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01-01-2004 | Chest

³He-MRI in follow-up of lung transplant recipients

Authors: Klaus Kurt Gast, Julia Zaporozhan, Sebastian Ley, Alexander Biedermann, Frank Knitz, Balthasar Eberle, Joerg Schmiedeskamp, Claus-Peter Heussel, Eckhard Mayer, Wolfgang Günter Schreiber, Manfred Thelen, Hans-Ulrich Kauczor

Published in: European Radiology | Issue 1/2004

Abstract

The aim of this study was to evaluate the possible contribution of ³He-MRI to detect obliterative bronchiolitis (OB) in the follow-up of lung transplant recipients. Nine single- and double-lung transplanted patients were studied by an initial and a follow-up ³He-MRI study. Images were evaluated subjectively by estimation of ventilation defect area and quantitatively by individually adapted threshold segmentation and subsequent calculation of ventilated lung volume. Bronchiolitis obliterans syndrome (BOS) was diagnosed using pulmonary function tests. At ³He-MRI, OB was suspected if ventilated lung volume had decreased by 10% or more at the follow-up MRI study compared with the initial study. General accordance between pulmonary function testing and ³He-MRI was good, although subjective evaluation of ³He-MRI underestimated improvement in ventilation as obtained by pulmonary function tests. The ³He-MRI indicated OB in 6 cases. According to pulmonary function tests, BOS was diagnosed in 5 cases. All diagnoses of BOS were also detected by ³He-MRI. In 2 of these 5 cases, ³He-MRI indicated OB earlier than pulmonary function tests. The results support the hypothesis that ³He-MRI may be sensitive for early detection of OB and emphasize the need for larger prospective follow-up studies.

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Title: 3He-MRI in follow-up of lung transplant recipients
Authors: Klaus Kurt Gast
Julia Zaporozhan
Sebastian Ley
Alexander Biedermann
Frank Knitz
Balthasar Eberle
Joerg Schmiedeskamp
Claus-Peter Heussel
Eckhard Mayer
Wolfgang Günter Schreiber
Manfred Thelen
Hans-Ulrich Kauczor
Publication date: 01-01-2004
Publisher: Springer-Verlag
Published in: European Radiology / Issue 1/2004
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-003-2092-4

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³He-MRI in follow-up of lung transplant recipients

Abstract

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Abstract

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