Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011, 155(2):109-116 | DOI: 10.5507/bp.2011.021

OSTEOBLAST AND GINGIVAL FIBROBLAST MARKERS IN DENTAL IMPLANT STUDIES

Veronika Pivodovaa, Jana Frankovaa, Jitka Ulrichovaa,b
a Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
b Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc

Background: Dental implants are a suitable option for the replacement of some or all missing teeth. Their main function is to secure the stability of the artificial tooth. The implant material interacts with several cell types including osteoblasts, gingival fibroblasts, periodontal ligament fibroblasts and monocytes. The most common material used is pure titanium which is corrosion resistant and has an elasticity modulus similar to that of bone. In recent years, diverse modified titanium surfaces have also been developed. The wound healing around the implant is a complex process that determines how well the host can heal and accept the implanted material. For this reason, search for markers of the biocompatibility of these new materials is paramount. To identify markers found to be suitable for studying the biocompatibility of dental implants.

Methods: Review of Pubmed and Web of Science databases for the years 1958-2010.

Conclusions: The surface of dental implant material should enhance firm attachment of the implant to junctional epithelium, soft connective tissue and bone. For the purposes of dental implant biocompatibility studies, a number of markers produced by osteoblasts or by cells of periodontal ligament have been proposed. In general, the most typical markers for osteoblasts and fibroblasts are alkaline phosphatase and collagen I, respectively. The involvement of both cell types in the inflammatory response is primarily evaluated by determination of tumour necrosis factor α and proinflammatory interleukins.

Keywords: Osteoblasts, Gingival fibroblasts, Extracellular matrix proteins, Dental implants

Received: February 4, 2011; Accepted: March 3, 2011; Published: June 1, 2011  Show citation

ACS AIP APA ASA Harvard Chicago IEEE ISO690 MLA NLM Turabian Vancouver
Pivodova, V., Frankova, J., & Ulrichova, J. (2011). OSTEOBLAST AND GINGIVAL FIBROBLAST MARKERS IN DENTAL IMPLANT STUDIES. Biomedical papers, 155(2), 109-116. doi: 10.5507/bp.2011.021
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Eisenbarth E, Meyle J, Nachtigall W, Breme J. Influence of the surface structure of titanium materials on the adhesion of fibroblasts. Biomaterials 1996;17:1399-1403. Go to original source... Go to PubMed...
    2. Jones FH. Teeth and bones: applications of surface science to dental materials and related biomaterials. Surface Science Reports 2001;42:79-205. Go to original source...
    3. Pier-Francesco A, Adams RJ, Waters MGJ, Williams DW. Titanium surface modification and its effect on the adherence of Porphyromonas gingivalis: an in vitro study. Clinical Oral Implants Research 2006;17:633-637. Go to original source... Go to PubMed...
    4. Cooper LF. A role for surface topography in creating and maintaining bone at titanium endosseous implants. Journal of Prosthetic Dentistry 2000;84:522-534. Go to original source... Go to PubMed...
    5. Schwartz Z, Lohmann CH, Oefinger J, Bonewald LF, Dean DD, Boyan BD. Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage. Adv Dent res 1999;13:38-48. Go to original source... Go to PubMed...
    6. De Angelis E, Ravanetti F, Cacchioli A, Corradi A, Giordano C, Candiani G, Chiesa R, Gabbi C, Borghetti P. Attachment, proliferation and osteogenic response of osteoblast-like cells cultured on titanium treated by a novel multiphase anodic spark deposition process. Journal of Biomedical Materials Research Part B-Applied Biomaterials 2008;88:280-289. Go to original source...
    7. Gersdorff N, Miro X, Roediger M., Geffers R, Toepfer T, Huels A, Miosge N. Gene expression analysis of chronically inflamed and healthy human periodontal ligament cells in vivo. Dental Research Journal 2008;5:5-11.
    8. Inoue M, LeGeros RZ, Hoffman C, Diamond K, Rosenberg PA, Craig RG. Effect of enamel matrix proteins on the phenotype expression of periodontal ligament cells cultured on dental materials. Journal of Biomedical Materials Research Part A 2004;69A:172- 179. Go to original source... Go to PubMed...
