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01-09-2014 | Case Report

A case of hypertrophic obstructive cardiomyopathy and acquired von Willebrand syndrome: response to medical therapy

Authors: Masaki Wake, Nobuyuki Takahashi, Hiroyuki Yoshitomi, Kazuaki Tanabe

Published in: Journal of Echocardiography | Issue 3/2014

Abstract

Heyde’s syndrome is the combined occurrence of acquired von Willebrand disease caused by aortic valve stenosis and gastrointestinal bleeding that occurs particularly in elderly patients. The bleeding may be linked to the intravascular shear-induced proteolysis of high-molecular-weight multimers (HMWMs) of von Willebrand factor (vWF). Hypertrophic obstructive cardiomyopathy (HOCM) in the left ventricular outflow tract generates a high shear stress condition that can induce such proteolysis. We report the case of a 70-year-old woman with HOCM who had severe anemia and loss of HMWMs. After reduction of the outflow gradient by medical treatment, vWF normalized, and her anemia alleviated.

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Title: A case of hypertrophic obstructive cardiomyopathy and acquired von Willebrand syndrome: response to medical therapy
Authors: Masaki Wake
Nobuyuki Takahashi
Hiroyuki Yoshitomi
Kazuaki Tanabe
Publication date: 01-09-2014
Publisher: Springer Japan
Published in: Journal of Echocardiography / Issue 3/2014
Print ISSN: 1349-0222
Electronic ISSN: 1880-344X
DOI: https://doi.org/10.1007/s12574-014-0215-3

At a glance: The STEP trials

Springer Medicine

A case of hypertrophic obstructive cardiomyopathy and acquired von Willebrand syndrome: response to medical therapy

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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