The Relationship of Dietary Pattern and Genetic Risk Score with the Incidence of Dyslipidemia: 14-Year Follow-Up Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Methods
2.2.1. Nutritional Assessment and Dietary Pattern Analysis
2.2.2. Definition of Dyslipidemia
2.2.3. Measurement of Covariates
2.2.4. Genotyping and GRS
2.2.5. Statistical Analysis
3. Results
3.1. Dietary Pattern Analysis
3.2. Characteristics of Subjects by Each Dietary Pattern
3.3. Analysis of Dyslipidemia Risk by Dietary Pattern
3.4. Interaction of Dietary Pattern with GRS on Dyslipidemia
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Food Groups | Meat, Fish and Vegetables | Bread and Noodle | Whole Grain and Soybean Products |
---|---|---|---|
White rice | −0.83 | ||
Rice with grains | 0.85 | ||
Ramen | 0.40 | −0.21 | |
Noodles | 0.39 | ||
Other noodles | 0.61 | ||
Dumplings | 0.61 | ||
Rice cake | 0.57 | ||
Bread | 0.66 | ||
Pizza/Hamburger | 0.37 | ||
Flake | 0.32 | ||
Cakes | 0.36 | ||
Snacks/Sweets | 0.24 | ||
Butter/Margarine | 0.31 | ||
Potatoes | 0.31 | 0.45 | |
Soybeans and beans products | 0.24 | 0.36 | |
Nuts | 0.15 | 0.24 | |
Kimchi | 0.25 | ||
Green-yellow vegetables | 0.61 | ||
Root vegetables | 0.62 | ||
Pickle/Salt-fermented fish | 0.37 | ||
Mushrooms | 0.52 | ||
Fruits | 0.48 | ||
Meats | 0.64 | ||
Eggs | 0.37 | ||
White fish | 0.62 | ||
external blue colored fish | 0.59 | ||
Anchovy | 0.39 | 0.24 | |
Cuttlefish/Octopus | 0.52 | ||
Fish cake | 0.39 | ||
Shellfish | 0.55 | ||
Seaweeds | 0.44 | 0.21 | |
Milk | 0.23 | ||
Dairy products | 0.21 | 0.24 | |
Carbonated drinks | |||
Coffee | |||
Green tea and other drinks | 0.23 | ||
Variance explained | 4.21 | 2.87 | 2.03 |
Meat, Fish and Vegetables | Bread and Noodle | Whole Grain and Soybean Products | ||||
---|---|---|---|---|---|---|
Q1 (n = 2426) | Q4 (n = 2426) | Q1 (n = 2426) | Q4 (n = 2426) | Q1 (n = 2426) | Q4 (n = 2426) | |
Mean ± SD | Q1 | Q4 | Q1 | Q4 | Q1 | Q4 |
Age | 54.9 ± 0.2 | 50.7 ± 0.2 *** | 55.2 ± 0.2 | 49.7 ± 0.2 *** | 51.3 ± 0.2 | 53.7 ± 0.2 *** |
BMI | 24.4 ± 0.1 | 24.8 ± 0.1 *** | 24.6 ± 0.1 | 24.6 ± 0.1 | 24.4 ± 0.1 | 24.7 ± 0.1 *** |
Energy | 1585.4 ± 11.5 | 2472.9 ± 17.4 *** | 1720.8 ± 13.4 | 2412.4 ± 16.6 *** | 1918.4 ± 15.0 | 2050.3 ± 13.6 *** |
Total cholesterol | 190.7 ± 0.7 | 192.0 ± 0.7 | 190.0 ± 0.7 | 192.7 ± 0.7 * | 191.1 ± 0.7 | 193.5 ± 0.8 ** |
HDL cholesterol | 44.6 ± 0.2 | 44.7 ± 0.2 | 44.2 ± 0.2 | 45.1 ± 0.2 ** | 44.6 ± 0.2 | 45.1 ± 0.2 |
Triglyceride | 162.5 ± 2.1 | 162.7 ± 2.2 | 165.1 ± 2.0 | 163.4 ± 2.3 | 167.2 ± 2.2 | 158.1 ± 2.2 * |
Male (%) | 43.2 | 49.5 *** | 40.5 | 51.4 *** | 62.9 | 34.0 *** |
Area (%) | ||||||
Rural | 64.5 | 45.3 *** | 62.2 | 39.9 *** | 58.8 | 40.0 *** |
Urban | 35.5 | 54.7 | 37.8 | 60.1 | 41.2 | 60.0 |
Education (%) | ||||||
Elementary school | 48.7 | 25.3 *** | 49.3 | 21.3 *** | 32.9 | 35.2 *** |
Middle school | 21.3 | 23.2 | 22.9 | 20.8 | 24.0 | 21.6 |
