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01-03-2015 | Original Article

β-Cryptoxanthin ameliorates the reproductive toxicity of chlorpyrifos in male rabbit

Authors: Omid Mavedati, Esmaeil Bandariyan, Siyavash Aminashayeri, Taher Mamash Sergez, Babak Abas Beigi

Published in: Comparative Clinical Pathology | Issue 2/2015

Abstract

Exposure to pesticides became a routine and increasingly risky phenomenon. The harmful effects of occupational exposure to pesticides on health are irreversible in some cases. Chlorpyrifos is a broad spectrum organophosphorus insecticide that is widely used in agriculture, horticulture, and in domestic and urban pest control. Chlorpyrifos alters reproductive function by altering the activity of the pituitary-thyroid and pituitary-adrenal axes giving credence to its endocrine disrupting effect. β-Cryptoxanthin is a provitamin A carotenoid. β-cryptoxanthin is an antioxidant and may help prevent free radical damage to biomolecules. In the present study, we investigated the role of β-Cryptoxanthin in alleviating the negative effects of chlorpyrifos on reproductive characteristics in rabbits. Thirty mature male rabbits were randomly divided into five equal groups of six rabbits in each. Group 1 served as control. Group 2 was given β-Cryptoxanthin. Group 3 was orally given chlorpyrifos. Group 4 was given the combination of chlorpyrifos and β-Cryptoxanthin (5 mg/kg). Group 5 was given the combination of chlorpyrifos and β-Cryptoxanthin (10 mg/kg). The results showed that body weight, relative weights of testes and epididymis, feed intake, and plasma testosterone concentration were decreased significantly (P < 0.05) in rabbits treated with chlorpyrifos as compared to control or β-Cryptoxanthin-treated groups. Treatment with chlorpyrifos decreased (P < 0.05) semen ejaculate volume, packed sperm volume, sperm concentration, total sperm output, sperm motility, total motile sperm per ejaculate, total functional sperm fraction, normal sperm, and initial fructose as compared to control and β-Cryptoxanthin-treated rabbit groups. From the present results, it can be concluded that coadministration of β-Cryptoxanthin to chlorpyrifos-treated animals ameliorated the induced sperm quality damage and significantly improved the sperm parameters.

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Title: β-Cryptoxanthin ameliorates the reproductive toxicity of chlorpyrifos in male rabbit
Authors: Omid Mavedati
Esmaeil Bandariyan
Siyavash Aminashayeri
Taher Mamash Sergez
Babak Abas Beigi
Publication date: 01-03-2015
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 2/2015
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-014-1917-7

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β-Cryptoxanthin ameliorates the reproductive toxicity of chlorpyrifos in male rabbit

Abstract

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