We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Virological surveillance of human respiratory syncytial virus A and B at a tertiary hospital in Catalonia (Spain) during five consecutive seasons (2013–2018)

    Laura Gimferrer

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Jorgina Vila

    Paediatric Hospitalisation Unit, Department of Paediatrics, Hospital Universitari Maternoinfantil Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Maria Piñana

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Cristina Andrés

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    José A Rodrigo-Pendás

    Preventive Medicine & Epidemiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Paula Peremiquel-Trillas

    Preventive Medicine & Epidemiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    María G Codina

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    María del C Martín

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Juliana Esperalba

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Francisco Fuentes

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Susana Rubio

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Magda Campins-Martí

    Preventive Medicine & Epidemiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    ,
    Tomàs Pumarola

    *Author for correspondence:

    E-mail Address: virusrespiratoris@vhebron.net

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    &
    Andrés Antón

    Respiratory Virus Unit, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

    Published Online:https://doi.org/10.2217/fmb-2018-0261

    Aim: Human respiratory syncytial virus (HRSV) is the main cause of respiratory tract infections among infants. Materials & methods: In the present study, the molecular epidemiology of HRSV detected from 2013 to 2017 has been described. Results: A 10% of collected samples were laboratory confirmed for HRSV. Patients under 2 years of age were the main susceptible population to respiratory syncytial virus disease, but an increasingly number of confirmed patients over 65 years of age was reported. Epidemics usually started in autumn and ended in spring. Both HRSV groups co-circulated every season, but the HRSV-B was the most predominant. HRSV-A and HRSV-B strains mainly belonged to ON1 and BA9 genotypes, respectively. Conclusion: The present study reports recent data about the genetic diversity of circulating HRSV in Spain.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

