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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-01-2014 | Cataract

A dose–response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract

Authors: Le Ma, Zhen-xuan Hao, Ru-ru Liu, Rong-bin Yu, Qiang Shi, Jian-ping Pan

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2014

Abstract

Background

Lutein and zeaxanthin are thought to have beneficial effects on protecting the lens against cataract formation, but findings from epidemiologic studies have been inconsistent. We aimed to conduct a meta-analysis of prospective cohort studies to examine the association between dietary lutein and zeaxanthin intake and risk of age-related cataract (ARC).

Methods

We systematically searched MEDLINE, EMBASE, Web of Science, and Cochrane Library databases up to March 2013. Reference lists from retrieved articles were also reviewed. The adjusted relative risks (RRs) from each study were extracted to calculate a pooled estimate with its 95 % confidence interval (CI). The dose–response relationships were assessed by using generalized least-squares trend estimation.

Results

Six prospective cohort studies were identified involving 4,416 cases and 41,999 participants. For the comparison between the highest and the lowest categories of dietary lutein and zeaxanthin intake, significant inverse association were found for nuclear cataract (RR: 0.75; 95 % CI: 0.65, 0.85), but not for cortical cataract (RR: 0.85; 95 % CI: 0.53, 1.17) and for posterior subcapsular cataract (RR: 0.77; 95 % CI: 0.40, 1.13). Dose–response analysis showed that every 300 μg/d increment in dietary lutein and zeaxanthin intake was associated with a 3 %, 1 %, or 3 % reduction in the risk of nuclear cataract (RR: 0.97; 95 % CI: 0.94, 0.99), cortical cataract (RR: 0.99; 95 % CI: 0.95, 1.02), or posterior subcapsular cataract (RR: 0.97; 95 % CI: 0.93, 1.01) respectively.

Conclusions

Dietary lutein and zeaxanthin intake is associated with a reduced risk of ARC, especially nuclear cataract in a dose–response manner, indicating a beneficial effect of lutein and zeaxanthin in ARC prevention.

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Title: A dose–response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract
Authors: Le Ma
Zhen-xuan Hao
Ru-ru Liu
Rong-bin Yu
Qiang Shi
Jian-ping Pan
Publication date: 01-01-2014
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2014
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-013-2492-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A dose–response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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