Exercising the brain to avoid cognitive decline: examining the evidence

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Bibliography

• 1  Fernandez A, Goldberg E: The Sharpbrains Guide to Brain Fitness. SharpBrains, San Francisco, CA, USA (2009).
  Google Scholar
• 2  What is dementia: Definitions, pathology and clinical features. Alzheimer’s Disease International: World Alzheimer’s Report14–21 (2009).
  Google Scholar
• 3  Drag LL, Bieliauskas LA: Contemporary review 2009: cognitive aging. J. Geriatr. Psychiatry Neurol.23(2),75–93 (2010).
  MedlineGoogle Scholar
• 4  Lezak MD, Howieson DB, Loring DW: Neuropsychological Assessment (4th Edition). Oxford University Press, NY, USA (2004).
  Google Scholar
• 5  Cattell R: Intelligence: Its Structure, Growth, and Action Elsevier Science Pub. Co., NY, USA (1987).
  Google Scholar
• 6  Miller LJ, Myers A, Prinzi L, Mittenberg W: Changes in intellectual functioning associated with normal aging. Arch. Clin. Neuropsychol.24(7),681–688 (2009).
  MedlineGoogle Scholar
• 7  Petersen RC, Doody R, Kurz A et al.: Current concepts in mild cognitive impairment. Arch. Neurol.58(12),1985–1992 (2001).
  Medline CASGoogle Scholar
• 8  Fisk J, Rockwood K: Outcomes of incident mild cognitive impairment in relation to case definition. J. Neurol. Neurosurg. Psychiatry76(8),1175–1177 (2005).
  Medline CASGoogle Scholar
• 9  Johnson DK, Storandt M, Morris JC, Galvin JE: Longitudinal study of the transition from healthy aging to Alzheimer’s disease. Arch. Neurol.66(10),1254–1259 (2009).
  MedlineGoogle Scholar
• 10  Howieson DB, Carlson NE, Moore MM et al.: Trajectory of mild cognitive impairment onset. J. Int. Neuropsychol. Soc.14(2),192–198 (2008).
  MedlineGoogle Scholar
• 11  Reynolds BA, Weiss S: Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science (New York)255(5052),1707–1710 (1992).
  CASGoogle Scholar
• 12  Rakic P: Neurogenesis in adult primates. Prog. Brain Res.138,3–14 (2002).
  Medline CASGoogle Scholar
• 13  Kolb B, Gibb R: Principles of neuroplasticity and behavior. In: Cognitive Neurorehabilitation: Evidence and Application (2nd Edition). Stuss D, Winocur G, Robertson I (Eds). Cambridge University Press, NY, USA 6–21 (2008).
  Google Scholar
• 14  Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW: β-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol. Learn Mem.66(1),11–23 (1996).
  Medline CASGoogle Scholar
• 15  Rofina JE, Singh K, Skoumalova-Vesela A et al.: Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine. Amyloid11(2),90–100 (2004).
  Medline CASGoogle Scholar
• 16  Rofina JE, van Ederen AM, Toussaint MJ et al.: Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer’s disease. Brain Res.1069(1),216–226 (2006).
  Medline CASGoogle Scholar
• 17  Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW: Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol. Learn Mem.88(2),249–259 (2007).
  Medline CASGoogle Scholar
• 18  Irvine KA, Blakemore WF: Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57Bl/6 mice. J. Neuroimmunol.175(1–2),69–76 (2006).
  Medline CASGoogle Scholar
• 19  Eckles-Smith K, Clayton D, Bickford P, Browning MD: Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression. Brain Res.78(1–2),154–162 (2000).
  CASGoogle Scholar
• 20  Bloss EB, Janssen WG, McEwen BS, Morrison JH: Interactive effects of stress and aging on structural plasticity in the prefrontal cortex. J. Neurosci.30(19),6726–6731 (2010).
  Medline CASGoogle Scholar
• 21  Foy MR, Baudry M, Diaz Brinton R, Thompson RF: Estrogen and hippocampal plasticity in rodent models. J. Alzheimers Dis.15(4),589–603 (2008).
