Abstract
Research on the neural basis that underlies decision making in humans has revealed that these processes are mediated by distributed neural networks that incorporate different regions of the frontal lobes, the amygdala, the ventral striatum, and the dopamine system. In the present article, we review recent studies in rodents investigating the contribution of these systems to different forms of cost-benefit decision making and focus on evaluations related to delays, effort, or risks associated with certain rewards. Anatomically distinct regions of the medial and orbital prefrontal cortex make dissociable contributions to different forms of decision making, although lesions of these regions can induce variable effects, depending on the type of tasks used to assess these functions. The basolateral amygdala and the nucleus accumbens play a more fundamental role in these evaluations, helping an organism overcome different costs to obtain better rewards. Dopamine activity biases behavior toward more costly yet larger rewards, although abnormal increases in dopamine transmission can exert opposing actions on different types of decision making. The fact that similar neural circuits are recruited to solve these types of problems in both humans and animals suggests that animal models of decision making will prove useful in elucidating the mechanisms mediating these processes.
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Acheson, A., Farrar, A. M., Patak, M., Hausknecht, K. A., Kieres, A. K., Choi, S., et al. (2006). Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behavioural Brain Research, 173, 217–228.
Balleine, B. W., & Dickinson, A. (1998). Goal-directed instrumental action: Contingency and incentive learning and their cortical substrates. Neuropharmacology, 37, 407–419.
Barch, D. M., Braver, T. S., Akbudak, E., Conturo, T., Ollinger, J., & Snyder, A. (2001). Anterior cingulate cortex and response conflict: Effects of response modality and processing domain. Cerebral Cortex, 11, 837–848.
Barch, D. M., Braver, T. S., Nystrom, L. E., Forman, S. D., Noll, D. C., & Cohen, J. D. (1997). Dissociating working memory from task difficulty in human prefrontal cortex. Neuropsychologia, 35, 1373–1380.
Baxter, M. G., Parker, A., Lindner, C. C., Izquierdo, A. D., & Murray, E. A. (2000). Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex. Journal of Neuroscience, 20, 4311–4319.
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50, 7–15.
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999). Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. Journal of Neuroscience, 19, 5473–5481.
Bechara, A., Damasio, H., Tranel, D., & Anderson, S. W. (1998). Dissociation of working memory from decision making within the human prefontal cortex. Journal of Neuroscience, 18, 428–437.
Bizot, J. C., Le Bihan, C., Puech, A. J., Hamon, M., & Thiebot, M. H. (1999). Serotonin and tolerance to delay of reward in rats. Psychopharmacology, 146, 400–412.
Blair, K., Marsh, A. A., Morton, J., Vythilingam, M., Jones, M., Mondillo, K., et al. (2006). Choosing the lesser of two evils, the better of two goods: Specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choice. Journal of Neuroscience, 26, 11379–11386.
Boulougouris, V., Dalley, J. W., & Robbins, T. W. (2007). Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat. Behavioural Brain Research, 179, 219–228.
Brand, M., Grabenhorst, F., Starcke, K., Vandekerckhove, M. M., & Markowitsch, H. J. (2007). Role of the amygdala in decisions under ambiguity and decisions under risk: Evidence from patients with Urbach-Wiethe disease. Neuropsychologia, 45, 1305–1317.
Cardinal, R. N., Daw, N., Robbins, T. W., & Everitt, B. J. (2002). Local analysis of behavior in the adjusting-delay task for assessing choice of delayed reinforcement. Neural Networks, 15, 617–634.
Cardinal, R. N., & Howes, N. J. (2005). Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats. BMC Neuroscience, 6, 37.
Cardinal, R. N., Parkinson, J. A., Marbini, H. D., Toner, A. J., Bussey, T. J., Robbins, T. W., & Everitt, B. J. (2003). Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats. Behavioral Neuroscience, 117, 566–587.
Cardinal, R. N., Pennicott, D. R., Sugathapala, C. L., Robbins, T. W., & Everitt, B. J. (2001). Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science, 292, 2499–2501.
Cardinal, R. N., Robbins, T. W., & Everitt, B. J. (2000). The effects of d-amphetamine, chlordiazepoxide, alpha-flupenthixol and behav ioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats. Psychopharmacology, 152, 362–375.
Chudasama, Y., Passetti, F., Rhodes, S. E. V., Lopian, D., Desai, A., & Robbins, T. W. (2003). Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: Differential effects on selectivity, impulsivity and compulsivity. Behavioural Brain Research, 146, 105–119.
