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Acta Neuropathologica
Published in: Acta Neuropathologica 2/2005

01-08-2005 | Letter to the Editor

14-3-3 proteins in Lewy body-like hyaline inclusions in a patient with familial amyotrophic lateral sclerosis with a two-base pair deletion in the Cu/Zn superoxide dismutase (SOD1) gene

Authors: Yasuhiro Kawamoto, Ichiro Akiguchi, Harutoshi Fujimura, Yoshitomo Shirakashi, Yasuyuki Honjo, Saburo Sakoda

Published in: Acta Neuropathologica | Issue 2/2005

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Excerpt

14-3-3 proteins are molecular chaperones that regulate various types of signal transduction pathways through phosphorylation-dependent protein-protein interactions [1]. Recently, we demonstrated the immunohistochemical localization of 14-3-3 proteins in Lewy body-like hyaline inclusions (LBHIs) in patients with sporadic amyotrophic lateral sclerosis (SALS) [6]. In the present study, we performed immunohistochemical studies on 14-3-3 proteins in formalin-fixed, paraffin-embedded sections from a patient with familial ALS (FALS), with a two-base pair deletion in the Cu/Zn superoxide dismutase (SOD1) gene, using anti-peptide antibodies that were already confirmed to be specific for human 14-3-3 proteins [4, 5]. …
Literature
1.
Fu H, Subramanian RR, Masters SC (2000) 14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol 40:617–647CrossRefPubMed
2.
Kadekawa J, Fujimura H, Ogawa Y, Hattori N, Kaido M, Nishimura T, Yoshikawa H, Shirahata N, Sakoda S, Yanagihara T (1997) A clinicopathological study of a patient with familial amyotrophic lateral sclerosis associated with a two base pair deletion in the copper/zinc superoxide dismutase (SOD1) gene. Acta Neuropathol 94:617–622CrossRefPubMed
3.
Kato S, Saito M, Hirano A, Ohama E (1999) Recent advances in research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 gene mutations: neuronal Lewy body-like hyaline inclusions and astrocytic hyaline inclusions. Histol Histopathol 14:973–989PubMed
4.
Kawamoto Y, Akiguchi I, Nakamura S, Honjyo Y, Shibasaki H, Budka H (2002) 14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains. J Neuropathol Exp Neurol 61:245–253PubMed
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Kawamoto Y, Akiguchi I, Nakamura S, Budka H (2002) Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy. Ann Neurol 52:722–731CrossRefPubMed
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Kawamoto Y, Akiguchi I, Nakamura S, Budka H (2004) 14-3-3 proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis. Acta Neuropathol 108:531–537CrossRefPubMed
Metadata
Title
14-3-3 proteins in Lewy body-like hyaline inclusions in a patient with familial amyotrophic lateral sclerosis with a two-base pair deletion in the Cu/Zn superoxide dismutase (SOD1) gene
Authors
Yasuhiro Kawamoto
Ichiro Akiguchi
Harutoshi Fujimura
Yoshitomo Shirakashi
Yasuyuki Honjo
Saburo Sakoda
Publication date
01-08-2005
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 2/2005
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-005-1039-z

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