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01-12-2016 | Correspondence

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration

Authors: Keith A. Josephs, Jennifer L. Whitwell, Pawel Tacik, Joseph R. Duffy, Matthew L. Senjem, Nirubol Tosakulwong, Clifford R. Jack, Val Lowe, Dennis W. Dickson, Melissa E. Murray

Published in: Acta Neuropathologica | Issue 6/2016

Excerpt

Corticobasal degeneration (CBD) is a neurodegenerative disease characterized by the deposition of abnormally hyperphosphorylated 4-repeat (4R) tau in the brain [3]. Recent advances in molecular neuroimaging include the production of positron emission tomography (PET) ligands that bind to abnormal tau in the brain. One such ligand, [18F]AV-1451, has been shown to bind to abnormal 3R + 4R tau in diseases such as Alzheimer’s disease [2]. In addition, one case report found an association between antemortem [18F]AV-1451 and tau burden in an autopsied case with a mutation in the microtubule-associated protein tau gene with 3R + 4R tau [9]. Autoradiographic studies however have found very little, if any, binding in diseases characterized by 4R-tau including CBD [6‐8], and no PET-autopsy studies have been published for a 4R-tau disease. …

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Title: [18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration
Authors: Keith A. Josephs
Jennifer L. Whitwell
Pawel Tacik
Joseph R. Duffy
Matthew L. Senjem
Nirubol Tosakulwong
Clifford R. Jack
Val Lowe
Dennis W. Dickson
Melissa E. Murray
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 6/2016
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-016-1618-1

At a glance: The STEP trials

Springer Medicine

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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