  Medline CASGoogle Scholar
• 22  Dumitriu D, Hao J, Hara Y et al.: Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. J. Neurosci.30(22),7507–7515 (2010).
  Medline CASGoogle Scholar
• 23  Sachdev PS, Valenzuela M: Brain and cognitive reserve. Am. J. Geriat. Psychiatry17(3),175–178 (2009).
  MedlineGoogle Scholar
• 24  Nithianantharajah J, Hannan AJ: Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat. Rev. Neurosci.7(9),697–709 (2006).
  Medline CASGoogle Scholar
• 25  Herring A, Ambree O, Tomm M et al.: Environmental enrichment enhances cellular plasticity in transgenic mice with Alzheimer-like pathology. Exp. Neurol.216(1),184–192 (2009).
  Medline CASGoogle Scholar
• 26  Ambree O, Leimer U, Herring A et al.: Reduction of amyloid angiopathy and abeta plaque burden after enriched housing in tgcrnd8 mice: involvement of multiple pathways. Am. J. Pathol.169(2),544–552 (2006).
  Medline CASGoogle Scholar
• 27  Costa DA, Cracchiolo JR, Bachstetter AD et al.: Enrichment improves cognition in ad mice by amyloid-related and unrelated mechanisms. Neurobiol. Aging28(6),831–844 (2007).
  Medline CASGoogle Scholar
• 28  Hu YS, Xu P, Pigino G, Brady ST, Larson J, Lazarov O: Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPsew/PS1dE9 mice. FASEB J.24(6),1667–1681 (2010).
  Medline CASGoogle Scholar
• 29  Katzman R, Terry R, Deteresa R et al.: Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann. Neurol.23(2),138–144 (1988).
  Medline CASGoogle Scholar
• 30  Brickman AM, Siedlecki KL, Stern Y: Cognitive and Brain Reserve. In: Successful Cognitive and Emotional Aging. Depp CA, Jeste DV (Eds). American Psychiatric Publishing, Inc; Arlington, USA 157–172 (2010).• Excellent comprehensive review of the neurobiological basis underlying the potential for adults to gain benefit from cognitive exercise.
  Google Scholar
• 31  Valenzuela MJ, Breakspear M, Sachdev P: Complex mental activity and the aging brain: molecular, cellular and cortical network mechanisms. Brain Res. Rev.56(1),198–213 (2007).
  Medline CASGoogle Scholar
• 32  Pereira AC, Huddleston DE, Brickman AM et al.: An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc. Natl Acad. Sci. USA104(13),5638–5643 (2007).
  Medline CASGoogle Scholar
• 33  Stern Y, Habeck C, Moeller J et al.: Brain networks associated with cognitive reserve in healthy young and old adults. Cereb. Cortex15(4),394–402 (2005).
  MedlineGoogle Scholar
• 34  Verghese J, Lipton RB, Katz MJ et al.: Leisure activities and the risk of dementia in the elderly. N. Engl. J. Med.348(25),2508–2516 (2003).• Seminal paper describing the association between choice of recreational and leisure activities in older adults and the risk of dementia.
  MedlineGoogle Scholar
• 35  Karp A, Andel R, Parker MG, Wang HX, Winblad B, Fratiglioni L: Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen project. Am. J. Geriatr. Psychiatry17(3),227–236 (2009).
  MedlineGoogle Scholar
• 36  Wilson R, Barnes L, Bennett D: Assessment of lifetime participation in cognitively stimulating activities. J. Clin. Exp. Neuropsychol25(5),634–642 (2003).
  MedlineGoogle Scholar
• 37  Wilson RS, Bennett DA, Bienias JL et al.: Cognitive activity and incident ad in a population-based sample of older persons. Neurology59(12),1910–1914 (2002).
  Medline CASGoogle Scholar
• 38  Fritsch T, Smyth KA, Debanne SM, Petot GJ, Friedland RP: Participation in novelty-seeking leisure activities and Alzheimer’s disease. J. Geriat. Psychiatry Neurol.18(3),134–141 (2005).
