Top

International Journal of Clinical Oncology

Published in:

01-08-2012 | Case Report

A case of myxofibrosarcoma of the maxilla with difficulty in preoperative diagnosis

Authors: Susumu Nakahara, Hirokazu Uemura, Tomoyuki Kurita, Motoyuki Suzuki, Takashi Fujii, Yasuhiko Tomita, Kunitoshi Yoshino

Published in: International Journal of Clinical Oncology | Issue 4/2012

Abstract

Myxofibrosarcoma (MFS) is a very rare fibroblast-derived sarcoma that occurs in the head and neck region. Here, we report the case of a 52-year-old man in whom MFS generated from the maxilla and whose beginning of treatment was considerably delayed because he was initially diagnosed as having a benign inflammatory lesion. Because a definite diagnosis was not obtained via 2 independent biopsies, total maxillectomy was used for both diagnosis and treatment. Histopathological and immunohistochemical analyses suggested that the tumor was a low-grade MFS. Because soft tissue tumors in the head and neck region are rare and a definite diagnosis is relatively difficult, surgical excision is indispensable if malignancy of the tumor is suspected.

Angervall L, Kindblom LG, Merck C (1977) Myxofibrosarcoma. A study of 30 cases. Acta Pathol Microbiol Scand A 85A:127–140PubMed

Merck C, Angervall L, Kindblom LG et al (1983) Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastic-histiocytic origin. A clinicopathologic and prognostic study of 110 cases using multivariate analysis. Acta Pathol Microbiol Immunol Scand Suppl 282:1–40PubMed

Mentzel T, Calonje E, Wadden C et al (1996) Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol 20:391–405PubMedCrossRef

Pomerantz JM, Sanfacon DG, Dougherty TP et al (1982) Myxofibrosarcoma of the maxillary sinus. Del Med J 54:147–152PubMed

Enoz M, Suoglu Y (2007) Myxofibrosarcoma of the maxillary sinus. Internet J Head and Neck Surg 1(1)

Lam PK, Trendell-Smith N, Li JH et al (2002) Myxofibrosarcoma of the sphenoid sinus. J Laryngol Otol 116:464–466

Nishimura G, Sano D, Hanashi M et al (2006) Myxofibrosarcoma of the hypopharynx. Auris Nasus Larynx 33:93–96

Udaka T, Yamamoto H, Shiomori T et al (2006) Myxofibrosarcoma of the neck. J Laryngol Otol 120:872–874

Gugatschka M, Beham A, Stammberger H et al (2010) First case of a myxofibrosarcoma of the vocal folds: case report and review of the literature. J Voice 24:374–376

10.

Li X, Chen X, Shi ZH et al (2010) Primary myxofibrosarcoma of the parotid: case report. BMC Cancer 10:246

11.

Guillou L, Aurias A (2010) Soft tissue sarcomas with complex genomic profiles. Virchows Arch 456:201–217PubMedCrossRef

12.

Dore A, Robertson I, Williamson R et al (2003) Progression of a myxoid pleomorphic fibroma to myxofibrosarcoma. Australas J Dermatol 44:287–290PubMedCrossRef

13.

Huang HY, Lal P, Qin J et al (2004) Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol 35:612–621PubMedCrossRef

Title: A case of myxofibrosarcoma of the maxilla with difficulty in preoperative diagnosis
Authors: Susumu Nakahara
Hirokazu Uemura
Tomoyuki Kurita
Motoyuki Suzuki
Takashi Fujii
Yasuhiko Tomita
Kunitoshi Yoshino
Publication date: 01-08-2012
Publisher: Springer Japan
Published in: International Journal of Clinical Oncology / Issue 4/2012
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-011-0302-7

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2012

Dominant lymph drainage in the facial region: evaluation of lymph nodes of facial melanoma patients

Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture

Tubular nephrotoxicity induced by docetaxel in non-small-cell lung cancer patients

Thinking twice before abandoning first-line chemotherapy in ovarian cancer: report of two cases and literature review. Passing from tri-weekly to weekly regimens

Percent tumor volume predicts biochemical recurrence after radical prostatectomy: multi-institutional data analysis

Fall in plasma ghrelin concentrations after cisplatin-based chemotherapy in esophageal cancer patients

Keynote webinar | Spotlight on antibody–drug conjugates in cancer