High school | 22.2 | 34.7 | 20.9 | 37.7 | 30.5 | 29.2 |
College or higher degree | 7.8 | 16.8 | 6.9 | 20.3 | 12.6 | 14.0 |
Income (%) | ||||||
<1,500,000 won | 66.5 | 41.7 *** | 64.7 | 40.1*** | 54.0 | 49.4 *** |
≥1,500,000 won | 33.5 | 58.3 | 35.3 | 59.9 | 46.0 | 50.6 |
Current drinking (%) | ||||||
Yes | 40.9 | 51.0 *** | 41.9 | 51.5 *** | 56.1 | 38.5 *** |
Current smoking (%) | ||||||
Yes | 17.2 | 18.8 | 14.8 | 20.2 *** | 21.1 | 16.1 *** |
Regular exercise (%) | ||||||
Yes | 21.0 | 33.9 *** | 22.3 | 33.2 *** | 21.2 | 35.2 *** |
No of Total | No of Cases | Model 1 | Model 2 | ||||
---|---|---|---|---|---|---|---|
HR 95% CI | HR 95% CI | ||||||
Hypercholesterolemia | |||||||
Meat, fish and vegetables | Q1 | 1967 | 530 | 1.00 | 1.00 | ||
Q2 | 1973 | 533 | 1.02 | 0.90–1.15 | 0.92 | 0.81–1.04 | |
Q3 | 1977 | 548 | 1.06 | 0.94–1.19 | 0.95 | 0.83–1.08 | |
Q4 | 1983 | 517 | 1.02 | 0.90–1.15 | 0.91 | 0.79–1.05 | |
p for trend | 0.7574 | 0.3079 | |||||
Bread and noodle | Q1 | 1992 | 520 | 1.00 | 1.00 | ||
Q2 | 1986 | 538 | 1.05 | 0.93–1.18 | 1.03 | 0.91–1.17 | |
Q3 | 1968 | 525 | 1.03 | 0.91–1.17 | 0.98 | 0.86–1.11 | |
Q4 | 1954 | 545 | 1.11 | 0.98–1.26 | 1.05 | 0.92–1.20 | |
p for trend | 0.1071 | 0.556 | |||||
Whole grain and soybean products | Q1 | 1985 | 506 | 1.00 | 1.00 | ||
Q2 | 1986 | 532 | 0.98 | 0.87–1.11 | 0.93 | 0.82–1.06 | |
Q3 | 2000 | 545 | 0.94 | 0.83–1.06 | 0.83 | 0.73–0.94 | |
Q4 | 1929 | 545 | 0.94 | 0.83–1.06 | 0.82 | 0.72–0.93 | |
p for trend | 0.2246 | 0.0006 | |||||
Hypertriglyceridemia | |||||||
Meat, fish and vegetables | Q1 | 1691 | 532 | 1.00 | 1.00 | ||
Q2 | 1672 | 521 | 1.00 | 0.89–1.13 | 0.99 | 0.87–1.12 | |
Q3 | 1695 | 556 | 1.05 | 0.93–1.18 | 1.03 | 0.90–1.16 | |
Q4 | 1678 | 514 | 1.01 | 0.89–1.14 | 1.00 | 0.87–1.16 | |
p for trend | 0.806 | 0.8508 | |||||
Bread and noodle | Q1 | 1661 | 543 | 1.00 | 1.00 | ||
Q2 | 1704 | 564 | 0.97 | 0.86–1.09 | 0.96 | 0.86–1.09 | |
Q3 | 1724 | 522 | 0.87 | 0.77–0.99 | 0.87 | 0.77–0.99 | |
Q4 | 1647 | 494 | 0.86 | 0.76–0.98 | 0.87 | 0.76–1.00 | |
p for trend | 0.0126 | 0.0363 | |||||
Whole grain and soybean products | Q1 | 1653 | 558 | 1.00 | 1.00 | ||
Q2 | 1670 | 503 | 0.87 | 0.77–0.98 | 0.87 | 0.77–0.98 | |
Q3 | 1681 | 524 | 0.88 | 0.78–0.99 | 0.85 | 0.75–0.97 | |
Q4 | 1732 | 538 | 0.87 | 0.77–0.98 | 0.85 | 0.75–0.97 | |
p for trend | 0.0613 | 0.0344 |
SNP Name | Chromosome | Position | Gene | P-HWE | MAF(ASN) | Ref Allele | Alt Allele | Risk Allele | p-Value | Source |
---|---|---|---|---|---|---|---|---|---|---|
rs10889353 | 1 | 63118196 | ANGPTL3 | 0.2673 | 0.173 | A | C | C | 3.00 × 10−7 | PMID: 19060906 |
rs7557067 | 2 | 21208211 | APOB | 0.4536 | 0.272 | A | G | G | 9.00 × 10−12 | PMID: 19060906 |
rs780092 | 2 | 27743154 | GCKR | 0.5279 | 0.326 | A | G | A | 2.00 × 10−9 | PMID: 23105936 |
rs1919127 | 2 | 27801493 | C2orf16 | 0.4481 | 0.474 | T | C | T | 3.00 × 10−11 | PMID: 31910446 |
rs2954029 | 8 | 126490972 | TRIB1 | 0.0774 | 0.442 | A | T | A | 3.00 × 10−19 | PMID: 19060906 |
