Abstract
Man has relied on plants as a source of medicinal agents for centuries. Today, with the specter of antibiotic resistance, emerging infectious diseases, and cancers, phytochemicals continue to provide new structural leads for the chemotherapeutic industry. A number of triterpenoids have shown promise as antineoplastic agents. Members of the cycloartane, lupane, ursane, oleanane, friedelane (especially quinone methides), dammarane, cucurbitacin, and limonoid triterpenoids, have demonstrated anti-proliferative activity on various cancer cell lines. This review covers the recent developments regarding antineoplastic / cytotoxic triterpenoids, excluding saponins, from higher plants.
Keywords: triterpenoids, cytotoxic, antineoplastic, cancer
Mini-Reviews in Medicinal Chemistry
Title: Plant-Derived Triterpenoids as Potential Antineoplastic Agents
Volume: 3 Issue: 6
Author(s): W. N. Setzer and M. C. Setzer
Affiliation:
Keywords: triterpenoids, cytotoxic, antineoplastic, cancer
Abstract: Man has relied on plants as a source of medicinal agents for centuries. Today, with the specter of antibiotic resistance, emerging infectious diseases, and cancers, phytochemicals continue to provide new structural leads for the chemotherapeutic industry. A number of triterpenoids have shown promise as antineoplastic agents. Members of the cycloartane, lupane, ursane, oleanane, friedelane (especially quinone methides), dammarane, cucurbitacin, and limonoid triterpenoids, have demonstrated anti-proliferative activity on various cancer cell lines. This review covers the recent developments regarding antineoplastic / cytotoxic triterpenoids, excluding saponins, from higher plants.
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Cite this article as:
Setzer N. W. and Setzer C. M., Plant-Derived Triterpenoids as Potential Antineoplastic Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487854
DOI https://dx.doi.org/10.2174/1389557033487854 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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