    9. Ohno S, Ijiun C, Doi T, Yoneno K, Tanne K. Epression and activity of hyaluronidase in human periodontal ligament fibroblasts. Journal Periodontol 2002;73:1331-1337. Go to original source... Go to PubMed...
    10. Bosshardt DD. Are cementoblasts a subpopulation of osteoblasts or a unique phenotype? Journal of Dental Research 2005;84:390-406. Go to original source... Go to PubMed...
    11. Bruckmann C, Walboomers XF, Matsuzaka K, Jansen JA. Periodontal ligament and gingival fibroblast adhesion to dentinlike textured surfaces. Biomaterials 2005;26:339-346. Go to original source... Go to PubMed...
    12. Lekic P, Sodek J, McCulloch CA. Osteopontin and bone sialoprotein expression in regenerating rat periodontal ligament and alveolar bone. Anatomical Record 1996;244:50-8. Go to original source... Go to PubMed...
    13. Palaiologou AA, Yukna RA, Moses R, Lallier TE. Gingival, dermal, and periodontal ligament fibroblasts express different extracellular matrix receptors. Journal of Periodontology 2001;72:798-807. Go to original source... Go to PubMed...
    14. Biagini G, Checcini L, Pelliccioni GA, Solmi R. In vitro growth of periodontal fibroblasts on treated cementum. Quintessence Int 1992;23:335-340.
    15. Park JC, Kim YB, Kim HJ, Jang HS, Kim HS, Kim BO, Han KY. Isolation and characterization of cultured human periodontal ligament fibroblast-specific cDNAs. Biochemical and Biophysical Research Communications 2001;282:1145-1153. Go to original source... Go to PubMed...
    16. Siebers MC, ter Brugge PJ, Walboomers XF, Jansen JA. Integrins as linker proteins between osteoblasts and bone replacing materials. A critical review. Biomaterials 2005;26:137-146. Go to original source... Go to PubMed...
    17. Steinemann SG. Titanium - the material of choice? Periodontol 2000 1998;17:7-21. Go to original source... Go to PubMed...
    18. Unger RE, Sartoris A, Peters K, Motta A, Migliaresi C, Kunkel M, Bulnheim U, Rychly J, Kirkpatrick CJ. Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials. Biomaterials 2007;28:3965-3976. Go to original source... Go to PubMed...
    19. Berkovitz BKB. The Structure of the Periodontal-Ligament - an Update. European Journal of Orthodontics 1990;12:51-76. Go to original source... Go to PubMed...
    20. Reichenberg E, Redlich M, Cancemi P, Zaks B, Pitaru S, Fontana S, Pucci-Minafra I, Palmon A. Proteomic analysis of protein components in periodontal ligament fibroblasts. Journal of Periodontology 2005;76:1645-1653. Go to original source... Go to PubMed...
    21. Jayaraman M, Meyer U, Buhner M, Joos U, Wiesmann HP. Influence of titanium surfaces on attachment of osteoblast-like cells in vitro. Biomaterials 2004;25:625-631. Go to original source... Go to PubMed...
    22. Erickson HP, Bourdon MA. Tenascin - an Extracellular-Matrix Protein Prominent in Specialized Embryonic-Tissues and Tumors. Annual Review of Cell Biology 1989;5:71-92. Go to original source... Go to PubMed...
    23. Chiquet-Ehrismann R. What distinguishes tenascin from fibronectin? FASEB Journal 1990;4:2598-604. Go to original source... Go to PubMed...
    24. Chiquet-Ehrismann R, Tannheimer M, Koch M, Bruner A, Spring J, Martin D, Baumgartner S, Chiquet M. Tenascin-C expression by fibroblastsis elevated in stressed collagen gels. Journal of Cell Biology 1994;127:1037-45. Go to original source... Go to PubMed...
    25. Chiquet M. Mattisson M, Koch M., Tannheimer M., Chiquet- Ehrismann R. Regulation of extracellular matrix synthesis by mechanical stress. Biochemistry and Cell biology 1996;74:737-44. Go to original source... Go to PubMed...