    References

    • 1 Blount RE, Morris JA, Savage RE. Recovery of cytopathogenic agent from chimpanzees with coryza. Proc. Soc. Exp. Biol. Med. 92(3), 544–549 (1956).
    • 2 Langley GF, Anderson LJ. Epidemiology and prevention of respiratory syncytial virus infections among infants and young children. Pediatr. Infect. Dis. J. 30(6), 510–517 (2011).
    • 3 Slovic A, Ivancic-Jelecki J, Ljubin-Sternak S, Galinović GM, Forcic D. A molecular epidemiological study of human respiratory syncytial virus in Croatia, 2011-2014. Infect. Genet. Evol. 44, 76–84 (2016).
    • 4 Mazur NI, Martinón-Torres F, Baraldi E et al. Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics. Lancet Respir. Med. 3(11), 888–900 (2015).
    • 5 Rima B, Collins P, Easton A et al. ICTV virus taxonomy profile: pneumoviridae. J. Gen. Virol. doi:10.1099/jgv.0.000959 (2017) (Epub ahead of print).
    • 6 Johnson TR, Graham BS. Contribution of respiratory syncytial virus G antigenicity to vaccine-enhanced illness and the implications for severe disease during primary respiratory syncytial virus infection. Pediatr. Infect. Dis. J. 23(1 Suppl.), S46–S57 (2004).
    • 7 Melero JA, García-Barreno B, Martínez I, Pringle CR, Cane PA. Antigenic structure, evolution and immunobiology of human respiratory syncytial virus attachment (G) protein. J. Gen. Virol. 78(Pt 10), 2411–2418 (1997). •• We have chosen this publication given the study done about the effects suffered by the human respiratory syncytial virus (HRSV) at the antigenic level in the G protein. Its reading will probably improve the comprehension of the work to the reader.
    • 8 Gunson RN, Collins TC, Carman WF. Real-time RT-PCR detection of 12 respiratory viral infections in four triplex reactions. J. Clin. Virol. 33(4), 341–344 (2005).
    • 9 Gimferrer L, Campins M, Codina MG et al. Molecular epidemiology and molecular characterization of respiratory syncytial viruses at a tertiary care university hospital in Catalonia (Spain) during the 2013–2014 season. J. Clin. Virol. 66, 27–32 (2015). • We have highlighted these publication previously made in our laboratory in order to allow the reader to understand the work previously done by our group.
    • 10 Glez-Peña D, Gómez-Blanco D, Reboiro-Jato M, Fdez-Riverola F, Posada D. ALTER: program-oriented conversion of DNA and protein alignments. Nucleic Acids Res. 38, W14–W18 (2010).
    • 11 Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol. Biol. Evol. 33(7), 1870–1874 (2016).
    • 12 Gimferrer L, Andrés C, Campins M et al. Circulation of a novel human respiratory syncytial virus Group B genotype during the 2014-2015 season in Catalonia (Spain). Clin. Microbiol. Infect. doi:10.1016/j.cmi.2015.09.013 (2015) (Epub ahead of print). • We have highlighted these publication previously made in our laboratory in order to allow the reader to understand the work previously done by our group.
    • 13 Broberg EK, Waris M, Johansen K, Snacken R, Penttinen P. European Influenza Surveillance Network. Seasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016. Euro. Surveill. 23(5), doi:10.2807/1560-7917.ES.2018.23.5.17-00284 (2018).
    • 14 Antón A, Marcos MA, Torner N et al. Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain. Clin. Microbiol. Infect. 22(6), 564.e561–e569 (2016).
    • 15 Li X, Li J, Meng L et al. Viral etiologies and epidemiology of patients with acute respiratory infections based on sentinel hospitals in Gansu Province, Northwest China, 2011-2015. J. Med. Virol. doi:10.1002/jmv.25040 (2018) (Epub ahead of print).
    • 16 Petrarca L, Nenna R, Frassanito A et al. Acute bronchiolitis: influence of viral co-infection in infants hospitalized over 12 consecutive epidemic seasons. J. Med. Virol. 90(4), 631–638 (2018).
    • 17 Harada Y, Kinoshita F, Yoshida LM et al. Does respiratory virus coinfection increases the clinical severity of acute respiratory infection among children infected with respiratory syncytial virus? Pediatr. Infect. Dis. J. 32(5), 441–445 (2013).
    • 18 Seki K, Tsutsumi H, Ohsaki M, Kamasaki H, Chiba S. Genetic variability of respiratory syncytial virus subgroup a strain in 15 successive epidemics in one city. J. Med. Virol. 64(3), 374–380 (2001).
    • 19 Agoti CN, Mwihuri AG, Sande CJ et al. Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya. J. Infect. Dis. 206(10), 1532–1541 (2012).
    • 20 Vandini S, Biagi C, Lanari M. Respiratory syncytial virus: the influence of serotype and genotype variability on clinical course of infection. Int. J. Mol. Sci. 18(8), pii:E1717 (2017). • This work reflects the importance of the strain genotyping of the HRSV since it shows that these can have a certain influence on the clinical disease course.
    • 21 Sullender WM, Mufson MA, Anderson LJ, Wertz GW. Genetic diversity of the attachment protein of subgroup B respiratory syncytial viruses. J. Virol. 65(10), 5425–5434 (1991).
    • 22 Gaymard A, Bouscambert-Duchamp M, Pichon M et al. Genetic characterization of respiratory syncytial virus highlights a new BA genotype and emergence of the ON1 genotype in Lyon, France, between 2010 and 2014. J. Clin. Virol. 102, 12–18 (2018).
    • 23 Trento A, Galiano M, Videla C et al. Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides. J. Gen. Virol. 84(Pt 11), 3115–3120 (2003).
    • 24 Katzov-Eckert H, Botosso VF, Neto EA, Zanotto PM, Consortium V. Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children. PLoS ONE 7(10), e41953 (2012).
    • 25 Piñana M, Vila J, Gimferrer L et al. Novel human metapneumovirus with a 180-nucleotide duplication in the G gene. Future Microbiol. 12, 565–571 (2017).
    • 26 Zlateva KT, Vijgen L, Dekeersmaeker N, Naranjo C, Van Ranst M. Subgroup prevalence and genotype circulation patterns of human respiratory syncytial virus in Belgium during ten successive epidemic seasons. J. Clin. Microbiol. 45(9), 3022–3030 (2007).
    • 27 Song J, Wang H, Shi J et al. Emergence of BA9 genotype of human respiratory syncytial virus subgroup B in China from 2006 to 2014. Sci. Rep. 7(1), 16765 (2017).
    • 28 Hirano E, Kobayashi M, Tsukagoshi H et al. Molecular evolution of human respiratory syncytial virus attachment glycoprotein (G) gene of new genotype ON1 and ancestor NA1. Infect. Genet. Evol. 28, 183–191 (2014).
    • 29 Duvvuri VR, Granados A, Rosenfeld P, Bahl J, Eshaghi A, Gubbay JB. Genetic diversity and evolutionary insights of respiratory syncytial virus A ON1 genotype: global and local transmission dynamics. Sci. Rep. 5, 14268 (2015).
    • 30 Tabatabai J, Prifert C, Pfeil J, Grulich-Henn J, Schnitzler P. Novel respiratory syncytial virus (RSV) genotype ON1 predominates in Germany during winter season 2012-13. PLoS ONE 9(10), e109191 (2014).
    • 31 Ábrego LE, Delfraro A, Franco D et al. Genetic variability of human respiratory syncytial virus group B in Panama reveals a novel genotype BA14. J. Med. Virol. 89(10), 1734–1742 (2017).
    • 32 Bayrakdar F, Kocabas CN, Altas AB et al. Genetic variability human respiratory syncytial virus subgroups A and B in Turkey during six successive epidemic seasons, 2009-2015. J. Med. Virol. 90(3), 456–463 (2018).
    • 33 Bashir U, Nisar N, Mahmood N, Alam MM, Sadia H, Zaidi SS. Molecular detection and characterization of respiratory syncytial virus B genotypes circulating in Pakistani children. Infect. Genet. Evol. 47, 125–131 (2017).
    • 34 Venter M, Madhi SA, Tiemessen CT, Schoub BD. Genetic diversity and molecular epidemiology of respiratory syncytial virus over four consecutive seasons in South Africa: identification of new subgroup A and B genotypes. J. Gen. Virol. 82(Pt 9), 2117–2124 (2001).
    • 35 Trento A, Ábrego L, Rodriguez-Fernandez R et al. Conservation of G-protein epitopes in respiratory syncytial virus (Group A) despite broad genetic diversity: is antibody selection involved in virus evolution? J. Virol. 89(15), 7776–7785 (2015). •• This work tries to relate the evolution of the different HRSV genotypes with the host's immune system.
    • 36 Agoti CN, Otieno JR, Ngama M et al. Successive respiratory syncytial virus epidemics in local populations arise from multiple variant introductions, providing insights into virus persistence. J. Virol. 89(22), 11630–11642 (2015).
    • 37 Wilke CO. Bringing molecules back into molecular evolution. PLoS Comput. Biol. 8(6), e1002572 (2012).
    • 38 Posada D. Phylogenetic models of molecular evolution: next-generation data, fit, and performance. J. Mol. Evol. 76(6), 351–352 (2013).