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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-05-2006 | Original article

^99mTc/¹⁸⁸Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution

Authors: Sandrine Ballot, Nicolas Noiret, François Hindré, Benoît Denizot, Etienne Garin, Holisoa Rajerison, Jean-Pierre Benoit

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2006

Abstract

Purpose

This study focusses on a promising carrier system for imaging and therapeutic purposes using lipid nanocapsules. To assess their potential for clinical use, we labelled nanocapsules with ^99mTc and ¹⁸⁸Re and analysed some kinetic biodistribution parameters after intravenous injection in rats.

Methods

Lipophilic complexes [^99mTc/¹⁸⁸Re(S₃CPh)₂(S₂CPh)] (^99mTc/¹⁸⁸Re-SSS) were encapsulated within the nanoparticles during their manufacture with quantitative yield and satisfactory radiochemical purity. Rats were injected intravenously with 3.7 MBq ^99mTc/¹⁸⁸Re-labelled nanocapsules and sacrificed at 5, 15 and 30 min and 1, 2, 4, 8, 12, 16, 20 and 24 h.

Results

Dynamic scintigraphic acquisitions showed predominant hepatic uptake, and ex vivo counting indicated a long circulation time of labelled nanocapsules, with a half-life of 21±1 min for ^99mTc and 22±2 min for ¹⁸⁸Re. Very weak urinary elimination was observed, indicating good stability of ^99mTc and ¹⁸⁸Re labelling.

Conclusion

^99mTc/¹⁸⁸Re-SSS nanocapsules can be obtained with high yield and satisfactory radiochemical purity. The biodistributions of ^99mTc/¹⁸⁸Re-labelled nanocapsules are close to those of classical PEG-coated particles and show good stability of ¹⁸⁸Re/^99mTc-SSS labelling.

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Title: 99mTc/188Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution
Authors: Sandrine Ballot
Nicolas Noiret
François Hindré
Benoît Denizot
Etienne Garin
Holisoa Rajerison
Jean-Pierre Benoit
Publication date: 01-05-2006
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2006
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-005-0007-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

^99mTc/¹⁸⁸Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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