    26. Borsani E, Salgarello S, Mensi M, Boninsegna R, Stacchiotti A, Rezzani R, Sapelli P, Bianchi R, Rodella LF. Histochemical and immunohistochemical evaluation of gingival collagen and metalloproteinases in peri-implantitis. Acta Histochemica 2005;107:231- 240. Go to original source... Go to PubMed...
    27. Thesleff I, Mackie E, Vainio S, Chiouetehrismann R. Changes in the Distribution of Tenascin during Tooth Development. Development 1987;101:289-296. Go to original source... Go to PubMed...
    28. Lukinmaa PL, Mackie EJ, Thesleff I. Immunohistochemical Localization of the Matrix Glycoproteins - Tenascin and the Ed- Sequence-Containing Form of Cellular Fibronectin - in Human Permanent Teeth and Periodontal-Ligament. Journal of Dental Research 1991;70:19-26. Go to original source... Go to PubMed...
    29. Martinez EF, de Souza SOM, Correa L, de Araujo VC. Immunohistochemical localization of tenascin, fibronectin, and type III collagen in human dental pulp. Journal of Endodontics 2000;26:708-711. Go to original source... Go to PubMed...
    30. Martinez EF, Araujo VC. In vitro immunoexpression of extracellular matrix proteins in dental pulpal and gingival human fibroblasts. International Endodontic Journal 2004;37:749-755. Go to original source... Go to PubMed...
    31. Hynes RO. Fibronectins. Scientific American 1986;254:42-51. Go to original source... Go to PubMed...
    32. Ruoslahti E. Fibronectin. Journal of Oral Pathology & Medicine 1981;10:3-13. Go to original source...
    33. Martinez-Hernandez A, Amenta PS. The basement membrane in pathology. Laboratory Investigation 1983;48:656-77. Go to PubMed...
    34. Yamada KM, Olden K. Fibronectins - Adhesive Glycoproteins of Cell-Surface and Blood. Nature 1978;275:179-184. Go to original source... Go to PubMed...
    35. Lesot H, Osman M, Ruch JV. Immunofluorescent Localization of Collagens, Fibronectin, and Laminin during Terminal Differentiation of Odontoblasts. Developmental Biology 1981;82:371-381. Go to original source... Go to PubMed...
    36. Baum BJ, Wright WE. Demonstration of Fibronectin as a Major Extracellular Protein of Human Gingival Fibroblasts. Journal of Dental Research 1980;59:631-637. Go to original source... Go to PubMed...
    37. Moursi AM, Globus RK, Damsky CH. Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro. Journal of Cell Science 1997;110:2187-2196. Go to original source... Go to PubMed...
    38. Grill V, Sandrucci MA, Basa M, DiLenarda R, Dorigo E, Narducci P, Martelli AM, Delbello G, Bareggi R. The influence of dental metal alloys on cell proliferation and fibronectin arrangement in human fibroblast cultures. Archives of Oral Biology 1997;42:641- 647. Go to original source... Go to PubMed...
    39. Aubin JE, Liu F, Malaval L, Gupta AK. Osteoblast and Chondroblast Differentiation. Bone 1995;17:S77-S83. Go to original source... Go to PubMed...
    40. Moursi AM, Damsky CH, Lull J, Zimmerman D, Doty SB, Aota SI, Globus RK. Fibronectin regulates calvarial osteoblast differentiation. Journal of Cell Science 1996;109:1369-1380. Go to original source... Go to PubMed...
    41. Francois P, Vaudaux P, Taborelli M, Tonetti M, Lew DP, Descouts P. Influence of surface treatments developed for oral implants on the physical and biological properties of titanium .2. Adsorption isotherms and biological activity of immobilized fibronectin. Clinical Oral Implants Research 1997;8:217-225. Go to original source... Go to PubMed...
    42. Van Amerongen JP, Tonino GJ. The concentration, extractability and characterization of collagenin human dental pulp. Archives of oral biology 1983;28:339-45. Go to original source... Go to PubMed...
