Abstract
Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.
Keywords: Chemoprevention, Phytochemicals, Activator protein-1, Nuclear factor (NF)-κB, Cyclooxygenase (COX)-2, Apoptosis, Cell cycle arrest, Angiogenesis, Oxidative stress, Curcumin, (-)-epigallocatechin-3-gallate, Resveratrol, Isothyocynates
Anti-Cancer Agents in Medicinal Chemistry
Title:Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets
Volume: 12 Issue: 10
Author(s): Poyil Pratheeshkumar, Chakkenchath Sreekala, Zhuo Zhang, Amit Budhraja, Songze Ding, Young-Ok Son, Xin Wang, Andrew Hitron, Kim Hyun-Jung, Lei Wang, Jeong-Chae Lee and Xianglin Shi
Affiliation:
Keywords: Chemoprevention, Phytochemicals, Activator protein-1, Nuclear factor (NF)-κB, Cyclooxygenase (COX)-2, Apoptosis, Cell cycle arrest, Angiogenesis, Oxidative stress, Curcumin, (-)-epigallocatechin-3-gallate, Resveratrol, Isothyocynates
Abstract: Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.
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Pratheeshkumar Poyil, Sreekala Chakkenchath, Zhang Zhuo, Budhraja Amit, Ding Songze, Son Young-Ok, Wang Xin, Hitron Andrew, Hyun-Jung Kim, Wang Lei, Lee Jeong-Chae and Shi Xianglin, Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (10) . https://dx.doi.org/10.2174/187152012803833035
DOI https://dx.doi.org/10.2174/187152012803833035 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
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