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Journal of Assisted Reproduction and Genetics

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01-01-2009 | GENETICS

A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine

Authors: Ganna Livshyts, Svetlana Podlesnaja, Sergey Kravchenko, Iryna Sudoma, Ludmila Livshits

Published in: Journal of Assisted Reproduction and Genetics | Issue 1/2009

Abstract

Purpose

To evaluate the association between phenotype and follicle stimulating hormone receptor (FSHR) genotype in women with ovarian dysfunction and patients with “poor response” to gonadotropin stimulation of ovulation.

Methods

FSHR gene SNPs were analyzed by PCR and RFLP. “Poor responders” (ovarian dysfunction) group and “good responders” group constituted the study group. Normo-ovulatory women who gave birth to naturally conceived children formed control groups: under 35 years of age (control I) and over 35 years of age (control II).

Results

The frequency of Ala307-Ser680/Ala307-Ser680 genotype was significantly more prevalent in the ovarian dysfunction group (26%) compared to the control I (7.7%) (P < 0.001) and a “good responders” group (12.5%) (P < 0.05); and in a “poor responders” group (33.3%) compared to a “good responders” group (P < 0.05), control I (P < 0.001) and control II (17.5%) (P < 0.05).

Conclusions

Our data shows the prevalence of the Ala307-Ser680/ Ala307-Ser680 genotype in the both groups of patients. The finding should have impact on the delineation of stimulation protocols.

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Title: A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine
Authors: Ganna Livshyts
Svetlana Podlesnaja
Sergey Kravchenko
Iryna Sudoma
Ludmila Livshits
Publication date: 01-01-2009
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 1/2009
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-008-9279-1

At a glance: The STEP trials

Springer Medicine

A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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