    43. Shuttleworth CA, Berry L, Wilson N. Collagen-Synthesis in Rabbit Dental-Pulp Fibroblast-Cultures. Archives of oral biology 1980;25:201-205. Go to original source... Go to PubMed...
    44. Narayanan AS, Page RC. Connective Tissues of the Periodontium - a Summary of Current Work. Collagen and Related Research 1983;3:33-64. Go to original source... Go to PubMed...
    45. Linde A. Session II: cells and extracellular matrices of dental pulp. The extracellular matrix of the dental pulp and dentin. Journal of Dental Research 1985;64:523-29. Go to original source... Go to PubMed...
    46. Scott PG, Veis A. Cyanogen-Bromide Peptides of Bovine Soluble and Insoluble Collagens .1. Characterization of Peptides from Soluble Type-I Collagen by Sodium Dodecylsulphate Polyacrylamide-Gel Electrophoresis. Connective Tissue Research 1976;4:107-116. Go to original source... Go to PubMed...
    47. Morra M, Cassinelli C, Cascardo G, Cahalan P, Cahalan L, Fini M, Giardino R. Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies. Biomaterials 2003;24:4639-4654. Go to original source... Go to PubMed...
    48. Wendel M, Sommarin Y, Heinegard D. Bone matrix proteins: Isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone. Journal of Cell Biology 1998;141:839-847. Go to original source... Go to PubMed...
    49. Lallier TE, Spencer A, Fowler MM. Transcript profiling of periodontal fibroblasts and osteoblasts. Journal of Periodontology 2005;76:1044-1055. Go to original source... Go to PubMed...
    50. Fisher LW, Termine JD. Noncollagenous Proteins Influencing the Local Mechanisms of Calcification. Clinical Orthopaedics and Related Research 1985:362-385. Go to original source... Go to PubMed...
    51. Ingram RT, Clarke BL, Fisher LW, Fitzpatrick LA. Distribution of Noncollagenous Proteins in the Matrix of Adult Human Bone - Evidence of Anatomic and Functional-Heterogeneity. Journal of Bone and Mineral Research 1993;8:1019-1029. Go to original source... Go to PubMed...
    52. Robey P. Vertebrate mineralized matrix proteins structure and function. Connective Tissue Research 1996;35:131-6. Go to original source... Go to PubMed...
    53. Romberg RW, Werness PG, Riggs BL, Mann KG. Inhibition of Hydroxyapatite Crystal-Growth by Bone-Specific and Other Calcium-Binding Proteins. Biochemistry 1986;25:1176-1180. Go to original source... Go to PubMed...
    54. Kelm RJ, Swords NA, Orfeo T, Mann KG. Osteonectin in Matrix Remodeling - a Plasminogen-Osteonectin-Collagen Complex. Journal of Biological Chemistry 1994;269:30147-30153. Go to original source...
    55. Fassmann A, Izakovičová-Hollá L, Slapnička J. Kostní tkáňové inženýrství v orofaciální oblasti. Brno: Nucleus HK; 2006.
    56. Termine JD, Kleinman HK, Whitson SW, Conn KM, Mcgarvey ML, Martin GR. Osteonectin, a Bone-Specific Protein Linking Mineral to Collagen. Cell 1981;26:99-105. Go to original source... Go to PubMed...
    57. Noda M, Yoon K, Rodan GA, Koppel DE. High Lateral Mobility of Endogenous and Transfected Alkaline-Phosphatase - a Phosphatidylinositol-Anchored Membrane-Protein. Journal of Cell Biology 1987;105:1671-1677. Go to original source... Go to PubMed...
    58. Low MG. Glycosyl-Phosphatidylinositol - a Versatile Anchor for Cell-Surface Proteins. Faseb Journal 1989;3:1600-1608. Go to original source... Go to PubMed...
    59. Abe T, Hara Y, Abe Y, Aida Y, Maeda K. Serum or growth factor deprivation induces the expression of alkaline phosphatase in human gingival fibroblasts. Journal of Dental Research 1998;77:1700- 1707. Go to original source... Go to PubMed...
    60. Harris H. The Human Alkaline-Phosphatases - What We Know and What We Dont Know. Clinica Chimica Acta 1990;186:133-150. Go to original source...