Chudasama, Y., & Robbins, T. W. (2003). Dissociable contributions of the orbitofrontal and infralimbic cortex to Pavlovian autoshaping and discrimination reversal learning: Further evidence for the functional heterogeneity of the rodent frontal cortex. Journal of Neuroscience, 23, 8771–8780.
Clark, L., Manes, F., Antoun, N., Sahakian, B. J., & Robbins, T. W. (2003). The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage. Neuropsychologia, 41, 1474–1483.
Cole, B. J., & Robbins, T. W. (1989). Effects of 6-Hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats—Implications for theories of selective attention and arousal. Behavioural Brain Research, 33, 165–179.
Cools, R., Barker, R. A., Sahakian, B. J., & Robbins, T. W. (2003). L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson’s disease. Neuropsychologia, 41, 1431–1441.
Corbit, L. H., & Balleine, B. W. (2005). Double dissociation of basolateral and central amygdala lesions on the general and outcomespecific forms of Pavlovian-instrumental transfer. Journal of Neuroscience, 25, 962–970.
Cousins, M. S., Wei, W., & Salamone, J. D. (1994). Pharmacological characterization of performance on a concurrent lever pressing/ feeding choice procedure: Effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs. Psychopharmacology, 116, 529–537.
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004). Prefrontal executive and cognitive functions in rodents: Neural and neurochemical substrates. Neuroscience & Biobehavioral Reviews, 28, 771–784.
Dietrich, A., & Allen, J. D. (1998). Functional dissociation of the prefrontal cortex and the hippocampus in timing behavior. Behavioral Neuroscience, 112, 1043–1047.
Evenden, J. L., & Ryan, C. N. (1996). The pharmacology of impulsive behavior in rats: The effects of drugs on response choice with varying delays of reinforcement. Psychopharmacology, 128, 161–170.
Fellows, L. K. (2007). The role of orbitofrontal cortex in decision making: A component process account. In G. Schoenbaum, J. A. Gottfried, E. A. Murray, & S. J. Ramus (Eds.), Linking affect to action: Critical contributions of the orbitofrontal cortex (Annals of the New York Academy of Sciences, Vol. 1121, pp. 421–430). New York: New York Academy of Sciences.
Fellows, L. K., & Farah, M. J. (2005). Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans. Cerebral Cortex, 15, 58–63.
Fiorillo, C. D., Tobler, P. N., & Schultz, W. (2003). Discrete coding of reward probability and uncertainty by dopamine neurons. Science, 299, 1898–1902.
Floresco, S. B. (2007). Dopaminergic regulation of limbic-striatal interplay. Journal of Psychiatry & Neuroscience, 32, 400–411.
Floresco, S. B., & Ghods-Sharifi, S. (2007). Amygdala-prefrontal cortical circuitry regulates effort-based decision making. Cerebral Cortex, 17, 251–260.
Floresco, S. B., Ghods-Sharifi, S., Vexelman, C., & Magyar, O. (2006). Dissociable roles for the nucleus accumbens core and shell in regulating set shifting. Journal of Neuroscience, 26, 2449–2457.
Floresco, S. B., & Magyar, O. (2006). Mesocortical dopamine modulation of executive functions: Beyond working memory. Psychopharmacology, 188, 567–585.
Floresco, S. B., McLaughlin, R. J., & Haluk, D. M. (2008). Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior. Neuroscience, 154, 877–884.
Floresco, S. B., Tse, M. T. L., & Ghods-Sharifi, S. (2008). Dopaminergic and glutamatergic regulation of effort- and delay-based decision making. Neuropsychopharmacology, 33, 1966–1979.
Fu, C. H., Morgan, K., Suckling, J., Williams, S. C., Andrew, C., Vythelingum, G. N., & McGuire, P. K. (2002). A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: Greater anterior cingulate activation with increased task demand. NeuroImage, 17, 871–879.
Garrud, P., Goodall, G., & Mackintosh, N. J. (1981). Overshadowing of a stimulus-reinforcer association by an instrumental response. Quarterly Journal of Experimental Psychology, 33B, 123–135.
Ghods-Sharifi, S., & Floresco, S. B. (2007). Dissociable involvement of nucleus accumbens subregions in effort-based decision making. Society for Neuroscience Abstracts, 741.2.
