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Radiation Oncology

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Open Access 01-12-2010 | Research

3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma

Authors: Yu-Feng Ren, Yuan-Hong Gao, Xin-Ping Cao, Wei-Jun Ye, Bin S Teh

Published in: Radiation Oncology | Issue 1/2010

Abstract

Background

To compare the results of external beam radiotherapy in combination with 3D- computed tomography (CT)-implanted interstitial high dose rate brachytherapy (ERT/3D-HDR-BT) versus conventional external beam radiotherapy (ERT) for the treatment of stage T2b nasopharyngeal carcinoma (NPC).

Methods

Forty NPC patients diagnosed with stage T2b NPC were treated with ERT/3D-HDR-BT under local anesthesia. These patients received a mean dose of 60 Gy, followed by 12-20 Gy administered by 3D-HDR-BT. Another 101 patients diagnosed with non-metastatic T2b NPC received a mean dose of 68 Gy by ERT alone during the same period.

Results

Patients treated with ERT/3D-HDR-BT versus ERT alone exhibited an improvement in their 5-y local failure-free survival rate (97.5% vs. 80.2%, P = 0.012) and disease-free survival rate (92.5% vs. 73.3%, P = 0.014). Using multivariate analysis, administration of 3D-HDR-BT was found to be favorable for local control (P = 0.046) and was statistically significant for disease-free survival (P = 0.021). The incidence rate of acute and chronic complications between the two groups was also compared.

Conclusions

It is possible that the treatment modality enhances local control due to improved conformal dose distributions and the escalated radiation dose applied.

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Title: 3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma
Authors: Yu-Feng Ren
Yuan-Hong Gao
Xin-Ping Cao
Wei-Jun Ye
Bin S Teh
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2010
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-5-113

Keynote webinar | Spotlight on medication adherence

Springer Medicine

3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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