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Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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Neurology
Open Access Cerebral Hemorrhage Review

BP management in intracerebral hemorrhage

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Hypertension is common in ICH, but inconsistent trial results have led to weak recommendations about acute blood pressure therapy. What target, timing, intensity, and agents should be used?

Editor's Choice

Polyvascular disease: a serious situation

Free for a limited time Arterial Diseases Review

Polyvascular disease (atherosclerosis in multiple vascular beds) has a high prevalence and elevated risk of mortality. Early identification and treatment are crucial to reduce disease progression. 

Insomnia, short sleep, and weight

Open Access Obesity Review

Insomnia and short sleep have been linked with weight gain and obesity, but does the evidence support this association? And what impact might behavioral and pharmacological treatments for sleep have on weight?  

Important milestone in symptomatic treatment of MND

29-05-2024 Disease of Central Nervous System News

Acceptance and commitment therapy combined with usual care enhances the quality of life for individuals with motor neuron disease.

Neonatal meningitis: new and old lessons

Open Access Meningitis in Childhood Case Study

A premature infant with extensive central nervous system injury from recurrent E. coli infection, requiring non-traditional methods to identify and clear the infection.

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Latest News

Decompressive craniectomy may improve intracerebral hemorrhage outcomes

31-05-2024 Hemorrhagic Stroke News

Important milestone in symptomatic treatment of MND

29-05-2024 Disease of Central Nervous System News

Potential biomarker for predicting apheresis response in MS

24-05-2024 Multiple Sclerosis News

Tau burden differs between Down syndrome and hereditary AD

22-05-2024 Alzheimer's Disease News

Potential neuroprotection in cardiac arrest-induced coma

21-05-2024 Coma News

Reducing relapse risk in Sydenham chorea

14-05-2024 Post-Infection Chorea News
Webinar | 02-05-2024 | 17:30 (CEST)

Keynote webinar | Spotlight on sleep in brain health

Watch now

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine

Case Studies

Neonatal meningitis: new and old lessons

Open Access Meningitis in Childhood Case Study

A premature infant with extensive central nervous system injury from recurrent E. coli infection, requiring non-traditional methods to identify and clear the infection.

Stenting for subclavian steal phenomenon to restore cerebral perfusion

Open Access Carotid Endarterectomy Case Study

Subclavian artery stenting is safe and may be helpful in patients with cerebral perfusion deficiency caused by intractable acute carotid occlusion coexisting with subclavian steal.

Hypotensive twilight zone in Parkinson’s disease

Free for a limited time Parkinson's Disease Case Study

Almost daily episodes of reduced responsiveness lasting up to an hour, with the patient slumped back in a chair but staying upright, indicated an under-recognised presentation of orthostatic hypotension.

Current Reviews

Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis Review

Despite considerable research efforts, it is still not clear which mechanisms underlie neuronal cell death in neurodegenerative diseases. During the last 20 years, multiple pathways have been identified that can execute regulated cell death (RCD).

The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders

Open Access Central Nervous System Trauma Review

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (Aβ), hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed pathology, characterizes the most common neurodegenerative …

Endothelial cells and macrophages as allies in the healthy and diseased brain

Open Access Multiple Sclerosis Review

Diseases of the central nervous system (CNS) are often associated with vascular disturbances or inflammation and frequently both. Consequently, endothelial cells and macrophages are key cellular players that mediate pathology in many CNS diseases.

Complement and MHC patterns can provide the diagnostic framework for inflammatory neuromuscular diseases

Open Access Dermatomyositis Review

Histopathological analysis stands as the gold standard for the identification and differentiation of inflammatory neuromuscular diseases. These disorders continue to constitute a diagnostic challenge due to their clinical heterogeneity, rarity and …
Alzheimer's Disease Independent Medical Education

Advances in Alzheimer's

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Alzheimer's research and care is changing rapidly. Keep up with the latest developments from key international conferences, together with expert insights on how to integrate these advances into practice.

This content is intended for healthcare professionals outside of the UK.

Supported by: Lilly

Developed by: Springer Healthcare IME

CME & eLearning

News | Vodcasts | Podcasts (Link opens in a new window)

Alzheimer's Disease

1.5 AMA PRA Category 1 Credit(s)™

Emerging biomarkers and disease-modifying therapies for Alzheimer’s disease promise significant changes in how the condition is diagnosed and managed.

Guide yourself through this transition with our education program, led by world renowned experts and covering the biggest international conferences.

This content is intended for healthcare professionals outside of the UK.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME

Webinar (Link opens in a new window)

Amyloidosis

Interact with experts from established amyloidosis centers who can offer you specialized guidance to support your mission to set up a local center. Network with other HCPs in your locality to discuss region-specific challenges in establishing amyloidosis centers. 

Supported by:
  • AstraZeneca and Alexion
Developed by: Springer Healthcare IME

Webcast | eLearning | Infographic (Link opens in a new window)

Alzheimer's Disease

PET biomarkers are fast becoming critical in the new era of disease modification for Alzheimer’s disease. Techniques around amyloid and tau require the expertise of nuclear medicine and radiology physicians to investigate and interpret PET scans in clinical settings. This program examines current and emerging biomarkers and assists in identifying patterns from different PET tracers in an interactive perceptual learning environment.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME
Alzheimer's Disease Independent Medical Education

Neuroimaging for Alzheimer’s disease: eLearning (Link opens in a new window)

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Neuroimaging plays an increasingly critical role in clinical practice. PET Pearls is an interactive activity designed to improve your confidence and accuracy when interpreting imaging for early signs of cognitive impairment.

