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Basic Principles of Statistical Inference

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Topics in Biostatistics

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 404))

Abstract

In this chapter, we discuss the fundamental principles behind two of the most frequently used statistical inference procedures: confidence interval estimation and hypothesis testing. both procedures are constructed on the sampling distributions that we have learned in previous chapters. To better understand these inference procedures, we focus on the logic of statistical decision making and the role that experimental data play in the decision process. Numerical examples are used to illustrate the implementation of the discussed procedures. This chapter also introduces some of the most important concepts associated with confidence interval estimation and hypothesis testing, including P values, significance level, power, sample size, and two types of errors. We conclude the chapter with a brief discussion on statistical and practical significance of test results.

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Notes

  1. 1.

    So it is a statistic and a random variable!

References

  1. Mood, A. M., Graybill, F. A., and Boes, D. C. (1974) Introduction to the Theory of Statistics, 3rd ed. New York, McGraw-Hill.

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  2. Arnold, S. F. (1990) Mathematical Statistics. Englewood Cliffs, Prentice-Hall.

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  3. Maisel, A. S., Krishnaswamy, P., Nowak, R. M., McCord, J., Hollander, J. E., Duc, P., Omland, T., Storrow, A. B., Abraham, W. T., and Wu, A. H. B. (2002). Rapid measurement of B-type natriuretic reptide in the emergency diagnosis of heart failure. N. Engl. J. Med. 347(3), 161–167.

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© 2007 Humana Press Inc., Totowa, NJ

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Tu, W. (2007). Basic Principles of Statistical Inference. In: Ambrosius, W.T. (eds) Topics in Biostatistics. Methods in Molecular Biology™, vol 404. Humana Press. https://doi.org/10.1007/978-1-59745-530-5_4

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  • DOI: https://doi.org/10.1007/978-1-59745-530-5_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-531-6

  • Online ISBN: 978-1-59745-530-5

  • eBook Packages: Springer Protocols

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