Abstract
Cough is among the most common complaints for which patients seek medical attention, yet available therapies are woefully inadequate. Better and more effective cough suppressants are desperately needed, as currently available antitussives are limited by inconsistent efficacy and bothersome or intolerable side effects. As research in the field of cough continues to grow, inhalation cough challenge, which allows the measurement of cough reflex sensitivity and its modulation by pharmacological and other interventions, will assume ever greater importance. The ability of inhalation cough challenge to measure cough reflex sensitivity in a safe and reproducible manner has been clearly demonstrated in several decades of clinical experience. To assure quality data from cough challenge studies, careful consideration of study populations, as well as meticulous attention to the methodology of the cough challenge procedure, are essential.
Keywords: Cough, antitussive, capsaicin, inhalation challenge
Current Respiratory Medicine Reviews
Title: Inhalation Cough Challenge
Volume: 6 Issue: 2
Author(s): Peter V. Dicpinigaitis
Affiliation:
Keywords: Cough, antitussive, capsaicin, inhalation challenge
Abstract: Cough is among the most common complaints for which patients seek medical attention, yet available therapies are woefully inadequate. Better and more effective cough suppressants are desperately needed, as currently available antitussives are limited by inconsistent efficacy and bothersome or intolerable side effects. As research in the field of cough continues to grow, inhalation cough challenge, which allows the measurement of cough reflex sensitivity and its modulation by pharmacological and other interventions, will assume ever greater importance. The ability of inhalation cough challenge to measure cough reflex sensitivity in a safe and reproducible manner has been clearly demonstrated in several decades of clinical experience. To assure quality data from cough challenge studies, careful consideration of study populations, as well as meticulous attention to the methodology of the cough challenge procedure, are essential.
Export Options
About this article
Cite this article as:
V. Dicpinigaitis Peter, Inhalation Cough Challenge, Current Respiratory Medicine Reviews 2010; 6 (2) . https://dx.doi.org/10.2174/157339810791171269
DOI https://dx.doi.org/10.2174/157339810791171269 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Prospects for Caspase Inhibitors
Mini-Reviews in Medicinal Chemistry Covalently and Ionically Crosslinked Chitosan Nanogels for Drug Delivery
Current Pharmaceutical Design Neurovascular Signals Suggest a Propagation Mechanism for Endogenous Stem Cell Activation Along Blood Vessels
CNS & Neurological Disorders - Drug Targets WNT Signaling in Stem Cell Biology and Regenerative Medicine
Current Drug Targets Imaging Modalities in the Outcome Assessment of Knee Osteoarthritis
Current Rheumatology Reviews Pharmacological Support of Neurorehabilitation
Current Drug Therapy Antibodies As Promising Novel Neuroprotective Agents in the Central Nervous System Injuries
Central Nervous System Agents in Medicinal Chemistry Antioxidant Properties of Nitric Oxide in Cellular Physiological and Pathophysiological Mechanisms. The Implications of Biological Balance between NO and Oxidative Stress
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Neuropharmacology of Stress-Induced Mucosal Inflammation: Implications for Inflammatory Bowel Disease and Irritable Bowel Syndrome
Current Molecular Medicine What Makes Y Family Pols Potential Candidates for Molecular Targeted Therapies and Novel Biotechnological Applications
Current Molecular Medicine Gabapentin-Mediated Effects on Voltage- and Ligand-Gated Currents
Current Neuropharmacology Nanotechnologies: A Strategy to Overcome Blood-Brain Barrier
Current Drug Metabolism Beyond Rodent Models of Pain: Non-Human Primate Models for Evaluating Novel Analgesic Therapeutics and Elaborating Pain Mechanisms
CNS & Neurological Disorders - Drug Targets Pharmacological Activity of Cardiovascular Agents from Herbal Medicine
Cardiovascular & Hematological Agents in Medicinal Chemistry Utilizing Delta Opioid Receptors and Peptides for Cytoprotection: Implications in Stroke and Other Neurological Disorders
CNS & Neurological Disorders - Drug Targets Human Pluripotent Stem Cells for Spinal Cord Injury
Current Stem Cell Research & Therapy Editorial (Hot Topic: Palmitoylethanolamide: Biochemistry, Pharmacology and Therapeutic Use of a Pleiotropic Anti-Inflammatory Lipid Mediator)
CNS & Neurological Disorders - Drug Targets New Perspectives in the Pharmacological Potential of Naringin in Medicine
Current Medicinal Chemistry Collective Roles of Molecular Chaperones in Protein Degradation Pathways Associated with Neurodegenerative Diseases
Current Pharmaceutical Biotechnology Tetracyclines and Pulmonary Inflammation
Endocrine, Metabolic & Immune Disorders - Drug Targets