  MedlineGoogle Scholar
• 39  Helzner EP, Scarmeas N, Cosentino S, Portet F, Stern Y: Leisure activity and cognitive decline in incident alzheimer disease. Arch. Neurol.64(12),1749–1754 (2007).
  MedlineGoogle Scholar
• 40  Stern Y, Albert S, Tang MX, Tsai WY: Rate of memory decline in ad is related to education and occupation: cognitive reserve? Neurology53(9),1942–1947 (1999).
  Medline CASGoogle Scholar
• 41  Hall CB, Lipton RB, Sliwinski M, Katz MJ, Derby CA, Verghese J: Cognitive activities delay onset of memory decline in persons who develop dementia. Neurology73(5),356–361 (2009).
  Medline CASGoogle Scholar
• 42  Stern Y: What is cognitive reserve? Theory and research application of the reserve concept. J. Int. Neuropsychol. Soc.8(3),448–460 (2002).
  MedlineGoogle Scholar
• 43  Sitzer DI, Twamley EW, Jeste DV: Cognitive training in Alzheimer’s disease: a meta-analysis of the literature. Acta. Psychiatr. Scand.114(2),75–90 (2006).• Comprehensive meta-analysis of the literature reporting the effects of cognitive training for Alzheimer’s disease.
  Medline CASGoogle Scholar
• 44  Valenzuela M, Sachdev P: Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up. Am. J. Geriatr. Psychiatry17(3),179–187 (2009).• Excellent review of whether cognitive exercise and other means of intellectual stimulation have been demonstrated to prevent dementia.
  MedlineGoogle Scholar
• 45  Papp KV, Walsh SJ, Snyder PJ: Immediate and delayed effects of cognitive interventions in healthy elderly: a review of current literature and future directions. Alzheimers Dement.5(1),50–60 (2009).
  MedlineGoogle Scholar
• 46  Willis SL, Tennstedt SL, Marsiske M et al.: Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA296(23),2805–2814 (2006).
  Medline CASGoogle Scholar
• 47  Jobe JB, Smith DM, Ball K et al.: Active: a cognitive intervention trial to promote independence in older adults. Control Clin. Trials22(4),453–479 (2001).• Largest and, perhaps, most informative study ever carried out examining the long-term effects of cognitive training in healthy adults, the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study.
  Medline CASGoogle Scholar
• 48  Ball K, Berch DB, Helmers KF et al.: Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA288(18),2271–2281 (2002).
  MedlineGoogle Scholar
• 49  Wolinsky FD, Unverzagt FW, Smith DM, Jones R, Wright E, Tennstedt SL: The effects of the active cognitive training trial on clinically relevant declines in health-related quality of life. J. Gerontol. B Psychol. Sci. Soc. Sci.61(5),S281–S287 (2006).
  MedlineGoogle Scholar
• 50  Mahncke HW, Connor BB, Appelman J et al.: Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc. Natl Acad. Sci. USA103(33),12523–12528 (2006).
  Medline CASGoogle Scholar
• 51  Smith GE, Housen P, Yaffe K et al.: A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-Based Adaptive Cognitive Training (IMPACT) study. J. Am. Geriatr. Soc.57(4),594–603 (2009).• Especially rigorous scientific study of the potential benefits of a computerized cognitive training program for healthy adults developed by a commercial entity, Posit Science (CA, USA).
  MedlineGoogle Scholar
• 52  Engvig A, Fjell AM, Westlye LT, Moberget T, Sundseth Ø: Effects of memory training on cortical thickness in the elderly. NeuroImage52,1667–1676 (2010).
  MedlineGoogle Scholar
• 53  Kurz A, Pohl C, Ramsenthaler M, Sorg C: Cognitive rehabilitation in patients with mild cognitive impairment. Int. J. Geriatr. Psychiatry24(2),163–168 (2009).
  MedlineGoogle Scholar
• 54  Troyer AK, Murphy KJ, Anderson ND, Moscovitch M, Craik FI: Changing everyday memory behaviour in amnestic mild cognitive impairment: a randomised controlled trial. Neuropsychol. Rehabil.18(1) (2008).