    61. Leung KS, Fung KP, Sher AHL, Li CK, Lee KM. Plasma Bone- Specific Alkaline-Phosphatase as an Indicator of Osteoblastic Activity. Journal of Bone and Joint Surgery-British Volume 1993;75:288-292. Go to original source... Go to PubMed...
    62. Piattelli A, Scarano A, Corigliano M, Piattelli M. Effects of alkaline phosphatase on bone healing around plasma-sprayed titanium implants: A pilot study in rabbits. Biomaterials 1996;17:1443-1449. Go to original source... Go to PubMed...
    63. Vorbrodt A. Histochemically Demonstrable Phosphatases and Protein Synthesis. Experimental Cell Research 1958;15:1-20. Go to original source... Go to PubMed...
    64. Fullmer H, The histochemistry of the connective tissue. In: International review of connective tissue research, H. DA, Editor. 1965, Academic Press: New York. Go to original source...
    65. Burgess TL, Qian YX, Kaufman S, Ring BD, Van G, Capparelli C, Kelley M, Hsu H, Boyle WJ, Dunstan CR, Hu S, Lacey DL. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. Journal of Cell Biology 1999;145:527-538. Go to original source... Go to PubMed...
    66. Jimi E, Akiyama S, Tsurukai T, Okahashi N, Kobayashi K, Udagawa N, Nishihara T, Takahashi N, Suda T. Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. Journal of Immunology 1999;163:434-442. Go to original source... Go to PubMed...
    67. Luvizuto ER, Queiroz TP, Dias SMD, Okamoto T, Dornelles RCM, Garcia IR, Okamoto R. Histomorphometric analysis and immunolocalization of RANKL and OPG during the alveolar healing process in female ovariectomized rats treated with oestrogen or raloxifene. Archives of Oral Biology 2010;55:52-59. Go to original source... Go to PubMed...
    68. Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM, Manolagas SC. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. Journal of Clinical Investigation 1999;104:439-446. Go to original source... Go to PubMed...
    69. El-Ghannam A, Starr L, Jones J. Laminin-5 coating enhances epithelial cell attachment, spreading, and hemidesmosome assembly on Ti-6Al-4V implant material in vitro. Journal of Biomedical Materials Research 1998;41:30-40. Go to original source... Go to PubMed...
    70. Gordon JAR, Tye CE, Sampaio AV, Underhill TM, Hunter GK, Goldberg HA. Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro. Bone 2007;41:462-473. Go to original source... Go to PubMed...
    71. Xu L, Anderson AL, Lu QH, Wang JX. Role of fibrillar structure of collagenous carrier in bone sialoprotein-mediated matrix mineralization and osteoblast differentiation. Biomaterials 2007;28:750-761. Go to original source... Go to PubMed...
    72. Goto T, Yoshinari M, Kobayashi S, Tanaka T. The initial attachment and subsequent behavior of osteoblastic cells and oral epithelial cells on titanium. Bio-Medical Materials and Engineering 2004;14:537-544. Go to PubMed...
    73. Diener A, Nebe B, Luthen F, Becker P, Beck U, Neumann HG, Rychly J. Control of focal adhesion dynamics by material surface characteristics. Biomaterials 2005;26:383-392. Go to original source... Go to PubMed...
    74. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. Journal of Cell Science 2006;119:3901-3903. Go to original source... Go to PubMed...
    75. Hynes RO. Integrins - Versatility, Modulation, and Signaling in Cell-Adhesion. Cell 1992;69:11-25. Go to original source... Go to PubMed...
    76. Schoenwaelder SM, Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Current Opinion in Cell Biology 1999;11:274-286. Go to original source... Go to PubMed...
    77. Humphries MJ. The Molecular-Basis and Specificity of Integrin Ligand Interactions. Journal of Cell Science 1990;97:585-592. Go to original source... Go to PubMed...
    78. Plow EF, Haas TK, Zhang L, Loftus J, Smith JW. Ligand binding to integrins. Journal of Biological Chemistry 2000;275:21785-21788. Go to original source... Go to PubMed...
