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Estimation of the evolutionary stability of the Influenza A virus: Prediction of variable regions in the domain structure of the M1 protein

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Abstract

Influenza virus is a human pathogen that is responsible for several pandemics with high death rates. Two programs were written for the statistical analysis of the coding regions of genes from extensive samples of Influenza A virus. While inner viral proteins appeared to be evolutionarily stable, surface antigens and the NS1 nonstructural protein are highly variable. Using programs to predict the evolutionarily variable regions inside the M1 protein sequence it was shown that the N-domain is the most conserved domain while the M- and C-domains are the most variable. In addition, the C-domain was shown to be the most unfolded one, according to prediction by the DISOPRED algorithm and, thus, possesses the most structural plasticity.

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Authors and Affiliations

  1. Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia

    M. A. Kuznetsova, U. A. Pekov, A. L. Ksenofontov, L. V. Kordyukova & V. L. Drutsa

  2. Belozersky Institute of Physico-Chemical Biology, Moscow, Russia

    M. A. Kuznetsova, U. A. Pekov, A. L. Ksenofontov, L. V. Kordyukova & V. L. Drutsa

Authors
  1. M. A. Kuznetsova
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  2. U. A. Pekov
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  3. A. L. Ksenofontov
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  4. L. V. Kordyukova
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  5. V. L. Drutsa
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Corresponding author

Correspondence to M. A. Kuznetsova.

Additional information

Original Russian Text © M.A. Kuznetsova, U.A. Pekov, A.L. Ksenofontov, L.V. Kordyukova, V.L. Drutsa, 2010, published in Vestnik Moskovskogo Universiteta. Biologiya, 2010, No. 4, pp. 104–107.

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Kuznetsova, M.A., Pekov, U.A., Ksenofontov, A.L. et al. Estimation of the evolutionary stability of the Influenza A virus: Prediction of variable regions in the domain structure of the M1 protein. Moscow Univ. Biol.Sci. Bull. 65, 221–223 (2010). https://doi.org/10.3103/S0096392510040280

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  • DOI: https://doi.org/10.3103/S0096392510040280

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