Ghods-Sharifi, S., St. Onge, J. R., & Floresco, S. B. (2006). Dopaminergic modulation of effort and risk-based decision making. Neuropsychopharmacology, 31, S207.
Hariri, A. R., Brown, S. M., Williamson, D. E., Flory, J. D., de Wit, H., & Manuck, S. B. (2006). Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. Journal of Neuroscience, 26, 13213–13217.
Heerey, E. A., Robinson, B. M., McMahon, R. P., & Gold, J. M. (2007). Delay discounting in schizophrenia. Cognitive Neuropsychiatry, 12, 213–221.
Hsu, M., Bhatt, M., Adolphs, R., Tranel, D., & Camerer, C. F. (2005). Neural systems responding to degrees of uncertainty in human decision-making. Science, 310, 1680–1683.
Hutton, S. B., Murphy, F. C., Joyce, E. M., Rogers, R. D., Cuthbert, I., Barnes, T. R., et al. (2002). Decision making deficits in patients with first-episode and chronic schizophrenia. Schizophrenia Research, 55, 249–257.
Kaminski, B. J., & Ator, N. A. (2001). Behavioral and pharmacological variables affecting risky choice in rats. Journal of the Experimental Analysis of Behavior, 75, 275–297.
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975). Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Research, 94, 507–522.
Kheramin, S., Body, S., Ho, M. Y., Velazquez-Martinez, D. N., Bradshaw, C. M., Szabadi, E., et al. (2004). Effects of orbital prefrontal cortex dopamine depletion on intertemporal choice: A quantitative analysis. Psychopharmacology, 175, 206–214.
Koob, G., Riley, S. T., Smith, S. C., & Robbins, T. W. (1978). Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity and amphetamine anorexia in the rat. Journal of Comparative Physiology & Psychology, 92, 917–927.
Kuhnen, C. M., & Knutson, B. (2005). The neural basis of financial risk taking. Neuron, 47, 763–770.
Lattal, K. A., & Gleeson, S. (1990). Response acquisition with delayed reinforcement. Journal of Experimental Psychology: Animal Behavioral Processes, 16, 27–39.
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., & Robbins, T. (2002). Decision-making processes following damage to the prefrontal cortex. Brain, 125, 624–639.
Marsh, A. A., Blair, K. S., Vythilingam, M., Busis, S., & Blair, R. J. (2007). Response options and expectations of reward in decisionmaking: The differential roles of dorsal and rostral anterior cingulate cortex. NeuroImage, 35, 979–988.
Mazur, J. (1987). An adjusting procedure for studying delayed reinforcement. In M. L. Commons, J. A. Nevin, & H. C. Rachlin (Eds.), Quantitative analyses of behavior: The effect of delay and intervening events on reinforcement value (pp. 55–73). Hillsdale, NJ: Erlbaum.
Mobini, S., Body, S., Ho, M. Y., Bradshaw, C. M., Szabadi, E., Deakin, J. F., & Anderson, I. M. (2002). Effects of lesions of the orbitofrontal cortex on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology, 160, 290–298.
Monterosso, J., Ehrman, R., Napier, K. L., O’Brien, C. P., & Childress, A. R. (2001). Three decision-making tasks in cocaine-dependent patients: Do they measure the same construct? Addiction, 96, 1825–1837.
Must, A., Szabó, Z., Bódi, N., Szász, A., Janka, Z., & Kéri, S. (2006). Sensitivity to reward and punishment and the prefrontal cortex in major depression. Journal of Affective Disorders, 90, 209–215.
Naccache, L., Dehaene, S., Cohen, L., Habert, M. O., Guichart Gomez, E., Galanaud, D., & Willer, J. C. (2005). Effortless control: Executive attention and conscious feeling of mental effort are dissociable. Neuropsychologia, 43, 1318–1328.
Nowend, K. L., Arizzi, M., Carlson, B. B., & Salamone, J. D. (2001). D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses leverpressing for food but leads to compensatory increases in chow consumption. Pharmacology, Biochemistry, & Behavior, 69, 373–382.
O’Doherty, J. P. (2004). Reward representations and reward-related learning in the human brain: Insights from neuroimaging. Current Opinion in Neurobiology, 14, 769–776.
Pagonabarraga, J., García-Sánchez, C., Llebaria, G., Pascual-Sedano, B., Gironell, A., & Kulisevsky, J. (2007). Controlled study of decision-making and cognitive impairment in Parkinson’s disease. Movement Disorders, 22, 1430–1435.
