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Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity

    Jamil N Al-Swiahb*

    Department of Otolaryngology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Song Hsiang, Kaohsiung, 833, Taiwan

    *These authors contributed to this work equally and are co-first authors.

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    ,
    Chang-Han Chen*

    Department of Otolaryngology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Song Hsiang, Kaohsiung, 833, Taiwan

    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Kaohsiung, Taiwan

    *These authors contributed to this work equally and are co-first authors.

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    ,
    Hui-Ching Chuang

    Department of Otolaryngology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Song Hsiang, Kaohsiung, 833, Taiwan

    ,
    Fu-Min Fang

    Department of Radiation Oncology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan

    ,
    Hsin-Ting Tasi

    Department of Otolaryngology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Song Hsiang, Kaohsiung, 833, Taiwan

    &
    Published Online:https://doi.org/10.2217/fon.10.35

    Squamous cell carcinoma of the oral cavity (OCSCC) is the most frequently observed form of head-and-neck cancer in Southeast Asia and is the sixth most common cancer worldwide. Most cases of this preventable disease are caused by alcohol consumption, smoking and betel nut chewing. The survival rates of patients with advanced OCSCC have not increased significantly in recent years. While treatments for OCSCC are similar worldwide, survival rates differ by geographical area. The various genetic profiles and individual genetic susceptibility for carcinogens may account for this discrepancy. In some respects, molecular alteration or accumulation affects tumor progression and the clinical outcomes among patients with OCSCC. Clarifying the tumor behavior of oral cancer, with regard to pathological features or molecular aspects, could help clinicians to judge, tailor and adopt more effective therapeutic strategies to treat oral cancer.

    Papers of special note have been highlighted as: ▪ of interest

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