Abstract
We investigated the neural bases for false memory with fMRI by examining neural activity during retrieval processes that yielded true or false memories. We used a reality monitoring paradigm in which participants saw or imagined pictures of concrete objects. (A subsequent misinformation task was also used to increase false memory rates.) At test, fMRI data were collected as the participants determined whether they had seen or had only imagined the object at study. True memories were of seen pictures accurately endorsed as seen, and for false memories were of imagined pictures falsely endorsed as seen. Three distinct patterns of activity were observed: Left frontal and parietal activity was not different for true and for false memories, whereas activity was greater for true than for false memories in occipital visual regions and posterior portions of the parahippocampal gyrus, and activity was greater for false than for true memories in right anterior cingulate gyrus. Possible interpretations are discussed.
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Allan, K., Wilding, E. L., & Rugg, M. D. (1998). Electrophysiological evidence for dissociable processes contributing to recollection. Acta Psychologica, 98, 231–252.
Botvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S., & Cohen, J. D. (1999). Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature, 402, 179–181.
Buckner, R. L., Koutstaal, W., Schacter, D. L., Dale, A. M., Rotte, M., & Rosen, B. R. (1998). Functional-anatomic study of episodic retrieval: II. Selective averaging of event-related fMRI trials to test the retrieval success hypothesis. NeuroImage, 7, 163–175.
Buckner, R. L., Koutstaal, W., Schacter, D. L., Wagner, A. D., & Rosen, B. R. (1998). Functional-anatomic study of episodic retrieval using fMRI: I. Retrieval effort versus retrieval success. NeuroImage, 7, 151–162.
Cabeza, R., & Nyberg, L. (2000). Imaging cognition II: An empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience, 12, 1–47.
Cabeza, R., Rao, S. M., Wagner, A. D., Mayer, A. R., & Schacter, D. L. (2001). Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study of veridical and illusory recognition memory. Proceedings of the National Academy of Sciences, 98, 4805–4810.
Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M.M., Noll, D., & Cohen, J. D. (1998). Anterior cingulate cortex, error detection, and the online monitoring of performance. Science, 280, 747–749.
Cox, R. W. (1996). AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Computational Biochemical Research, 29, 162–173. Available at http://afni.nimh.nih. gov.
Deese, J. (1959). On the prediction of occurrence of particular verbal intrusions in immediate recall. Journal of Experimental Psychology, 58, 17–22.
Fabiani, M., Stadler, M. A., & Wessels, P. M. (2000). True but not false memories produce a sensory signature in human lateralized brain potentials. Journal of Cognitive Neuroscience, 12, 941–949.
Farah, M. J. (1989). The neural basis of mental imagery. Trends in Neurosciences, 12, 395–399.
Gonsalves, B., & Paller, K. A. (2000). Neural events that underlie remembering something that never happened. Nature Neuroscience, 3, 1316–1321.
Henson, R. N. A., Rugg, M. D., Shallice, T., Josephs, O., & Dolan, R. J. (1999). Recollection and familiarity in recognition memory: An event-related functional magnetic resonance imaging study. Journal of Neuroscience, 19, 3962–3972.
Insausti, R., Juottonen, K., Soininen, H., Insausti, A. M., Partanen, K., Vainio, P., Laakso, M. P ., & Pitkanen, A. (1998). MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. American Journal of Neuroradiology, 19, 659–671.
Johnson, M. K. (1997). Source monitoring and memory distortion. Philosophical Transactions of the Royal Society of London: Series B, 352, 1733–1745.
Johnson, M. K., Hashtroudi, S., & Lindsay, D. S. (1993). Source monitoring. Psychological Bulletin, 114, 3–28.
Johnson, M. K., & Raye, C. L. (1981). Reality monitoring. Psychological Review, 88, 67–85.
Johnson, M. K., & Raye, C. L. (2000). Cognitive and brain mechanisms of false memories and beliefs. In D. L. Schacter & E. Scarry (Eds.), Memory and belief (pp. 36–86). Cambridge, MA: Harvard University Press.
Johnson, M. K., Raye, C. L., Wang, A. Y., & Taylor, T. H. (1979). Fact and fantasy: The roles of accuracy and variability in confusing imaginations with perceptual experiences. Journal of Experimental Psychology: Human Learning & Memory, 5, 229–240.
Johnson, M. K., Taylor, T. H., & Raye, C. L. (1977). Fact and fantasy: The effects of internally generated events on the apparent frequency of externally generated events. Memory & Cognition, 5, 116–122.
Kosslyn, S. M., Pascual-Leone, A., Felician, O., Camposano, S., Keenan, J. P., Thompson, W. L., Ganis, G., Sukel, K. E., & Alpert, N. M. (1999). The role of Area 17 in visual imagery: Convergent evidence from PET and rTMS. Science, 284, 167–170.
Loftus, E. F., & Loftus, G. R. (1980). On the permanence of stored information in the human brain. American Psychologist, 35, 409–420.
Loftus, E. F., Miller, D. G., & Burns, H. J. (1978). Semantic integration of verbal information into a visual memory. Journal of Experimental Psychology: Human Learning & Memory, 4, 19–31.