rs174547 | 11 | 61570783 | FADS1-FADS2-FADS3 | 0.0739 | 0.322 | T | C | C | 2.00 × 10−14 | PMID: 19060906 |
rs2266788 | 11 | 116660686 | APOA5 | 0.5322 | 0.218 | G | A | A | 2.00 × 10−16 | PMID: 31910446 |
GRS Categories | Whole Grain and Soybean Products Dietary Pattern Score | Model 1 | Model 2 | ||||
---|---|---|---|---|---|---|---|
HR | 95% CI | p | HR | 95% CI | p | ||
Hypercholesterolemia | |||||||
GRS Tertile 1 | Q1 | 1.00 | 1.00 | ||||
Q2 | 1.20 | 0.92–1.56 | 0.1857 | 1.12 | 0.86–1.48 | 0.3999 | |
Q3 | 1.22 | 0.94–1.58 | 0.1365 | 1.08 | 0.83–1.42 | 0.5537 | |
Q4 | 1.11 | 0.85–1.44 | 0.4559 | 1.00 | 0.76–1.32 | 0.9824 | |
p for trend | 0.583 | 0.8119 | |||||
GRS Tertile 2 | Q1 | 1.00 | 1.00 | ||||
Q2 | 1.13 | 0.92–1.40 | 0.2527 | 1.05 | 0.85–1.30 | 0.6688 | |
Q3 | 1.07 | 0.86–1.32 | 0.5425 | 0.88 | 0.71–1.09 | 0.2407 | |
Q4 | 1.07 | 0.86–1.33 | 0.558 | 0.85 | 0.68–1.07 | 0.1722 | |
p for trend | 0.8734 | 0.0433 | |||||
GRS Tertile 3 | Q1 | 1.00 | 1.00 | ||||
Q2 | 0.84 | 0.68–1.04 | 0.0995 | 0.81 | 0.65–1.01 | 0.0577 | |
Q3 | 0.74 | 0.59–0.92 | 0.0066 | 0.68 | 0.55–0.86 | 0.0009 | |
Q4 | 0.82 | 0.66–1.02 | 0.0707 | 0.74 | 0.59–0.93 | 0.011 | |
p for trend | 0.053 | 0.0064 | |||||
pinteraction = 0.0815 | |||||||
Hypertriglyceridemia | |||||||
GRS Tertile 1 | Q1 | 1.00 | 1.00 | ||||
Q2 | 0.99 | 0.77–1.28 | 0.95 | 1.04 | 0.80–1.34 | 1.232 | |
Q3 | 1.06 | 0.83–1.35 | 0.66 | 1.04 | 0.81–1.33 | 1.175 | |
Q4 | 0.92 | 0.71–1.17 | 0.482 | 0.92 | 0.71–1.20 | 1.251 | |
p for trend | 0.6411 | 0.5676 | |||||
GRS Tertile 2 | Q1 | 1.00 | 1.00 | ||||
Q2 | 0.90 | 0.72–1.11 | 0.3236 | 0.88 | 0.71–1.10 | 0.2547 | |
Q3 | 0.92 | 0.74–1.13 | 0.415 | 0.87 | 0.70–1.08 | 0.1976 | |
Q4 | 1.01 | 0.82–1.24 | 0.9506 | 0.97 | 0.77–1.21 | 0.7566 | |
p for trend | 0.788 | 0.8376 | |||||
GRS Tertile 3 | Q1 | 1.00 | 1.00 | ||||
Q2 | 0.84 | 0.68–1.05 | 0.1217 | 0.87 | 0.70–1.08 | 0.2104 | |
Q3 | 0.80 | 0.64–1.00 | 0.0535 | 0.81 | 0.64–1.02 | 0.0725 | |
Q4 | 0.83 | 0.67–1.04 | 0.0992 | 0.87 | 0.69–1.10 | 0.2556 | |
p for trend | 0.1299 | 0.2514 | |||||
pinteraction = 0.5023 |
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Park, S.-J.; Kim, M.-S.; Choi, S.-W.; Lee, H.-J. The Relationship of Dietary Pattern and Genetic Risk Score with the Incidence of Dyslipidemia: 14-Year Follow-Up Cohort Study. Nutrients 2020, 12, 3840. https://doi.org/10.3390/nu12123840
Park S-J, Kim M-S, Choi S-W, Lee H-J. The Relationship of Dietary Pattern and Genetic Risk Score with the Incidence of Dyslipidemia: 14-Year Follow-Up Cohort Study. Nutrients. 2020; 12(12):3840. https://doi.org/10.3390/nu12123840
Chicago/Turabian StylePark, Seon-Joo, Myung-Sunny Kim, Sang-Woon Choi, and Hae-Jeung Lee. 2020. "The Relationship of Dietary Pattern and Genetic Risk Score with the Incidence of Dyslipidemia: 14-Year Follow-Up Cohort Study" Nutrients 12, no. 12: 3840. https://doi.org/10.3390/nu12123840