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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 4/2009

01-08-2009 | Case Report

A case report suggesting the occurrence of epithelial–mesenchymal transition in obstructive nephropathy

Authors: Tsutomu Inoue, Hirokazu Okada, Tsuneo Takenaka, Yusuke Watanabe, Hiromichi Suzuki

Published in: Clinical and Experimental Nephrology | Issue 4/2009

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Abstract

Epithelial–mesenchymal transition (EMT) has been well investigated using cultured kidney epithelial cell lines and the mouse obstructive nephropathy model. The role of EMT in the genesis or progression of human renal fibrosis remains controversial. We report a case of obstructive nephropathy that occurred in a pregnant woman. Renal tissue obtained by percutaneous renal biopsy after the delivery showed marked interstitial fibrosis and obstructive tubuli. Immunofluorescence images clearly demonstrated S100A4-positive tubular epithelial cells in these specimens. With regard to human obstructive nephropathy, this is the first report which proves that tubular epithelial cells become positive for the fibroblast-specific marker. EMT is probably a common event not only in mouse but also in human.
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Metadata
Title
A case report suggesting the occurrence of epithelial–mesenchymal transition in obstructive nephropathy
Authors
Tsutomu Inoue
Hirokazu Okada
Tsuneo Takenaka
Yusuke Watanabe
Hiromichi Suzuki
Publication date
01-08-2009
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 4/2009
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-009-0168-4

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