Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated compounds with some common therapeutic actions and side effects. They have potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. It is generally thought that one of their main mechanisms of action is the inhibition of cyclo-oxygenase (COX), the enzyme responsible for biosynthesing the prostaglandins and thromboxane. NSAIDs are also associated with an increased risk of adverse gastrointestinal, renal and cardiovascular effects. This review describes the clinical pharmacology of NSAIDs, their classification, molecular mechanisms of action and adverse effects, including their possible contribution to neuro-inflammation and carcinogenesis, as well as some recent developments aimed at designing effective anti-inflammatory agents with improved safety and tolerability profiles.
Keywords: NSAIDs, cyclo-oxygenases, prostanoids, adverse effects, cancer, neuro-inflammation, safe NSAIDs, Non-Steroidal Anti-Inflammatory Drugs, selective COX-2 inhibitors , COXIBs, COX-1 , COX-2 , enzyme catalysis , cytoprotection, Hydrogen sulfide-releasing non-steroidal anti-inflammatory, Nitric oxide-releasing non-steroidal anti-inflammatory
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Clinical Pharmacology of Non-Steroidal Anti-Inflammatory Drugs: A Review
Volume: 11 Issue: 1
Author(s): S. Bacchi, P. Palumbo, A. Sponta and M.F. Coppolino
Affiliation:
Keywords: NSAIDs, cyclo-oxygenases, prostanoids, adverse effects, cancer, neuro-inflammation, safe NSAIDs, Non-Steroidal Anti-Inflammatory Drugs, selective COX-2 inhibitors , COXIBs, COX-1 , COX-2 , enzyme catalysis , cytoprotection, Hydrogen sulfide-releasing non-steroidal anti-inflammatory, Nitric oxide-releasing non-steroidal anti-inflammatory
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated compounds with some common therapeutic actions and side effects. They have potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. It is generally thought that one of their main mechanisms of action is the inhibition of cyclo-oxygenase (COX), the enzyme responsible for biosynthesing the prostaglandins and thromboxane. NSAIDs are also associated with an increased risk of adverse gastrointestinal, renal and cardiovascular effects. This review describes the clinical pharmacology of NSAIDs, their classification, molecular mechanisms of action and adverse effects, including their possible contribution to neuro-inflammation and carcinogenesis, as well as some recent developments aimed at designing effective anti-inflammatory agents with improved safety and tolerability profiles.
Export Options
About this article
Cite this article as:
Bacchi S., Palumbo P., Sponta A. and Coppolino M.F., Clinical Pharmacology of Non-Steroidal Anti-Inflammatory Drugs: A Review, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2012; 11 (1) . https://dx.doi.org/10.2174/187152312803476255
DOI https://dx.doi.org/10.2174/187152312803476255 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Shock Garments for Obstetric Hemorrhage
Current Women`s Health Reviews Protein Kinases and their Modulation in the Central Nervous System
Current Medicinal Chemistry - Central Nervous System Agents Extracellular Hsp70: Export and Function
Current Protein & Peptide Science Contrast-Induced Nephropathy after Endovascular Aneurysm Repair, Carotid and Peripheral Interventions
Current Vascular Pharmacology Drug-Eluting Stents: Present and Future
Cardiovascular & Hematological Agents in Medicinal Chemistry The Hellp Syndrome: A Review
Current Women`s Health Reviews Gender Differences in the Effects of Angiotensin Receptor Blockers on Cardiovascular Disease
Current Pharmaceutical Design Multidrug-Resistance (MDR) Proteins Develops Refractory Epilepsy Phenotype:Clinical and Experimental Evidences
Current Drug Therapy Mikuliczs Disease and its Extraglandular Lesions
Current Immunology Reviews (Discontinued) Does Pharmacological Therapy Still Play a Role in Preventing Sudden Death in Surgically Treated Tetralogy of Fallot?
Mini-Reviews in Medicinal Chemistry <i>In silico</i> Approach for Exploring the Role of AT1R Polymorphism on its Function, Structure and Drug Interactions
Current Computer-Aided Drug Design Amphetamine-Type Medicines: A Review of Pharmacokinetics, Pharmacodynamics, and Toxicological Aspects.
Current Clinical Pharmacology Therapeutic Applications of Prostaglandins and Thromboxane A2 Inhibitors in Abdominal Aortic Aneurysms
Current Drug Targets Evaluation of Application Value of Transcranial Doppler (TCD) in the Inspection of Cerebral Vasospasm After the Treatment of Intracranial Aneurysm
Current Medical Imaging Delayed Cerebral Ischemia after Subarachnoid Hemorrhage: From Vascular Spasm to Cortical Spreading Depolarizations
Current Neurovascular Research Early Cerebral Infarction Following Aneurysmal Subarachnoid Hemorrhage: Frequency, Risk Factors, Patterns, and Prognosis
Current Neurovascular Research Optical Imaging of Microvascular Morphology and Perfusion
Current Angiogenesis (Discontinued) The Influence of Acute Phase Proteins on Murine Atherosclerosis
Current Drug Targets From Biomarkers to Cytokine-like Hormones: Uncovering New Directives for Cognitive Loss and Alzheimer’s Disease
Current Neurovascular Research Marfan Syndrome and Related Heritable Thoracic Aortic Aneurysms and Dissections
Current Pharmaceutical Design