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European Journal of Pediatrics
Published in: European Journal of Pediatrics 6/2012

01-06-2012 | Case Report

A 2-month-old infant with vomiting, seizures, and progressive apathy

Authors: Alexander Larsen, Christine Martin, Sascha Meyer, Tilman Rohrer, Panagiotis Papanagiotou, Marjo van der Knaap, Ludwig Gortner

Published in: European Journal of Pediatrics | Issue 6/2012

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Abstract

A 2-month-old infant was admitted to hospital because of recurrent vomiting for 1 week, progressive apathy, and focal seizures. The cranial MRI showed a noticeable result.
Literature
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Alexander WS (1949) Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant. Brain 72:373–381PubMedCrossRef
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Borett D, Becker LE (1985) Alexander´s disease: a disease of astrocytes. Brain 108(Pt 2):367–385CrossRef
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Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE, Messing A (2001) Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet 27:117–120PubMedCrossRef
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Kyllerman M, Rosengren L, Wiklund LM, Hohmberg E (2005) Increased levels of GFAP in the cerebrospinal fluid in three subtypes of genetically confirmed Alexander disease. Neuropediatrics 36(5):319–323PubMedCrossRef
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van der Knaap MS, Naidu S, Breiter SN, Blaser S, Stroink H, Springer S, Begeer JC, van Coster R, Barth PG, Thomas NH, Valk J, Powers JM (2001) Alexander disease: diagnosis with MR imaging. Am J Neuroradiol 22:541–552PubMed
Metadata
Title
A 2-month-old infant with vomiting, seizures, and progressive apathy
Authors
Alexander Larsen
Christine Martin
Sascha Meyer
Tilman Rohrer
Panagiotis Papanagiotou
Marjo van der Knaap
Ludwig Gortner
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 6/2012
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-012-1681-0

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