Supported by: Lilly

Developed by: Springer Healthcare IME

Neurology journals

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Further Reading

The influence of APOEε4 on the pTau interactome in sporadic Alzheimer’s disease

Open Access Alzheimer's Disease Original Paper

APOEε4 is the major genetic risk factor for sporadic Alzheimer’s disease (AD). Although APOEε4 is known to promote Aβ pathology, recent data also support an effect of APOE polymorphism on phosphorylated Tau (pTau) pathology. To elucidate these …

Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions

Open Access Multiple Sclerosis Original Paper

Multiple sclerosis (MS) is a heterogeneous neurological disorder with regards to clinical presentation and pathophysiology. Here, we investigated the heterogeneity of MS by performing an exploratory factor analysis on quantitative and qualitative …

CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease

Open Access Alzheimer's Disease Original Paper

Post-mortem staging of Alzheimer’s disease (AD) neurofibrillary pathology is commonly performed by immunohistochemistry using AT8 antibody for phosphorylated tau (p-tau) at positions 202/205. Thus, quantification of p-tau205 and p-tau202 in …

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

Open Access Alzheimer's Disease Original Paper

Synapse loss correlates with cognitive decline in Alzheimer’s disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of understanding of how Aβ leads to synapse …

Related topics

Open Access Cerebral Hemorrhage Review

BP management in intracerebral hemorrhage

Hypertension is common in ICH, but inconsistent trial results have led to weak recommendations about acute blood pressure therapy. What target, timing, intensity, and agents should be used?

Read more

Polyvascular disease: a serious situation

Free for a limited time Arterial Diseases Review

Stenting for subclavian steal phenomenon to restore cerebral perfusion

Open Access Carotid Endarterectomy Case Study

Collateral circulation: the future of ischemic stroke therapy?

Free for a limited time Ischemic Stroke Review

Antipsychotic use in dementia has broad adverse outcomes

10-05-2024 Dementia News

How neuroimmunology affects the heart

Open Access Circulatory Disease Review
Open Access Dementia Review

Differentiating prodromal dementia: DLB vs AD

Overlapping clinical phenotypes make diagnosis challenging in patients with mild cognitive impairment. What clinical and biological features can help characterize dementia with Lewy bodies versus Alzheimer's disease?

Read more

Biomarkers for dementia with Lewy bodies

Dementia Review

Antipsychotic use in dementia has broad adverse outcomes

10-05-2024 Dementia News

Delirium associated with an increased risk for dementia

02-05-2024 Dementia News

Healthy blood, healthy brain

Dementia Review

Post-traumatic epilepsy increases risk for dementia later in life

20-03-2024 Epilepsy News
08-04-2024 Epilepsy News

A link between antiseizure medication use in pregnancy and autism?

Children born to women with epilepsy who take topiramate when pregnant are not at increased risk for autism spectrum disorders, whereas there is an increased risk with valproate.

Read more

Post-traumatic epilepsy increases risk for dementia later in life

20-03-2024 Epilepsy News

Antiepileptic strategies for patients with brain tumors

Open Access Central Nervous System Cancer Review

Rescue therapies for seizure clusters

Open Access Epilepsy Review

Is it migraine or epilepsy?

Open Access Migraine Review

Cardiovascular risk increased in epilepsy

30-01-2024 Epilepsy News
Open Access Meningitis in Childhood Case Study

Neonatal meningitis: new and old lessons

A premature infant with extensive central nervous system injury from recurrent E. coli infection, requiring non-traditional methods to identify and clear the infection.

Read more

Multiorgan involvement of fungal infection after near drowning

Open Access Neurological Involvement in Infectious Disease Case Study

How neuroimmunology affects the heart

Open Access Circulatory Disease Review

Bacterial ventriculitis in a patient with severe periodontitis

Open Access Inflammatory Brain Disease Case Study

Pediatric relapsing autoimmune encephalitis

Open Access Autoimmune Encephalitis Review

Using combined PET-MRI to diagnose autoimmune limbic encephalitis

Open Access Autoimmune Encephalitis Case Study
Open Access Meningitis in Childhood Case Study

Neonatal meningitis: new and old lessons

A premature infant with extensive central nervous system injury from recurrent E. coli infection, requiring non-traditional methods to identify and clear the infection.

Read more

Low-grade glioma in adolescents and young adults

Free for a limited time Glioma Review

CHANTER syndrome from fentanyl exposure in a young child

Open Access Cerebral Edema Case Study

Multiorgan involvement of fungal infection after near drowning

Open Access Neurological Involvement in Infectious Disease Case Study

Improving drug delivery in glioblastoma

Open Access Glioblastoma Review

Bacterial ventriculitis in a patient with severe periodontitis

Open Access Inflammatory Brain Disease Case Study
Type 2 Diabetes Review

The gut microbiota, gut–brain axis, and type 2 diabetes

The gut microbiota and host communicate bidirectionally along the gut–brain axis to regulate glucose homeostasis, and evidence supports a role for dysbiosis of the gut microbiota in the development of type 2 diabetes.

Read more

Orthopnea secondary to brachial plexitis with bilateral diaphragmatic paralysis

Open Access Neuralgic Shoulder Amyotrophy Case Study

Vasculitic neuropathies

Peripheral Nervous System Disease Review

Chronic cough as a genetic neurological disorder? Insights from CANVAS

Open Access Cough Review

Diabetic microvascular disease beyond the retina, kidney, and peripheral nerves

Open Access Diabetes-associated Diseases Review

Neurotoxicity of cancer immunotherapies

Cancer Immunotherapy Review
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