  MedlineGoogle Scholar
• 55  Belleville S, Gilbert B, Fontaine F, Gagnon L, Menard E, Gauthier S: Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: evidence from a cognitive intervention program. Dement. Geriatr. Cogn. Disord.22(5–6),486–499 (2006).
  MedlineGoogle Scholar
• 56  Clare L, Woods RT, Moniz Cook ED, Orrell M, Spector A: Cognitive rehabilitation and cognitive training for early-stage alzheimer’s disease and vascular dementia. Cochrane Database Syst. Rev. (4),CD003260 (2003).
  MedlineGoogle Scholar
• 57  de Medeiros K, Kennedy Q, Cole T, Lindley R, O’Hara, R: The impact of autobiographic writing on memory performance in older adults: a preliminary investigation. Am. J. Geriatr. Psychiatry15(3),257–261 (2007).
  MedlineGoogle Scholar
• 58  Noice H, Noice T, Staines G: A short-term intervention to enhance cognitive and affective functioning in older adults. J. Aging Health16(4),562–585 (2004).
  MedlineGoogle Scholar
• 59  Noice H, Noice T: An arts intervention for older adults living in subsidized retirement homes. Neuropsychol. Dev. Cogn B Aging Neuropsychol. Cogn.16(1),56–79 (2009).
  MedlineGoogle Scholar
• 60  Fried LP, Carlson M, Freedman F, Frick KD, Glass TA, Hill J: A social model for health promotion for an aging population: initial evidence on the experience corps model. J. Urban Health81,64–78 (2004).
  MedlineGoogle Scholar
• 61  Carlson MC, Saczynski JS, Rebok GW et al.: Exploring the effects of an ‘everyday’ activity program on executive function and memory in older adults: Experience Corps. Gerontologist48(6),793–801 (2008).• Very interesting study examining the cognition enhancing benefits for seniors participating in an intensive volunteer program entitled Experience Corps®.
  MedlineGoogle Scholar
• 62  Carlson MC, Erickson KI, Kramer AF et al.: Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J. Gerontol.64(12),1275–1282 (2009).
  Google Scholar
• 63  Laurin D, Verreault R, Lindsay J, Macpherson K, Rockwood K: Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch. Neurol.58(3),498–504 (2001).
  Medline CASGoogle Scholar
• 64  Lytle ME, Vander Bilt J, Pandav RS, Dodge HH, Ganguli M: Exercise level and cognitive decline: the movies project. Alzheimer Dis. Assoc. Disord.18(2),57–64 (2004).
  MedlineGoogle Scholar
• 65  Kamphuis PJ, Scheltens P: Can nutrients prevent or delay onset of Alzheimer’s disease? J. Alzheimers Dis.20(3),765–775 (2010).
  MedlineGoogle Scholar
• 66  Seeman TE, Lusignolo TM, Albert M, Berkman L: Social relationships, social support, and patterns of cognitive aging in healthy, high-functioning older adults: Macarthur studies of successful aging. Health Psychol.20(4),243–255 (2001).
  Medline CASGoogle Scholar
• 67  Holtzman RE, Rebok GW, Saczynski JS, Kouzis AC, Wilcox Doyle K, Eaton WW: Social network characteristics and cognition in middle-aged and older adults. J. Gerontol. B Psychol. Sci. Soc. Sci.59(6),P278–P284 (2004).
  MedlineGoogle Scholar
• 68  Bendlin BB, Canu E, Willette A et al.: Effects of aging and calorie restriction on white matter in rhesus macaques. Neurobiol. Aging (2010) (Epub ahead of print).
  Google Scholar
• 69  Colman RJ, Anderson RM, Johnson SC et al.: Caloric restriction delays disease onset and mortality in Rhesus monkeys. Science325(5937),201–204 (2009).
  Medline CASGoogle Scholar
• 70  Opalach K, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L: Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Res.13(1),65–74 (2010).
