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Published in: High Blood Pressure & Cardiovascular Prevention 3/2008

01-07-2008 | Contributions from International Congress

1.8 A Functional LDL Receptor-Related Protein 6 Gene Variant is an Independent Risk Factor For Early Carotid Artery Atherosclerosis in Hypertensive Patients

Authors: R. Sarzani, F. Salvi, M. Bordicchia, F. Guerra, I. Battistoni, L. Roberti, M. Fortunati, P. Dessì-Fulgheri, A. Rappelli

Published in: High Blood Pressure & Cardiovascular Prevention | Issue 3/2008

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Excerpt

Introduction. Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) is a co-receptor in the canonical Wnt/beta-catenin signalling pathway. Common (I1062V) and rare (R61 1C) variants display reduced activation Wnt/beta-catenin signalling. The rare gene variant causes hypertension, metabolic abnormalities, and early coronary artery disease. …
Metadata
Title
1.8 A Functional LDL Receptor-Related Protein 6 Gene Variant is an Independent Risk Factor For Early Carotid Artery Atherosclerosis in Hypertensive Patients
Authors
R. Sarzani
F. Salvi
M. Bordicchia
F. Guerra
I. Battistoni
L. Roberti
M. Fortunati
P. Dessì-Fulgheri
A. Rappelli
Publication date
01-07-2008
Publisher
Springer International Publishing
Published in
High Blood Pressure & Cardiovascular Prevention / Issue 3/2008
Print ISSN: 1120-9879
Electronic ISSN: 1179-1985
DOI
https://doi.org/10.1007/BF03263589

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