Loftus, E. F., & Palmer, J. C. (1974). Reconstruction of automobile destruction: An example of the interaction between language and memory. Journal of Verbal Learning & Verbal Behavior, 13, 585–589.
Loftus, E. F., & Pickrell, J. E. (1995). The formation of false memories. Psychiatric Annals, 25, 720–725.
McCloskey, M., & Zaragoza, M. (1985). Misleading postevent information and memory for events: Arguments and evidence against memory impairment hypotheses. Journal of Experimental Psychology: General, 114, 1–16.
Miller, A. R., Baratta, C., Wynveen, C., & Rosenfeld, J. P. (2001). P300 latency, but not amplitude or topography, distinguishes between true and false recognition. Journal of Experimental Psychology: Learning, Memory, & Cognition, 27, 354–361.
Milner, B., Squire, L. R., & Kandel, E. R. (1998). Cognitive neuroscience and the study of memory. Neuron, 20, 445–468.
Nessler, D., Mecklinger, A., & Penney, T. B. (2001). Event related brain potentials and illusory memories: The effects of differential encoding. Cognitive Brain Research, 10, 283–301.
Pruessner, J. C., Kohler, S., Crane, J., Pruessner, M., Lord, C., Byrne, A., Kabani, N., Collins, D. L., & Evans, A. C. (2002). Volumetry of temporopolar, perirhinal, entorhinal, and parahippocampal cortex from high-resolution MR images: Considering the variability of the collateral sulcus. Cerebral Cortex, 12, 1342–1353.
Ranganath, C., Johnson, M. K., & D’Esposito, M. (2000). Left anterior prefrontal activation increases with demands to recall specific perceptual information. Journal of Neuroscience, 20, 1–5.
Roediger, H. L., III (1996). Memory illusions. Journal of Memory & Language, 35, 76–100.
Roediger, H. L., III, & McDermott, K. B. (1995). Creating false memories: Remembering words not presented in lists. Journal of Experimental Psychology: Learning, Memory, & Cognition, 21, 803–814.
Rugg, M. D., Fletcher, P. C., Frith, C. D., Frackowiak, R. S. J., & Dolan, R. J. (1996). Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval. Brain, 1919, 2073–2083.
Schacter, D. L. (1999). The seven sins of memory. American Psychologist, 54, 182–203.
Schacter, D. L., Buckner, R. L., Koutstaal, W., Dale, A. M., & Rosen, B. R. (1997). Late onset of anterior prefrontal activity during true and false recognition: An event-related fMRI study. NeuroImage, 6, 259–269.
Schacter, D. L., Norman, K. A., & Koutstaal, W. (1998). The cognitive neuroscience of constructive memory. Annual Review of Psychology, 49, 289–318.
Schacter, D. L., Reiman, E., Curran, T., Yun, L. S., Bandy, D., Mc-Dermott, K. B., & Roediger, H. L., III (1996). Neuroanatomical correlates of veridical and illusory recognition memory: Evidence from positron emission tomography. Neuron, 17, 267–274.
Stark, C. E. L., & Okado, Y. (2003). Making memories without trying: Medial temporal lobe activity associated with incidental memory formation during recognition. Journal of Neuroscience, 23, 6748–6753.
Stark, C. E. L., & Squire, L. R. (2000). Functional magnetic resonance imaging (fMRI) activity in the hippocampal region during recognition memory. Journal of Neuroscience, 20, 7776–7781.
Stark, C. E. L., & Squire, L. R. (2001a). Simple and associative recognition memory in the hippocampal region. Learning & Memory, 8, 190–197.
Stark, C. E. L., & Squire, L. R. (2001b). When zero is not zero: The problem of ambiguous baseline conditions in fMRI. Proceedings of the National Academy of Sciences, 98, 12760–12766.
Suzuki, W. A., & Eichenbaum, H. (2000). The neurophysiology of memory. Annals of the New York Academy of Sciences, 911, 175–191.
Talairach, J., & Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain. New York: Thieme.
Tulving, E. (1985). Memory and consciousness. Canadian Psychology, 26, 1–12.
Wagner, A. D., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. E. (1998). Prefrontal cortex and recognition memory: Functional-MRI evidence for context-dependent retrieval processes. Brain, 121, 1985–2002.
Ward, D. (2000). Deconvolution analysis of FMRI time series data. Available at http://afni.nimh.nih.gov/afni/docpdf/3dDeconvolve. pdf.).
Wheeler, M. E., & Buckner, R. L. (2003). Functional dissociation among components of remembering: Control, perceived oldness, and content. Journal of Neuroscience, 23, 3869–3880.
Wheeler, M. E., Petersen, S. E., & Buckner, R. L. (2000). Memory’s echo: Vivid remembering reactivates sensory-specific cortex. Proceedings of the National Academy of Sciences, 97, 11125–11129.
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The research presented in this article was funded by Johns Hopkins University and NSF Grant BCS-0236431.
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Okado, Y., Stark, C. Neural processing associated with true and false memory retrieval. Cognitive, Affective, & Behavioral Neuroscience 3, 323–334 (2003). https://doi.org/10.3758/CABN.3.4.323
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DOI: https://doi.org/10.3758/CABN.3.4.323