Abstract
Posterior parietal cortex lesions have been associated with both hemispatial neglect and spatialupdating deficits. Currently, the relation between these processes remains poorly understood. We tested the ability of parietal patients with neglect to update remembered target locations during passive whole-body rotations. The rotations and manual pointing responses were executed with and without vision. During the rotation, the remembered location stayed on the same side of the body midline or crossed the midline. Parietal patients generally underestimated rotations, as compared with control groups, but updated targets equally well on either side of the body midline, regardless of the amount of updating required. Once parietal patients have localized a target, they can use self-motion information to update its location, even if it passes into the region they typically neglect. This lack of contralesional updating effects contrasts with impairments in eye position updating found in previous work with parietal patients.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Aguirre, G. K., & D'Esposito, M. (1999). Topographical disorientation: A synthesis and taxonomy. Brain, 122, 1613–1628.
Andersen, R. A., Snyder, L. H., Bradley, D. C., & Xing, J. (1997). Multimodal representation of space in the posterior parietal cortex and its use in planning movements. Annual Review of Neuroscience, 20, 303–330.
Behrmann, M., Ghiselli-Crippa, T., & Di Matteo, I. (2002). Impaired initiation but not execution of eye movements in patients with hemispatial neglect. Behavioral Neurology, 13, 1–16.
Behrmann, M., Nelson, J., & Sekuler, E. (1998). Visual complexity in letter-by-letter reading: “Pure” alexia is not so pure. Neuropsychologia, 36, 1115–1132.
Bisiach, E., Pattini, P., Rusconi, M. L., Ricci, R., & Bernardini, B. (1997). Unilateral neglect and space constancy during passive locomotion. Cortex, 33, 313–322.
Bisiach, E., & Vallar, G. (2001). Unilateral neglect in humans. In F. Boller & J. Grafman (Eds.), Handbook of neuropsychology (2nd ed., Vol. 1, pp. 459–502). Amsterdam: North-Holland.
Blouin, J., Gauthier, G. M., & Vercher, J.-L. (1995). Failure to update the egocentric representation of the visual space through labyrinthine signal. Brain & Cognition, 29, 1–22.
Bonda, E., Petrides, M., Frey, S., & Evans, A. (1995). Neural correlates of mental transformations of the body-in-space. Proceedings of the National Academy of Sciences, 92, 11180–11184.
Colby, C. L., Duhamel, J. R., & Goldberg, M. E. (1996). Visual, presaccadic, and cognitive activation of single neurons in monkey lateral intraparietal area. Journal of Neurophysiology, 76, 2841–2852.
Colby, C. L., & Goldberg, M. E. (1999). Space and attention in parietal cortex. Annual Review of Neuroscience, 22, 319–349.
Day, B. L., & Lyon, I. N. (2000). Voluntary modification of automatic arm movements evoked by motion of a visual target. Experimental Brain Research, 130, 159–168.
Desmurget, M., Epstein, C. M., Turner, R. S., Prablanc, C., Alexander, G. E., & Grafton, S. T. (1999). Role of the posterior parietal cortex in updating reaching movements to a visual target. Nature Neuroscience, 2, 563–567.
DeSouza, J. F. X., Dukelow, S. P., Gati, J. S., Manon, R. S., Andersen, R. A., & Vilis, T. (2000). Eye position signal modulates a human parietal pointing region during memory guided movements. Journal of Neuroscience, 20, 5835–5840.
Duhamel, J. R., Goldberg, M. E., Fitzgibbon, E. J., Sirigu, A., & Grafman, J. (1992). Saccadic dysmetria in a patient with a right frontoparietal lesion: The importance of corollary discharge for accurate spatial behaviour. Brain, 115, 1387–1402.
Farrell, M. J. (1996). Topographical disorientation. Neurocase, 2, 509–520.
Farrell, M. J., & Robertson, I. H. (2000). The automatic updating of egocentric spatial relationships and its impairment due to right posterior cortical lesions. Neuropsychologia, 38, 585–595.
