Skip to main content
Top
Published in: Journal of Maxillofacial and Oral Surgery 2/2010

01-06-2010 | Case Report

A case of oral multiple primary cancer including Spindle Cell Carcinoma

Authors: Hideharu Kato, Jouji Nomura, Yoshihiko Matsumura, Shigeaki Yanase, Kaori Miyahara, Rina Matsuura, Toshiro Tagawa

Published in: Journal of Maxillofacial and Oral Surgery | Issue 2/2010

Login to get access

Abstract

Spindle Cell Carcinoma (SPCC) is a relatively rare tumour that is classified as a subtype of squamous cell carcinoma (SCC). Histologically, SPCC is composed of a SCC region and epithelium-derived spindle cells with mesenchymal differentiation. We encountered an interesting case of multiple cancer including SPCC. A histopathologically atypical papillary lesion was found 13 years before our initial examination. Multiple verrucous leukoplakia later developed in the oral mucosa, for which an oral vitamin A derivative (a retinoid) was intermittently administered. Multiple cancer including SPCC subsequently developed in the lower gingiva. We investigated the case histologically and immunohistologically based on the concept of field cancerization.
Literature
1.
go back to reference Barnes L, Eveson JW, Reichart P, Sidransky D (2005) Pathology and genetics of head and neck tumours. IARC Press (International Agency for Research on Cancer), Lyon, p 175 Barnes L, Eveson JW, Reichart P, Sidransky D (2005) Pathology and genetics of head and neck tumours. IARC Press (International Agency for Research on Cancer), Lyon, p 175
2.
go back to reference Thompson LD, Wieneke JA, Miettinen M, Heffner DK (2002) Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol 26(2):153–170CrossRefPubMed Thompson LD, Wieneke JA, Miettinen M, Heffner DK (2002) Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol 26(2):153–170CrossRefPubMed
3.
go back to reference Zidar N, Gale N, Kojc N, Volavsek M, Cardesa A, Alos L, Höfler H, Blechschmidt K, Becker KF (2008) Cadherin-catenin complex and transcription factor snail-1 in spindle cell carcinoma of the head and neck. Virchows Arch 453(3):267–274CrossRefPubMed Zidar N, Gale N, Kojc N, Volavsek M, Cardesa A, Alos L, Höfler H, Blechschmidt K, Becker KF (2008) Cadherin-catenin complex and transcription factor snail-1 in spindle cell carcinoma of the head and neck. Virchows Arch 453(3):267–274CrossRefPubMed
4.
go back to reference Ellis GL, Corio RL (1980) Spindle cell carcinoma of the oral cavity. A clinicopathologic assessment of fifty-nine cases. Oral Surg Oral Med Oral Pathol 50(6):523–533CrossRefPubMed Ellis GL, Corio RL (1980) Spindle cell carcinoma of the oral cavity. A clinicopathologic assessment of fifty-nine cases. Oral Surg Oral Med Oral Pathol 50(6):523–533CrossRefPubMed
5.
go back to reference Su HH, Chu ST, Hou YY, Chang KP, Chen CJ (2006) Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. J Chin Med Assoc 69(10):478–483CrossRefPubMed Su HH, Chu ST, Hou YY, Chang KP, Chen CJ (2006) Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. J Chin Med Assoc 69(10):478–483CrossRefPubMed
6.
go back to reference Fifita SF, Kuyama K, Suzuki A, Tamaki Y, Matsumoto T, Yamamoto H (2006) Case of spindle cell carcinoma of the oral cavity: with special reference to cytopathological features and review of literature. Oral Med Pathol 11(4):127–132CrossRef Fifita SF, Kuyama K, Suzuki A, Tamaki Y, Matsumoto T, Yamamoto H (2006) Case of spindle cell carcinoma of the oral cavity: with special reference to cytopathological features and review of literature. Oral Med Pathol 11(4):127–132CrossRef
7.
go back to reference Leonardi E, Dalri P, Pusiol T, Valdagni R, Piscioli F (1986) Spindle-cell squamous carcinoma of head and neck region: a clinicopathologic and immunohistochemical study of eight cases. ORL J Otorhinolaryngol Relat Spec 48(5):275–281PubMed Leonardi E, Dalri P, Pusiol T, Valdagni R, Piscioli F (1986) Spindle-cell squamous carcinoma of head and neck region: a clinicopathologic and immunohistochemical study of eight cases. ORL J Otorhinolaryngol Relat Spec 48(5):275–281PubMed
8.
go back to reference Zarbo RJ, Crissman JD, Venkat H, Weiss MA (1986) Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immunohistologic and ultrastructural study of 18 biphasic tumours and comparison with seven monophasic spindle-cell tumours. Am J Surg Pathol 10(11):741–753CrossRefPubMed Zarbo RJ, Crissman JD, Venkat H, Weiss MA (1986) Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immunohistologic and ultrastructural study of 18 biphasic tumours and comparison with seven monophasic spindle-cell tumours. Am J Surg Pathol 10(11):741–753CrossRefPubMed
9.