Pais-Vieira, M., Lima, D., & Galhardo, V. (2007). Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats. Neuroscience, 145, 225–231.
Paulus, M. P., & Frank, L. R. (2006). Anterior cingulate activity modulates nonlinear decision weight function of uncertain prospects. NeuroImage, 30, 668–677.
Phelps, E. A., & LeDoux, J. E. (2005). Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron, 20, 175–187.
Pratt, W. E., & Mizumori, S. J. Y. (1998). Characteristics of basolateral amygdala neuronal firing on a spatial memory task involving differential reward. Behavioral Neuroscience, 112, 554–570.
Quickfall, J., & Suchowersky, O. (2007). Pathological gambling associated with dopamine agonist use in restless legs syndrome. Parkinsonism & Related Disorders, 13, 535–536.
Ragozzino, M. E. (2007). The contribution of the medial prefrontal cortex, orbitofrontal cortex, and dorsomedial striatum to behavioral flexibility. In G. Schoenbaum, J. A. Gottfried, E. A. Murray, & S. J. Ramus (Eds.), Linking affect to action: Critical contributions of the orbitofrontal cortex (Annals of the New York Academy of Sciences, Vol. 1121, pp. 421–430). New York: New York Academy of Sciences.
Reep, R. L., Goodwin, G. S., & Corwin, J. V. (1990). Topographic organization in the corticocortical connections of medial agranular cortex in rats. Journal of Comparative Neurology, 294, 262–280.
Reynolds, S. M., & Zahm, D. S. (2005). Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala. Journal of Neuroscience, 25, 11757–11767.
Richards, J. B., Mitchell, S. H., de Wit, H., & Seiden, L. S. (1997). Determination of discount functions in rats with an adjusting-amount procedure. Journal of the Experimental Analysis of Behavior, 67, 353–366.
Robbins, T. W., Roberts, D. C., & Koob, G. (1983). Effects of d-amphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens. Journal of Pharmacology & Experimental Therapeutics, 224, 662–673.
Rogers, R. D., Everitt, B. J., Baldacchino, A., Blackshaw, A. J., Swainson, R., Wynne, K., et al. (1999). Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology, 20, 322–339.
Rogers, R. D., Ramnani, N., Mackay, C., Wilson, J. L., Jezzard, P., Carter, C. S., & Smith, S. M. (2004). Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition. Biological Psychiatry, 15, 594–602.
Roiser, J. P., McLean, A., Ogilvie, A. D., Blackwell, A. D., Bamber, D. J., Goodyer, I., et al. (2005). The subjective and cognitive effects of acute phenylalanine and tyrosine depletion in patients recovered from depression. Neuropsychopharmacology, 30, 775–785.
Rudebeck, P. H., Walton, M. E., Smyth, A. N., Bannerman, D. M., & Rushworth, M. F. (2006). Separate neural pathways process different decision costs. Nature Neuroscience, 9, 1161–1168.
Saddoris, M. P., Gallagher, M., & Schoenbaum, G. (2005). Rapid associative encoding in basolateral amygdala depends on connections with orbitofrontal cortex. Neuron, 46, 321–331.
Salamone, J. D., Correa, M., Farrar, A., & Mingote, S. M. (2007). Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology, 191, 461–482.
Salamone, J. D., Cousins, M. S., & Bucher, S. (1994). Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure. Behavioural Brain Research, 65, 221–229.
Salamone, J. D., Steinpreis, R. E., McCullough, L. D., Smith, P., Grebel, D., & Mahan, K. (1991). Haloperidol and nucleus accumbens dopamine depletion suppress leverpressing for food but increase free food consumption in a novel food choice procedure. Psychopharmacology, 104, 515–521.
Salinas, J. A., Packard, M. G., & McGaugh, J. L. (1993). Amygdala modulates memory for changes in reward magnitude: Reversible posttraining inactivation with lidocaine attenuates the response to a reduction in reward. Behavioural Brain Research, 59, 153–159.
Schoenbaum, G., Chiba, A. A., & Gallagher, M. (1998). Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning. Nature Neuroscience, 2, 155–159.
Schoenbaum, G., Chiba, A. A., & Gallagher, M. (1999). Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. Journal of Neuroscience, 19, 1876–1884.