  Medline CASGoogle Scholar
• 71  Bednarczyk MR, Hacker LC, Fortin-Nunez S, Aumont A, Bergeron R, Fernandes KJ: Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment. Hippocampus (2010) (Epub ahead of print).
  MedlineGoogle Scholar
• 72  Erickson KI, Prakash RS, Voss MW et al.: Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus19(10),1030–1039 (2009).
  MedlineGoogle Scholar
• 73  Kramer AF, Erickson KI: Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. Trends Cogn. Sci.11(8),342–348 (2007).
  MedlineGoogle Scholar
• 74  Klusmann V, Evers A, Schwarzer R et al.: Complex mental and physical activity in older women and cognitive performance: a 6-month randomized controlled trial. J. Gerontol.65(6),680–688 (2010).
  Google Scholar
• 75  Small GW, Silverman DH, Siddarth P et al.: Effects of a 14-day healthy longevity lifestyle program on cognition and brain function. Am. J. Geriatr. Psychiatry14(6),538–545 (2006).
  MedlineGoogle Scholar
• 76  National Institute of Health State-of-the-Science Conference Statement: preventing Alzheimer’s disease and cognitive decline. In: NIH Consensus Development Program. Bethesda, MA, USA (2010).
  Google Scholar
• 77  Owen AM, Hampshire A, Grahn JA et al.: Putting brain training to the test. Nature465(7299),775–778 (2010).
  Medline CASGoogle Scholar
• 78  Sliwinski M, Buschke H, Stewart WF, Masur D, Lipton RB: The effect of dementia risk factors on comparative and diagnostic selective reminding norms. J. Int. Neuropsychol. Soc.3(4),317–326 (1997).
  Medline CASGoogle Scholar
• 79  Barnes De, Yaffe K, Belfor N et al.: Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis. Assoc. Disord.23(3),205–210 (2009).
  MedlineGoogle Scholar
• 80  Rozzini L, Costardi D, Chilovi BV, Franzoni S, Trabucchi M, Padovani A: Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. Int. J. Geriatr. Psychiatry22(4),356–360 (2007).
  MedlineGoogle Scholar
• 81  Rapp S, Brenes G, Marsh AP: Memory enhancement training for older adults with mild cognitive impairment: a preliminary study. Aging Ment. Health6(1),5–11 (2002).
  Medline CASGoogle Scholar
• 82  Requena C, Maestu F, Campo P, Fernandez A, Ortiz T: Effects of cholinergic drugs and cognitive training on dementia: 2-year follow-up. Dement. Geriatr. Cogn. Disord.22(4),339–345 (2006).
  Medline CASGoogle Scholar
• 83  Galante E, Venturini G, Fiaccadori C: Computer-based cognitive intervention for dementia: preliminary results of a randomized clinical trial. G. Ital. Med. Lav. Ergon.29(Suppl. 3B),B26–B32 (2007).
  Medline CASGoogle Scholar
• 84  Cahn-Weiner DA, Malloy PF, Rebok GW, Ott BR: Results of a randomized placebo-controlled study of memory training for mildly impaired Alzheimer’s disease patients. Appl. Neuropsychol.10(4),215–223 (2003).
  MedlineGoogle Scholar
• 85  Loewenstein DA, Acevedo A, Czaja SJ, Duara R: Cognitive rehabilitation of mildly impaired Alzheimer’s disease patients on cholinesterase inhibitors. Am. J. Geriatr. Psychiatry12(4),395–402 (2004).
  MedlineGoogle Scholar
• 86  Olazaran J, Muniz R, Reisberg B et al.: Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology63(12),2348–2353 (2004).
  Medline CASGoogle Scholar
• 87  Davis RN, Massman PJ, Doody RS: Cognitive intervention in Alzheimer disease: a randomized placebo-controlled study. Alzheimer Dis. Assoc. Disord.15(1),1–9 (2001).
  Medline CASGoogle Scholar
• 88  Tarraga L, Boada M, Modinos G et al.: A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer’s disease. J. Neurol. Neurosurg. Psychiatry77(10),1116–1121 (2006).
  Medline CASGoogle Scholar