go back to reference Iguchi H, Uyama T, Kanazawa A, Yamamoto H, Amatsu H, Yamane H, Wakasa K (2008) Spindle cell carcinoma as a locally recurrent malignancy after surgery for early lingual squamous cell carcinoma. Acta Otolaryngol 128(11):1273–1276CrossRefPubMed Iguchi H, Uyama T, Kanazawa A, Yamamoto H, Amatsu H, Yamane H, Wakasa K (2008) Spindle cell carcinoma as a locally recurrent malignancy after surgery for early lingual squamous cell carcinoma. Acta Otolaryngol 128(11):1273–1276CrossRefPubMed
10.
go back to reference Hansen LS, Olson JA, Silverman S Jr (1985) Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol 60(3):285–298CrossRefPubMed Hansen LS, Olson JA, Silverman S Jr (1985) Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol 60(3):285–298CrossRefPubMed
11.
go back to reference Cabay RJ, Morton TH Jr, Epstein JB (2007) Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med 36(5):255–261CrossRefPubMed Cabay RJ, Morton TH Jr, Epstein JB (2007) Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med 36(5):255–261CrossRefPubMed
12.
go back to reference Poveda-Roda R, Bagan JV, Jiménez-Soriano Y, Díaz-Fernández JM, Gavaldá-Esteve C (2009) Retinoids and proliferative verrucous leukoplakia (PVL). A preliminary study. Med Oral Patol Oral Cir Bucal 15(1):e3–e9CrossRef Poveda-Roda R, Bagan JV, Jiménez-Soriano Y, Díaz-Fernández JM, Gavaldá-Esteve C (2009) Retinoids and proliferative verrucous leukoplakia (PVL). A preliminary study. Med Oral Patol Oral Cir Bucal 15(1):e3–e9CrossRef
13.
go back to reference López-Jornet P, Alonso FC (2008) Proliferative verrucous leukoplakia and malignant transformation. J Eur Acad Dermatol Venereol 22(9):1138–1139CrossRefPubMed López-Jornet P, Alonso FC (2008) Proliferative verrucous leukoplakia and malignant transformation. J Eur Acad Dermatol Venereol 22(9):1138–1139CrossRefPubMed
14.
go back to reference Bagan JV, Jiménez Y, Murillo J, Poveda R, Díaz JM, Gavaldá C, Margaix M, Scully C, Alberola TM, Torres Puente M, Pérez Alonso M (2008) Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: a preliminary study. Med Oral Patol Oral Cir Bucal 13(2):E110–E113PubMed Bagan JV, Jiménez Y, Murillo J, Poveda R, Díaz JM, Gavaldá C, Margaix M, Scully C, Alberola TM, Torres Puente M, Pérez Alonso M (2008) Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: a preliminary study. Med Oral Patol Oral Cir Bucal 13(2):E110–E113PubMed
15.
go back to reference Morton TH, Cabay RJ, Epstein JB (2007) Proliferative verrucous leukoplakia and its progression to oral carcinoma: report of three cases. J Oral Pathol Med 36(5):315–318CrossRefPubMed Morton TH, Cabay RJ, Epstein JB (2007) Proliferative verrucous leukoplakia and its progression to oral carcinoma: report of three cases. J Oral Pathol Med 36(5):315–318CrossRefPubMed
16.
go back to reference Bishen KA, Sethi A (2009) Proliferative Verrucous Leukoplakia—diagnostic pitfalls and suggestions. Med Oral Patol Oral Cir Bucal 14(6):E263–E264PubMed Bishen KA, Sethi A (2009) Proliferative Verrucous Leukoplakia—diagnostic pitfalls and suggestions. Med Oral Patol Oral Cir Bucal 14(6):E263–E264PubMed
17.
go back to reference Warren S, Gates O (1932) Multiple primary malignant tumours—a survey of the literature and a statistical study. Am J Cancer 16:1358–1414 Warren S, Gates O (1932) Multiple primary malignant tumours—a survey of the literature and a statistical study. Am J Cancer 16:1358–1414
18.
go back to reference U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute (2004) The Seer Program Coding and Staging Manual, vol 1. SEER (Surveillance, Epidemiology and End Results), pp 7–17 U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute (2004) The Seer Program Coding and Staging Manual, vol 1. SEER (Surveillance, Epidemiology and End Results), pp 7–17
19.
go back to reference van Oijen MG, Slootweg PJ (2000) Oral field cancerization: carcinogen-induced independent events or micrometastatic deposits? Cancer Epidemiol Biomarkers Prev 9(3):249–256PubMed van Oijen MG, Slootweg PJ (2000) Oral field cancerization: carcinogen-induced independent events or micrometastatic deposits? Cancer Epidemiol Biomarkers Prev 9(3):249–256PubMed
20.
go back to reference Fisher GJ, Voorhees JJ (1996) Molecular mechanisms of retinoid actions in skin. FASEB J 10(9):1002–1013PubMed Fisher GJ, Voorhees JJ (1996) Molecular mechanisms of retinoid actions in skin. FASEB J 10(9):1002–1013PubMed
Metadata
Title
A case of oral multiple primary cancer including Spindle Cell Carcinoma
Authors
Hideharu Kato
Jouji Nomura
Yoshihiko Matsumura
Shigeaki Yanase
Kaori Miyahara
Rina Matsuura
Toshiro Tagawa
Publication date
01-06-2010
Publisher
Springer-Verlag
Published in
Journal of Maxillofacial and Oral Surgery / Issue 2/2010
Print ISSN: 0972-8279
Electronic ISSN: 0974-942X
DOI
https://doi.org/10.1007/s12663-010-0054-3

Other articles of this Issue 2/2010

Journal of Maxillofacial and Oral Surgery 2/2010 Go to the issue

Guest Editorial

Nurturing the Future

Technical Note

Proboscis Lateralis

Letter to Editor

Letter to Editor