstet Gynaecol res. 2009;35:574–8.CrossRefPubMed
5.
Vance RP, Geisinger KR. Pure nongestational choriocarcinoma of the ovary: report of a case. Cancer. 1985;56:2321–5.CrossRefPubMed
6.
7.
Sengupta SK, Everett VJ. Ovarian neoplasms in children and adolescents in Papua New Guinea. Aust N Z J Obstet Gynaecol. 1987;27:335–8.CrossRefPubMed
8.
Gribbon M, Ein SH, Mancer K. Pediatric malignant ovarian tumors: a 43-year review. J Pediatr Surg. 1992;27:480–4.CrossRefPubMed
9.
Brown MF, Hebra A, McGeehin K, Ross AJ III. Ovarian masses in children: a review of 91 cases of malignant and benign masses. J Pediatr Surg. 1993;28:930–2.CrossRefPubMed
10.
Trigueros VM, Sereno Colo JA, Villagran UJ. Pure form of primary ovarian choriocarcinoma. Report of a case. Ginecol Obstet Mex. 1995;63:341–5.
11.
Gungor T, Ekin M, Zergeroglu S, Gokmen O. Primary choriocarcinoma of the ovary with coexisting dysgerminoma of the contralateral ovary. J Obstet Gynaecol. 1999;19:325–6.CrossRefPubMed
12.
Inaba H, Kawasaki H, Hamazaki M, Okugawa T, Uchida K, Honzumi M, et al. A case of metastatic ovarian non-gestational choriocarcinoma: successful treatment with conservative type surgery and myeloablative chemotherapy. Pediatr Int. 2000;42:383–5.CrossRefPubMed
13.
Goswami D, Sharma K, Zutshi V, Tempe A, Nigam S. Nongestational pure ovarian choriocarcinoma with contralateral teratoma. Gynecol Oncol. 2001;80:262–6.CrossRefPubMed
14.
Ozdemir I, Demirci F, Yucel O, Demirci E, Alper M. Pure ovarian choriocarcinoma: a difficult diagnosis of an unusual tumor presenting with acute abdomen in a 13-year-old girl. Acta Obstet Gynecol Scand. 2004;83:504–5.CrossRefPubMed
15.
16.
Hayashi S, Abe Y, Tomita S, Nakanishi Y, Miwa S, Nakajima T, et al. Primary non-gestational pure choriocarcinoma arising in the ovary: a case report and literature review. Oncol Lett. 2015;9:2109–11.PubMedPubMedCentral
17.
Xin L, Beier A, Tiede S, Pfiffer T, Kohler C, Favero G. Laparoscopic fertility-preserving treatment of a pure Nongestational Choriocarcinoma of the ovary: case report and review of current literature. J Minim Invasive Gynecol. 2015;22:1095–9.CrossRefPubMed
18.
Wang Q, Guo C, Zou L, Wang Y, Song X, Ma Y, et al. Clinicopathological analysis of non-gestational ovarian choriocarcinoma: report of two cases and review of the literature. Oncol Lett. 2016;11:2599–604.PubMedPubMedCentral
19.
Spingler H, Albert PJ, Schmid M, Müller J. Malignant germ cell tumor in XY gonadal dysgenesis (Swyer syndrome). Geburtshilfe Frauenheilkd. 1990;50:488–90.CrossRefPubMed
20.
Tsujioka H, Hamada H, Miyakawa T, Hachisuga T, Kawarabayashi T. A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis. Gynecol Oncol. 2003;89:540–2.CrossRefPubMed
21.
Koo HL, Choi J, Kim KR, Kim JH. Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. Pathol Int. 2006;56:613–6.CrossRefPubMed
22.
Yamamoto E, Ino K, Yamamoto T, Sumigama S, Nawa A, Nomura S, et al. A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature. Int J Gynecol Cancer. 2007;17:254–8.CrossRefPubMed
23.
Exman P, Takahashi TK, Gattás GF, Cantagalli VD, Anton C, Nalesso F, et al. Primary ovary choriocarcinoma: individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment. Rare Tumors. 2013;5:89–92.CrossRefPubMedPubMedCentral
24.
Lorigan PC, Grierson AJ, Goepel JR, Coleman RE, Goyns MH. Gestational choriocarcinoma of the ovary diagnosed by analysis of tumour DNA. Cancer Lett. 1996;104:27–30.CrossRefPubMed
25.