Friberg, L., Olsen, T. S., Roland, P. E., Paulson, O. B., & Lassen, N. A. (1985). Focal increase of blood flow in the cerebral cortex of man during vestibular stimulation. Brain, 108, 609–623.
Heide, W., Blankenburg, M., Zimmermann, E., & Kompf, D. (1995). Cortical control of double-step saccades: Implications for spatial orientation. Annals of Neurology, 38, 739–748.
Israël, I., Rivaud, S., Gaymard, B., Berthoz, A., & Pierrot-Deseilligny, C. (1995). Cortical control of vestibular-guided saccades in man. Brain, 118, 1169–1183.
Karnath, H.-O. (1994). Subjective body orientation in neglect and the interactive contribution of neck muscle proprioception and vestibular stimulation. Brain, 117, 1001–1012.
Karnath, H.-O., & Ferber, S. (1999). Is space representation distorted in neglect? Neuropsychologia, 37, 7–15.
Karnath, H.-O., Ferber, S., & Himmelbach, M. (2001). Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature, 411, 951–953.
Karnath, H.-O., & Perenin, M.-T. (1998). Tactile exploration of peripersonal space in patients with neglect. NeuroReport, 9, 2273–2277.
Lobel, E., Kleine, J. F., Bihan, D. L., Leroy-Willig, A., & Berthoz, A. (1998). Functional MRI of galvanic vestibular stimulation. Journal of Neurophysiology, 80, 2699–2709.
Loomis, J. M., Klatzky, R. L., Golledge, R. G., & Philbeck, J. W. (1999). Human navigation by path integration. In R. G. Golledge (Ed.), Wayfinding behavior: Cognitive mapping and other spatial processes (pp. 125–151). Baltimore: Johns Hopkins University Press.
Mapelli, D., & Behrmann, M. (1997). The role of color in object recognition: Evidence from visual agnosia. Neurocase, 3, 237–247.
Milner, A. D., & Goodale, M. A. (1995). The visual brain in action. Oxford: Oxford University Press.
Niemeier, M., & Karnath, H.-O. (2000). Exploratory saccades show no direction-specific deficit in neglect. Neurology, 54, 515–518.
Perenin, M.-T., & Vighetto, A. (1988). Optic ataxia: A specific disruption in visuomotor mechanisms: I. Different aspects of the deficit in reaching for objects. Brain, 111, 643–674.
Petit, L., Orssaud, C., Tzourio, N., Mazoyer, B., & Berthoz, A. (1997). Superior parietal lobule involvement in the representation of visual space: A PET review. In P. Thier & H.-O. Karnath (Eds.), Parietal lobe contributions to orientation in 3D space (pp. 77–91). Heidelberg: Springer-Verlag.
Philbeck, J. W., Behrmann, M., Black, S. E., & Ebert, P. (2000). Intact spatial updating during locomotion after right posterior parietal lesions. Neuropsychologia, 38, 950–963.
Pisella, L., Grea, H., Tilikete, C., Vighetto, A., Desmurget, M., Rode, G., Boisson, D., & Rossetti, Y. (2000). An “automatic pilot” for the hand in human posterior parietal cortex: Toward reinterpreting optic ataxia. Nature Neuroscience, 3, 729–736.
Pizzamiglio, L., Iaria, G., Berthoz, A., Galati, G., & Guariglia, C. (in press). Navigation in neglect patients. In H.-O. Karnath, A. D. Milner, & G. Vallar (Eds.), The cognitive and neural bases of neglect. Oxford: Oxford University Press.
Poucet, B. (1993). Spatial cognitive maps in animals: New hypotheses on their structure and neural mechanisms. Psychological Review, 100, 163–182.
Riddoch, M. J., & Humphreys, G. W. (1983). The effect of cueing on unilateral neglect. Neuropsychologia, 21, 589–599.
