1Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
2Department of Biochemistry, Catholic Kwandong University College of Medicine, Gangneung, Korea.
3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Copyright © 2016 Korean Diabetes Association
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
Adapted from ClinicalTrials.gov [25].
5-HT, 5-hydroxytryptamine; FDA, Food and Drug Administration; DA, dopamine; NA, noradrenaline.
Study | Ethnicity | Sample size, n | SNP ID | Gene | Chromosome | Allele | Association |
---|---|---|---|---|---|---|---|
Kwak et al. (2012) [60] | Korean | 8,842 | rs623580 | TPH1 | 11 | A/T | BMI and WC |
Rosmond et al.(2002) [61] | Swedish | 284 | rs6311 | HTR2A | 13 | C/T | BMI, WHR |
Halder et al. (2007) [62] | European | 934 | rs6311 | HTR2A | 13 | C/T | Central obesity, metabolic syndrome |
rs2070040 | HTR2A | 13 | A/G | ||||
Li et al. (2014) [63] | European | 1,982 | rs912127 | HTR2A | 13 | A/G | BMI |
American | rs1745837 | HTR2A | 13 | C/T | |||
Opgen-Rhein et al. (2010) [64] | German | 128 | rs498207 | HTR2C | X | C/T | Weight gain |
Suviolahti et al. (2003) [65] | Finnish, | 2,104 | rs2011162 | SLC6A14 | X | C/G | BMI |
Swedish | rs2071877 | SLC6A14 | X | C/T | |||
Corpeleijn et al. (2010) [66] | European | 722 | rs2011162 | SLC6A14 | X | C/G | BMI, fat oxidation in women |
Chen et al. (2013) [67] | Chinese | 478 | rs1018079 | SLC18A1 | 8 | A/G | BMI |
rs11214769 | HTR3B | 11 | A/G | ||||
rs2224721 | HTR2A | 13 | A/C | ||||
rs4911871 | HTR2C | X | A/G |