Gerson RF, Lee EY, Gorman E. Primary extrauterine ovarian choriocarcinoma mistaken for ectopic pregnancy: sonographic imaging findings. AJR am J Roentgenol. 2007;189:280–3.CrossRef
26.
Park SH, Park A, Kim JY, Kwon JH, Koh SB. A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. J Gynecol Oncol. 2009;20:192–4.CrossRefPubMedPubMedCentral
27.
28.
Guvener S, Kazancigil A, Eroz S. Long latent development of trophoblastic disease. Am J Obstet Gynecol. 1972;114:679–84.CrossRef
29.
Lathrop JC, Wachtel TJ, Meissner GF. Uterine choriocarcinoma 14 years following bilateral tubal ligation. Obsfet Gynecol. 1978;51:477–82.CrossRef
30.
Dougherty CM, Cunningham C, Mickai A. Choriocarcinorna with metastasis in a postmenopausal woman. Am J Obstet Gynecol. 1978;132:700–1.CrossRefPubMed
31.
Brown AF, Snodgrass W, Pratt OB. Latent choriocarcinoma. Am J Cancer. 1940;38:564–8.
32.
Witzleben C, Bruninga G. Infantile choriocarcinoma: a characteristic syndrome. J Pediatr. 1963;73:374–8.CrossRef
33.
Jacobs AJ, Newland JR, Green RK. Pure choriocarcinoma of the ovary. Obstet Gynecol Surv. 1982;37:603–9.CrossRefPubMed
34.
Corakci A, Ozeren S, Ozkan S, Gurbuz Y, Ustun H, Yucesoy I. Pure nongestational choriocarcinoma of ovary. Gynecol Obstet. 2005;271:176–7.
35.
Kim PS, Kim SC, Kim JH, Choi YM, Lee HP. Pure choriocarcinoma of ovary. Korean J Obstet Gynecol. 1990;33:1607–11.
36.
Shin YS, You HI, Lim OR, Park SY, Kim YT, Lee KW. A case of primary ovarian choriocarcinoma. Korean J Obstet Gynecol. 1994;37:592–6.
37.
Byeun TS, Byeun C, Chung DY, Park DC, Ahn WS, Lee JW, et al. A case of primary ovarian carcinoma. Korean J Obstet Ol. 1995;38:1713–7.
38.
Balat O, Kutlar I, Ozkur A, Bakir K, Aksoy F, Ugur MG. Primary pure ovarian choriocarcinoma mimicking ectopic pregnancy: a report of fulminant progression. Tumor. 2004;90:136–8.
39.
Bazot M, Cortez A, Sananes S, Buy JN. Imaging of pure primary ovarian choriocarcinoma. AJR am J Roentgenol. 2004;182:1603–4.CrossRefPubMed
40.
Hirabayashi K, Yasuda M, Osamura RY, Hirasawa T, Murakami M. Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with endometriosis. Gynecol Oncol. 2006;102:111–7.CrossRefPubMed
41.
Roghaei MA, Mahzuni P, Rezaei F. A pure nongestational choriocarcinoma of the ovary. J Res Med Sci. 2007;12:269–70.
42.
Mood NI, Samadi N, Rahimi-Moghaddam P, Sarmadi S, Eftekhar Z, Yarandi F. Pure ovarian choriocarcinoma: report of two cases. J Res Med Sci. 2009;14:327–30.PubMedPubMedCentral
43.
Gon S, Majumdar B, Barui G, Karmakar R, Bhattacharya A. Pure primary non-gestational ovarian choriocarcinoma: a diagnostic dilemma. Indian J Pathol Microbiol. 2010;53:178–80.CrossRefPubMed
44.
Haruma T, Ogawa C, Nishida T, Kusumoto T, Nakamura K, Seki N, et al. Pure Choriocarcinoma of the ovary in silver-Russell syndrome. Acta med Okayama. 2015;69:183–8.PubMed
45.
Rao KV, Konar S, Gangadharan J, Vikas V, Sampath S. A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: case report and review of the literature. J Neurosci Rural Pract. 2015;6:578–81.CrossRefPubMedPubMedCentral
Metadata
Title
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature
Authors
Nan Jia
Yan Chen
Xiang Tao
Enzhi Ou
Xin Lu
Weiwei Feng
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2017
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-017-0334-3

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