Schoenbaum, G., Setlow, B., & Ramus, S. J. (2003). A systems approach to orbitofrontal cortex function: Recordings in rat orbitofrontal cortex reveal interactions with different learning systems. Behavioural Brain Research, 146, 19–29.
Schweimer, J., & Hauber, W. (2005). Involvement of the rat anterior cingulate cortex in control of instrumental responses guided by reward expectancy. Learning & Memory, 12, 334–342.
Schweimer, J., & Hauber, W. (2006). Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making. Learning & Memory, 13, 777–782.
Seedat, S., Kesler, S., Niehaus, D. J., & Stein, D. J. (2000). Pathological gambling behavior: Emergence secondary to treatment of Parkinson’s disease with dopaminergic agents. Depression & Anxiety, 11, 185–186.
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989). Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. Journal of Comparative Neurology, 290, 213–242.
Shurman, B., Horan, W. P., & Nuechterlein, K. H. (2005). Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. Schizophrenia Research, 27, 215–224.
Swainson, R., Rogers, R. D., Sahakian, B. J., Summers, B. A., Polkey, C. E., & Robbins, T. W. (2000). Probabilistic learning and reversal deficits in patients with Parkinson’s disease or frontal or temporal lobe lesions: Possible adverse effects of dopaminergic medication. Neuropsychologia, 38, 596–612.
Tom, S. M., Fox, C. R., Trepel, C., & Poldrack, R. A. (2007). The neural basis of loss aversion in decision-making under risk. Science, 315, 515–518.
van Gaalen, M. M., van Koten, R., Schoffelmeer, A. N. M., & Vanderschuren, L. J. M. J. (2006). Critical involvement of dopaminergic neurotransmission in impulsive decision making. Biological Psychiatry, 60, 66–73.
Voon, V., Hassan, K., Zurowski, M., Duff-Canning, S., de Souza, M., Fox, S., et al. (2006). Prospective prevalence of pathologic gambling and medication association in Parkinson disease. Neurology, 66, 1750–1752.
Wade, T. R., de Wit, H., & Richards, J. B. (2000). Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology, 150, 90–101.
Walton, M. E., Bannerman, D. M., Alterescu, K., & Rushworth, M. F. (2003). Functional specialization within medial frontal cortex of the anterior cingulate for evaluating effort-related decisions. Journal of Neuroscience, 23, 6475–6479.
Walton, M. E., Bannerman, D. M., & Rushworth, M. F. (2002). The role of rat medial frontal cortex in effort-based decision making. Journal of Neuroscience, 22, 10996–11003.
Weller, J. A., Levin, I. P., Shiv, B., & Bechara, A. (2007). Neural correlates of adaptive decision making for risky gains and losses. Psychological Science, 18, 958–964.
Winstanley, C. A., Theobald, D. E., Cardinal, R. N., & Robbins, T. W. (2004). Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. Journal of Neuroscience, 24, 4718–4722.
Winstanley, C. A., Theobald, D. E., Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2006). Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice. Cerebral Cortex, 16, 106–114.
Winstanley, C. A., Theobald, D. E., Dalley, J. W., & Robbins, T. W. (2003). Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice in rats. Psychopharmacology, 170, 320–331.
Winstanley, C. A., Theobald, D. E., Dalley, J. W., & Robbins, T. W. (2005). Interactions between serotonin and dopamine in the control of impulsive choice in rats: Therapeutic implications for impulse control disorders. Neuropsychopharmacology, 30, 669–682.
Wise, R. A., & Rompre, P. P. (1989). Brain dopamine and reward. Annual Review of Psychology, 40, 191–225.
Zeeb, F. D., Floresco, S. B., & Winstanley, C. A. (2007). What makes it worth the wait? Investigating the effects of orbitofrontal cortex inactivation on impulsive choice. Society for Neuroscience Abstracts, 741.3.
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Some of the studies reviewed in this article were supported by grants from the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada, and Parkinson’s Society Canada. J.R.S.O. is the recipient of a Michael Smith Graduate Student Fellowship, and S.B.F. is a CIHR New Investigator and a Michael Smith Scholar.
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Floresco, S.B., Onge, J.R.S., Ghods-Sharifi, S. et al. Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making. Cognitive, Affective, & Behavioral Neuroscience 8, 375–389 (2008). https://doi.org/10.3758/CABN.8.4.375
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DOI: https://doi.org/10.3758/CABN.8.4.375