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European Child & Adolescent Psychiatry
Published in: European Child & Adolescent Psychiatry 10/2017

01-10-2017 | Original Contribution

A developmental approach to dimensional expression of psychopathology in child and adolescent offspring of parents with bipolar disorder

Authors: María Goretti Morón-Nozaleda, Covadonga M. Díaz-Caneja, Elisa Rodríguez-Toscano, Celso Arango, Josefina Castro-Fornieles, Elena de la Serna, Ana Espliego, Vanessa Sanchez-Gistau, Soledad Romero, Immaculada Baeza, Gisela Sugranyes, Carmen Moreno, Dolores Moreno

Published in: European Child & Adolescent Psychiatry | Issue 10/2017

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Abstract

The aim of this is to describe psychopathology, functioning and symptom dimensions accounting for subthreshold manifestations and developmental status in child and adolescent offspring of parents with bipolar disorder (“high-risk offspring”). The study population comprised 90 high-risk offspring (HR-offspring) and 107 offspring of community control parents (CC-offspring). Direct clinical observations and parental and offspring reports based on selected standardized clinical scales were used to assess offspring threshold and subthreshold diagnoses, symptoms and functioning. All outcomes were compared between the whole HR-offspring and CC-offspring samples and then by developmental status. After controlling for potential confounders, HR-offspring showed significantly poorer adjustment for childhood (r = 0.18, p = 0.014) and adolescence (r = 0.21, p = 0.048) than CC-offspring, as well as more emotional problems (r = 0.24, p = 0.001) and higher depression scores (r = 0.16, p = 0.021). As for differences in lifetime categorical diagnoses (threshold and subthreshold) between HR-offspring and CC-offspring, the prevalence of disruptive disorders was higher in pre-pubertal HR-offspring (OR 12.78 [1.45–112.42]), while prevalence of mood disorders was higher in post-pubertal HR-offspring (OR 3.39 [1.14–10.06]). Post-pubertal HR-offspring presented more prodromal (r = 0.40, p = 0.001), negative (r = 0.38, p = 0.002), manic (r = 0.22, p = 0.035) and depressive (r = 0.23, p = 0.015) symptoms than pre-pubertal HR-offspring, as well as more peer relationship problems (r = 0.31, p = 0.004), poorer childhood adjustment (r = 0.22, p = 0.044) and worse current psychosocial functioning (r = 0.27, p = 0.04). Externalizing psychopathology is more prevalent in pre-pubertal HR-offspring, while depressive and prodromal symptoms leading to functional impairment are more prominent in post-pubertal HR-offspring. Developmental approaches and dimensional measures may be useful for identifying children at high risk of developing bipolar disorder and help guide specific preventive strategies.
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Metadata
Title
A developmental approach to dimensional expression of psychopathology in child and adolescent offspring of parents with bipolar disorder
Authors
María Goretti Morón-Nozaleda
Covadonga M. Díaz-Caneja
Elisa Rodríguez-Toscano
Celso Arango
Josefina Castro-Fornieles
Elena de la Serna
Ana Espliego
Vanessa Sanchez-Gistau
Soledad Romero
Immaculada Baeza
Gisela Sugranyes
Carmen Moreno
Dolores Moreno
Publication date
01-10-2017
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry / Issue 10/2017
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-017-0965-3

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