Rieser, J. J. (1989). Access to knowledge of spatial structure at novel points of observation. Journal of Experimental Psychology: Learning, Memory, & Cognition, 15, 1157–1165.
Rode, G., Charles, N., Perenin, M. T., Vighetto, A., Trillet, M., & Aimard, G. (1992). Partial remission of hemiplegia and somatoparaphrenia through vestibular stimulation in a case of unilateral neglect. Cortex, 28, 203–208.
Rode, G., & Perenin, M. T. (1994). Temporary remission of representational hemineglect through vestibular stimulation. NeuroReport, 5, 869–872.
Sirigu, A., Duhamel, J.-R., Cohen, L., Pillon, B., Dubois, B., & Agid, Y. (1996). The mental representation of hand movements after parietal cortex damage. Science, 273, 1564–1568.
Snyder, L. H., Batista, A. P., & Andersen, R. A. (1997). Coding of intention in the posterior parietal cortex. Nature, 386, 167–170.
Stein, J. F. (1992). The representation of egocentric space in posterior parietal cortex. Behavioral & Brain Sciences, 15, 691–700.
Tropper, J., Jones, G. M., Bloomberg, J., & Fadlallah, H. (1991). Vestibular perceptual deficits in patients with parietal lobe lesions: A preliminary study. Acta Oto-Laryngologica, Suppl. 481, 528–533.
Uemura, T., Arai, Y., & Shimazaki, C. (1980). Eye-head coordination during lateral gaze in normal subjects. Acta Oto-Laryngologica, 90, 191–198.
Vallar, G. (1998). Spatial hemineglect in humans. Trends in Cognitive Sciences, 2, 87–96.
Vallar, G., Guariglia, C., & Rusconi, M. L. (1997). Modulation of the neglect syndrome by sensory stimulation. In P. Thier & H.-O. Karnath (Eds.), Parietal lobe contributions to orientation in 3D space (pp. 555–578). Heidelberg: Springer-Verlag.
Vecera, S. P., & Behrmann, M. (1997). Spatial attention does not require preattentive grouping. Neuropsychology, 11, 30–43.
Vitte, E., Derosier, C., Caritu, Y., Berthoz, A., Hasboun, D., & Soulie, D. (1996). Activation of the hippocampal formation by vestibular stimulation: A functional magnetic resonance imaging study. Experimental Brain Research, 112, 523–526.
Wilson, B., Cockburn, J., & Halligan, P. (1987). Behavioral inattention test. Bury St. Edmunds, U.K.: Thames Valley Test Company.
Wolpert, D. M., & Ghahramani, Z. (2000). Computational principles of movement neuroscience. Nature Neuroscience, 3 (Suppl.), 1212–1217.
Wolpert, D. M., Goodbody, S. J., & Husain, M. (1998). Maintaining internal representations: The role of the human superior parietal lobe. Nature Neuroscience, 1, 529–533.
Yardley, L., Gardner, M., Lavie, N., & Gresty, M. (1999). Attentional demands of perception of passive self-motion in darkness. Neuropsychologia, 37, 1293–1301.
Zacks, J., Rypma, B., Gabrieli, J. D. E., Tversky, B., & Glover, G. H.v (1999). Imagined transformations of bodies: An fMRI investigation. Neuropsychologia, 37, 1029–1040.
Author information
Authors and Affiliations
Corresponding author
Additional information
A preliminary report of this work was presented in November, 1999, at the 40th Annual Meeting of the Psychonomic Society in Los Angeles. This research was supported by NIH Grant F32 MH11791 and James S. McDonnell Foundation Grant 97-17 to J.W.P. and by NIH Grant RO1 MH54246 to M.B.
Rights and permissions
About this article
Cite this article
Philbeck, J.W., Behrmann, M. & Loomis, J.M. Updating of locations during whole-body rotations in patients with hemispatial neglect. Cognitive, Affective, & Behavioral Neuroscience 1, 330–343 (2001). https://doi.org/10.3758/CABN.1.4.330
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.3758/CABN.1.4.330