Published in:
01-07-2008 | Contributions from International Congress
1.8 A Functional LDL Receptor-Related Protein 6 Gene Variant is an Independent Risk Factor For Early Carotid Artery Atherosclerosis in Hypertensive Patients
Authors:
R. Sarzani, F. Salvi, M. Bordicchia, F. Guerra, I. Battistoni, L. Roberti, M. Fortunati, P. Dessì-Fulgheri, A. Rappelli
Published in:
High Blood Pressure & Cardiovascular Prevention
|
Issue 3/2008
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Excerpt
Introduction. Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) is a co-receptor in the canonical Wnt/beta-catenin signalling pathway. Common (I1062V) and rare (R61 1C) variants display reduced activation Wnt/beta-catenin signalling. The rare gene variant causes hypertension, metabolic abnormalities, and early coronary artery disease. …