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Interaction of 22 risk SNPs with Helicobacter pylori infection and risk of gastric cardia adenocarcinoma

**Author for correspondence:

Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, PR China

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Jian Xue Yang

Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, PR China

Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, PR China

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Xin Min Li

Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, PR China

Department of Pathology, Women & Infants Hospital of Zhengzhou, Zhengzhou, Henan 450012, PR China

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Xue Ke Zhao

Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, PR China

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Peng Yuan Zheng

^***Author for correspondence:

E-mail Address: medp7123@126.com

Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, PR China

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Li Dong Wang

*Author for correspondence:

E-mail Address: ldwang2007@outlook.com

https://orcid.org/0000-0001-8023-1949

Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, PR China

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Published Online:25 Oct 2019https://doi.org/10.2217/fon-2019-0319

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Abstract

Aim: To determine the prevalence of Helicobacter pylori infection and correlation between H. pylori infection and single nucleotide polymorphism (SNPs) identified in gastric cardia adenocarcinoma (GCA) patients. Methods: A case control study was performed. 22 risks of GCA-related SNPs were identified by genotyping assay and the relationship between susceptibility loci for GCA and H. pylori infection was further analyzed. Results: Helicobacter pylori infection was associated with GCA significantly (odds ratio: 1.40; 95% CI: 1.29–1.53 p < 0.01). Five GCA risk SNPs had their genotypes significantly different between H. pylori positive patients and H. pylori negative patients. Conclusion: The interaction between SNPs susceptibility loci and H. pylori infection is associated with an increased risk of GCA.

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Vol. 15, No. 31

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History

Received 4 June 2019

Accepted 20 August 2019

Published online 25 October 2019

Published in print November 2019

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Keywords

Financial & competing interests disclosure

This project was funded by 863 HighTech Key Projects (2012AA02A503, 2012AA02A209 and 2012AA02A201) and National Natural Science Foundations (30971133, 81071783). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The study was reviewed and approved by the Ethics committee of Zhengzhou University (no.16047) and it was conducted in accordance with the Declaration of Helsinki. All samples were anonymized before analysis was performed, to guarantee the protection of privacy.

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