Top

Published in:

01-08-2016 | Images that Teach

[18F]-NaF PET/CT imaging in cardiac amyloidosis

Authors: Axel Van Der Gucht, MD, Arnault Galat, MD, Jean Rosso, MD, Aziz Guellich, PhD, Jérôme Garot, MD, PhD, Diane Bodez, MD, Violaine Plante-Bordeneuve, MD, PhD, Luc Hittinger, MD, PhD, Jean-Luc Dubois-Randé, MD, PhD, Eva Evangelista, MD, Myriam Sasanelli, MD, Julia Chalaye, MD, Michel Meignan, MD, PhD, Emmanuel Itti, MD, PhD, Thibaud Damy, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 4/2016

Abstract

Cardiac amyloidosis (CA) is recognized as a common cause of restrictive cardiomyopathy and heart failure due to the deposition of insoluble proteins in the myocardial interstitium. We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis. We report cases of a 73-year-old man and a 75-year-old woman followed in our center for congestive heart failure with marked alteration of the left ventricular ejection fraction due to familial transthyretin Val122Ile cardiac amyloidosis and light-chain cardiac amyloidosis, respectively, confirmed on endomyocardial biopsy.

Galat A, Rosso J, Guellich A, Van Der Gucht A, Rappeneau S, Bodez D, et al. Uselfulness of 99mTc HMDP-scintigraphy for the etiologic diagnosis and prognosis of cardiac amyloidosis. Amyloid. 2015 (in press).

Glaudemans AWJM, van Rheenen RWJ, van den Berg MP, Noordzij W, Koole M, Blokzijl H, et al. Bone scintigraphy with (99m)technetium-hydroxymethylene diphosphonate allows early diagnosis of cardiac involvement in patients with transthyretin-derived systemic amyloidosis. Amyloid. 2014;21:35–44.CrossRefPubMed

Worsley DF, Lentle BC. Uptake of technetium-99m MDP in primary amyloidosis with a review of the mechanisms of soft tissue localization of bone seeking radiopharmaceuticals. J Nucl Med. 1993;34:1612–5.PubMed

Kulhanek J, Movahed A. Uptake of technetium 99m HDP in cardiac amyloidosis. Int J Cardiovasc Imaging. 2003;19:225–7.CrossRefPubMed

Rapezzi C, Quarta CC, Guidalotti PL, Pettinato C, Fanti S, Leone O, et al. Role of (99m)Tc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis. JACC Cardiovasc Imaging. 2011;4:659–70.CrossRefPubMed

Title: [18F]-NaF PET/CT imaging in cardiac amyloidosis
Authors: Axel Van Der Gucht, MD
Arnault Galat, MD
Jean Rosso, MD
Aziz Guellich, PhD
Jérôme Garot, MD, PhD
Diane Bodez, MD
Violaine Plante-Bordeneuve, MD, PhD
Luc Hittinger, MD, PhD
Jean-Luc Dubois-Randé, MD, PhD
Eva Evangelista, MD
Myriam Sasanelli, MD
Julia Chalaye, MD
Michel Meignan, MD, PhD
Emmanuel Itti, MD, PhD
Thibaud Damy, MD, PhD
Publication date: 01-08-2016
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 4/2016
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-015-0287-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

[18F]-NaF PET/CT imaging in cardiac amyloidosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2016

Accurate analysis and visualization of cardiac 11C-PIB uptake in amyloidosis with semiautomatic software

The characterization and prognostic significance of right ventricular glucose metabolism in non-ischemic dilated cardiomyopathy

Comparative analysis of cadmium-zincum-telluride cameras dedicated to myocardial perfusion SPECT: A phantom study

Transplant allograft vasculopathy: Role of multimodality imaging in surveillance and diagnosis

Which SPECT for today, which SPECT for tomorrow?

So We May Not Forget!