Abstract
Lymphatic metastasis is a continuous and complicated process. The detailed mechanisms of lymphatic metastasis are still not very clear, despite considerable research efforts in recent years. Previously, it was commonly accepted that there were no lymphatic vessels in the primary tumor. However, recent studies have demonstrated that lymphatic vessels are detectable in certain types of cancer, and more and more evidence has shown that cancer cells invade into local lymph nodes mainly via peritumoral lymphatic vessels. Moreover, activated endothelial cells may also be important, having an influence on lymphatic metastasis of cancer cells. This article, based on recent research findings, provides an in‐depth discussion of the relationship between lymphangiogenesis, tumor‐derived lymphatic endothelial cells and lymphatic metastasis in head and neck cancer.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zhang, Z., Helman, J. & Li, L. Lymphangiogenesis, Lymphatic Endothelial Cells and Lymphatic Metastasis in Head and Neck Cancer — A Review of Mechanisms. Int J Oral Sci 2, 5–14 (2010). https://doi.org/10.4248/IJOS10006
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.4248/IJOS10006
Keywords
This article is cited by
-
Understanding the development, pathogenesis, and injury response of meningeal lymphatic networks through the use of animal models
Cellular and Molecular Life Sciences (2023)
-
Prognostic Relevance of Lymphatic Vessel Density in Squamous Cell Carcinomas of the Oral Cavity: A Systematic Review and Meta-Analysis
Head and Neck Pathology (2022)
-
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
Oncogenesis (2021)
-
Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System
Current Treatment Options in Neurology (2020)
-
Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain
Frontiers of Medicine (2020)