    79. Kramer PR, Janik-Keith A, Cai Z, Ma S, Watanabe I. Integrin mediated attachment of periodontal ligament to titanium surfaces. Dental Materials 2009;25:877-883. Go to original source... Go to PubMed...
    80. Eslami A. The role of integrins in wound healing. The Science Creative Quarterly 2005 [http://www.scq.ubc.ca/the-role-of-integrins- in-wound-healing/].
    81. Bois PRJ, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T. The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin. Journal of Biological Chemistry 2006;281:7228- 7236. Go to original source... Go to PubMed...
    82. Takahashi H, Mitsushima M, Okada N, Ito T, Aizawa S, Akahane R, Umemoto T, Ueda K, Kioka N. Role of interaction with vinculin in recruitment of vinexins to focal adhesions. Biochemical and Biophysical Research Communications 2005;336:239-246. Go to original source... Go to PubMed...
    83. Otto JJ. Vinculin. Cell Motility and the Cytoskeleton 1990;16:1-6. Go to original source... Go to PubMed...
    84. Saunders RM, Holt MR, Jennings L, Sutton DH, Barsukov IL, Bobkov A, Liddington RC, Adamson EA, Dunn GA, Critchley DR. Role of vinculin in regulating focal adhesion turnover. European Journal of Cell Biology 2006;85:487-500. Go to original source... Go to PubMed...
    85. Ziegler WH, Liddington RC, Critchley DR. The structure and regulation of vinculin. Trends in Cell Biology 2006;16:453-460. Go to original source... Go to PubMed...
    86. Tipton DA, Lyle B, Babich H, Dabbous MK. In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells. Toxicology in Vitro 2003;17:301-310. Go to original source... Go to PubMed...
    87. Petković AB, Matić SM, Stamatović NV, Vojvodić DV, Todorović TM, Lazić ZR, Kozomara RJ. Proinflammatory cytokines (1L- 1 and TNF-) and chemokines (1L-8 and MIP-1) as markers of peri-implant tissue condition. International journal of oral and maxillofacial surgery 2010;10. Go to original source... Go to PubMed...
    88. Roberts FA, McCaffery KA, Michalek SM. Profile of cytokine mRNA expression in chronic adult periodontitis. Journal of Dental Research 1997;76:1833-1839. Go to original source... Go to PubMed...
    89. Agarwal S, Chandra CS, Piesco NP, Langkamp HH, Bowen L, Baran C. Regulation of periodontal ligament cell functions by interleukin- 1 beta. Infection and Immunity 1998;66:932-937. Go to original source... Go to PubMed...
    90. Imatani T, Kato T, Okuda K. Production of inflammatory cytokines by human gingival fibroblasts stimulated by cell-surface preparations of Porphyromonas gingivalis. Oral Microbiology and Immunology 2001;16:65-72. Go to original source... Go to PubMed...
    91. Quintero JC, Langkamp HH, Johns LP, Piesco NP, Agarwal S. Tumor-Necrosis-Factor-Alpha Regulates Expression of Lps Receptors on Periodontal-Ligament Cells. Journal of Dental Research 1995;74:540-540. Go to original source... Go to PubMed...
    92. Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. Journal of Periodontology 2003;74:391-401. Go to original source... Go to PubMed...
    93. Nishikawa M, Yamaguchi Y, Yoshitake K, Saeki Y. Effects of TNF alpha and prostaglandin E-2 on the expression of MMPs in human periodontal ligament fibroblasts. Journal of Periodontal Research 2002;37:167-176. Go to original source... Go to PubMed...
    94. Yongchaitrakul T, Lertsirirangson K, Pavasant P. Human periodontal ligament cells secrete macrophage colony-stimulating factor in response to tumor necrosis factor-alpha in vitro. Journal of Periodontology 2006;77:955-962. Go to original source... Go to PubMed...
    95. Graves DT. The potential role of chemokines and inflammatory cytokines in periodontal disease progression. Clinical Infectious Diseases 1999;28:482-90. Go to original source... Go to PubMed...
