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Published in: International Urogynecology Journal 6/2008

01-06-2008 | Case Report

1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence

Authors: L. K. Carr, D. Steele, S. Steele, D. Wagner, R. Pruchnic, R. Jankowski, J. Erickson, J. Huard, M. B. Chancellor

Published in: International Urogynecology Journal | Issue 6/2008

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Abstract

We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections. Mean and median follow-up in this group was 16.5 and 17 months (range 3–24 months). Improvement in SUI was seen in five of eight women, with one achieving total continence. Onset of improvement was between 3 and 8 months after injection. Cure or improvement continued at a median of 10 months. No serious adverse events were reported.
Literature
2.
go back to reference Kiilholma P, Chancellor MB, Makinen J, Hirsch IH, Klemi PJ (1993) Complications of Teflon injections for stress urinary incontinence. Neurourol Urodyn 12:131–137PubMedCrossRef Kiilholma P, Chancellor MB, Makinen J, Hirsch IH, Klemi PJ (1993) Complications of Teflon injections for stress urinary incontinence. Neurourol Urodyn 12:131–137PubMedCrossRef
3.
go back to reference Huard J, Yokoyama T, Pruchnic R, Qu Z, Li Y, Lee JY, Somogyi GT, de Groat WT, Chancellor MB (2002) Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction. Gene Ther 9:1617–1626PubMedCrossRef Huard J, Yokoyama T, Pruchnic R, Qu Z, Li Y, Lee JY, Somogyi GT, de Groat WT, Chancellor MB (2002) Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction. Gene Ther 9:1617–1626PubMedCrossRef
4.
go back to reference Rodriguez LV, Alfonso Z, Zhang R, Leung J, Wu B, Ignarro LJ (2006) Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. PNAS 103:12167–12172PubMedCrossRef Rodriguez LV, Alfonso Z, Zhang R, Leung J, Wu B, Ignarro LJ (2006) Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. PNAS 103:12167–12172PubMedCrossRef
5.
go back to reference Strasser H, Marksteiner R, Margreiter E (2006) Transurethral ultrasound guided stem cell therapy of urinary incontinence. J Urol 175:291–292CrossRef Strasser H, Marksteiner R, Margreiter E (2006) Transurethral ultrasound guided stem cell therapy of urinary incontinence. J Urol 175:291–292CrossRef
6.
go back to reference Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tubita K, Keller BB, Cummins JH, Huard J (2005) Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Ther 12:1130–1141PubMedCrossRef Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tubita K, Keller BB, Cummins JH, Huard J (2005) Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Ther 12:1130–1141PubMedCrossRef
7.
go back to reference Lee JY, Qu-Petersen Z, Cao B, Kimura S, Jankowski R, Cummins J, Usas A, Gates G, Robbins P, Wernig A, Huard J (2000) Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 150:1085–1100PubMedCrossRef Lee JY, Qu-Petersen Z, Cao B, Kimura S, Jankowski R, Cummins J, Usas A, Gates G, Robbins P, Wernig A, Huard J (2000) Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 150:1085–1100PubMedCrossRef
8.
go back to reference Qu-Petersen Z, Deasy B, Jankowski R, Ikezawa M, Cummins J, Pruchnic R, Mytinger J, Cao B, Gates C, Wernig A, Huard J (2002) Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J Cell Biol 157:851–864PubMedCrossRef Qu-Petersen Z, Deasy B, Jankowski R, Ikezawa M, Cummins J, Pruchnic R, Mytinger J, Cao B, Gates C, Wernig A, Huard J (2002) Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J Cell Biol 157:851–864PubMedCrossRef
9.
go back to reference Kwon D, Kim Y, Pruchnic R, Jankowski R, Isiene I, de Miguel F, Huard J, Chancellor MB (2006) Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. Urology 68:449–454PubMedCrossRef Kwon D, Kim Y, Pruchnic R, Jankowski R, Isiene I, de Miguel F, Huard J, Chancellor MB (2006) Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. Urology 68:449–454PubMedCrossRef
Metadata
Title
1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence
Authors
L. K. Carr
D. Steele
S. Steele
D. Wagner
R. Pruchnic
R. Jankowski
J. Erickson
J. Huard
M. B. Chancellor
Publication date
01-06-2008
Publisher
Springer-Verlag
Published in
International Urogynecology Journal / Issue 6/2008
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-007-0553-z

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