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Critical Care
Published in: Critical Care 5/2011

01-10-2011 | Commentary

A dynamic view of mHLA-DR expression in management of severe septic patients

Authors: Guillaume Monneret, Alain Lepape, Fabienne Venet

Published in: Critical Care | Issue 5/2011

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Abstract

Increasing evidence suggests that the secondary phase of sepsis (that is, after the first proinflammatory hours) is characterized by the occurrence of a systemic failure of the immune system. In the most immunodepressed patients, therapies could be used to restore normal immune functions. However, biomarkers need to be developed to beforehand specifically identify these patients. Of these biomarkers, diminished monocyte HLA-DR expression has rapidly become the most popular. Herein, novel perspectives regarding monocyte HLA-DR assessed as a dynamic parameter in septic patients will be discussed in the context of a recently published study investigating daily evolution of monocyte HLA-DR with regard to 28 day-mortality after severe sepsis.
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Metadata
Title
A dynamic view of mHLA-DR expression in management of severe septic patients
Authors
Guillaume Monneret
Alain Lepape
Fabienne Venet
Publication date
01-10-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10452

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