    96. Feldmann M, Brennan FM, Elliott MJ, Williams RO, Maini RN. TNF alpha is an effective therapeutic target for rheumatoid arthritis. Ann N Y Acad Sci 1995;766:272-8. Go to original source... Go to PubMed...
    97. Raine CS. Multiple-Sclerosis - Tnf Revisited, with Promise. Nature Medicine 1995;1:211-214. Go to original source... Go to PubMed...
    98. Rapala K. The effect of tumor necrosis factor-alpha on wound healing - An experimental study. Annales Chirurgiae Et Gynaecologiae 1996;85:9.
    99. Takemura A, Nakagawa I, Kawai S, Inaba H, Kato T, Hamada S, Amano A. Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells. Journal of Periodontology 2006;77:883-890. Go to original source... Go to PubMed...
    100. Yucel-Lindberg T, Brunius G. Epidermal growth factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1 beta. Archives of Oral Biology 2006;51:892-898. Go to original source... Go to PubMed...
    101. Domeij H, Modeer T, Quezada HC, Yucel-Lindberg T. Cell expression of MMP-1 and TIMP-1 in co-cultures of human gingival fibroblasts and monocytes: The involvement of ICAM- 1. Biochemical and Biophysical Research Communications 2005;338:1825-1833. Go to original source... Go to PubMed...
    102. Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S. The role of matrix metalloproteinases (MMPs) in human caries. Journal of Dental Research 2006;85:22-32. Go to original source... Go to PubMed...
    103. Bair EL, Massey CP, Tran NL, Borchers AH, Heimark RL, Cress AE, Bowden GT. Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in clocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts. Experimental Cell Research 2001;270:259-267. Go to original source... Go to PubMed...
    104. Schierano G, Bassi F, Gassino G, Mareschi K, Bellone G, Preti G. Cytokine production and bone remodeling in patients wearing overdentures on oral implants. Journal of Dental Research 2000;79:1675-1682. Go to original source... Go to PubMed...
    105. Schierano G, Bellone G, Manzella C, Preti G, Emanuelli G. In vitro effect of transforming growth factor-beta on adhesion molecule expression by human gingival fibroblasts cultured in the presence of a titanium abutment. Journal of Periodontology 2001;72:1658- 1665. Go to original source... Go to PubMed...
    106. Crawford JM. Distribution of ICAM-1, LFA-3 and HLA-DR in Healthy and Diseased Gingival Tissues. Journal of Periodontal Research 1992;27:291-298. Go to original source... Go to PubMed...
    107. Crawford JM, Hopp B. Junctional Epithelium Expresses the Intercellular-Adhesion Molecule Icam-1. Journal of Periodontal Research 1990;25:254-256. Go to original source... Go to PubMed...
    108. Stepanova II. The use of fibroblasts in periodontology and implantology. Bulletin of Experimental Biology and Medicine 2007;144:147-150. Go to original source... Go to PubMed...
    109. Derringer KA, Linden RWA. Vascular endothelial growth factor, fibroblast growth factor 2, platelet derived growth factor and transforming growth factor beta released in human dental pulp following orthodontic force. Archives of oral biology 2004;49:631- 641. Go to original source... Go to PubMed...
    110. Cury PR, de Araujo VC, Canauez F, Furuse C, Leite KRM, de Araujo NS. The effect of epidermal growth factor on matrix metalloproteinases and tissue inhibitors of metalloproteinase gene expression in cultured human gingival fibroblasts. Archives of oral biology 2007;52:585-590. Go to original source... Go to PubMed...
    111. Kawahara H, Kawahara D, Mimura Y, Takashima Y, Ong JL. Morphologic studies on the biologic seal of titanium implants. Report II.In vivo study on the defending mechanism of epithelial adhesion/attachment against invase factors. International Journal of Oral & Maxillofacial Implants 1998;13:465-473.
    112. Mustafa K, Lopez BS, Hultenby K, Wennerberg A, Arvidson K. Attachment and proliferation of human oral fibroblasts to titanium surfaces blasted with TiO2 particles - A scanning electron microscopic and histomorphometric analysis. Clinical Oral Implants Research 1998;9:195-207. Go to original source... Go to PubMed...

    Return to the content