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Regenerative Medicine

Anti-Müllerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation

    Raffaella Fabbri

    *Author for correspondence:

    E-mail Address: raffaella.fabbri@unibo.it

    Department of Medical & Surgical Sciences (DIMEC), Gynecology & Pathophysiology of Human Reproduction Unit, University of Bologna, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    ,
    Maria Macciocca

    Department of Medical & Surgical Sciences (DIMEC), Gynecology & Pathophysiology of Human Reproduction Unit, University of Bologna, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    ,
    Cristina Melotti

    Central Laboratory, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    ,
    Gianandrea Pasquinelli

    Department of Experimental, Diagnostic & Specialty Medicine (DIMES), Clinical Pathology, University of Bologna, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    ,
    Rossella Vicenti

    Department of Medical & Surgical Sciences (DIMEC), Gynecology & Pathophysiology of Human Reproduction Unit, University of Bologna, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    ,
    Maria Letizia Bacchi Reggiani

    Department of Experimental, Diagnostic & Specialty Medicine (DIMES), Cardiology, University of Bologna, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    ,
    Daniela Terribile

    Department of Surgery, Breast Unit, Catholic University, Rome, Italy

     & 
    Stefano Venturoli

    Department of Medical & Surgical Sciences (DIMEC), Gynecology & Pathophysiology of Human Reproduction Unit, University of Bologna, Sant’Orsola-Malpighi Hospital, Bologna, Italy

    Published Online:https://doi.org/10.2217/fon.14.76

    ABSTRACT: 

    Aim: To evaluate if anti-Müllerian hormone (AMH) is a reliable marker of ovarian reserve in young women undergoing ovarian tissue cryopreservation. Patients & methods: Relationships of serum AMH levels with primordial follicle density, age and reproductive hormones were investigated using the Pearson or Spearman correlation coefficient in 86 women with cancer (12–38 years) undergoing ovarian tissue cryopreservation. AMH variations through the menstrual cycle were assessed by the Kruskal–Wallis test. p < 0.05 was accepted as significant. Results: AMH positively correlated with primordial follicle density (p = 0.03), showed great interindividual variability at all ages and negatively correlated with estradiol (p = 0.007) in the early follicular phase. AMH did not vary across the menstrual cycle (p = 0.415). Conclusion: AMH appears a valid ovarian reserve marker in young cancer women.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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