Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Yong Ku Kim Department of Psychiatry, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Sang Hyun Kim Department of Microbiology, College of Medicine, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea; Institute for Viral Diseases, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

So-Hyun Choi YongIn Mental Hospital, 4 Sanghari, Kusungmyun, Yongln-Kun, Kyungki-Do, 449-910, Korea, Korea

Young-Hoon Ko Department of Psychiatry, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Leen Kim Department of Psychiatry, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Min Soo Lee Department of Psychiatry, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Kwang Yoon Suh Department of Psychiatry, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Dong-Il Kwak Department of Psychiatry, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Ki-Joon Song Department of Microbiology, College of Medicine, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea; Institute for Viral Diseases, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Yong Ju Lee Department of Microbiology, College of Medicine, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea; Institute for Viral Diseases, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

Richard Yanagihara Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, 96816, USA

Jin-Won Song Department of Microbiology, College of Medicine, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea; Institute for Viral Diseases, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-705, Korea

show all

Abstract

RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein-encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase chain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Information for

Open access

Opportunities

Help and information

Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature