Abstract
Drug abuse and HIV infection are interlinked. From the onset of the HIV/AIDS epidemic, the impact of illicit drug use on HIV disease progression has been a focus of many investigations. Both laboratory-based and epidemiological studies strongly indicate that drug abuse may exacerbate HIV disease progression and increase mortality and morbidity in these patients. Increase susceptibility to opportunistic infection has been implicated as one of the major causes for this detriment. Furthermore, opioids are known to elicit prevalence of neurodegenerative disorders in HIV-infected patients. Numerous authors have delineated various molecular as well as cellular mechanisms associated with neurological complications in these patients. This review gives an overview of these findings. Understanding the mechanisms will allow for the development of targeted therapies aimed at reducing the progression of neurocognitive decline in the drug abusing HIV infected individuals.
Keywords: Opioid, HAND, microglia, astrocyte, neuron, TLR, opportunistic infection, CNS, HIV, IDUs.
Current HIV Research
Title:Mechanism(s) Involved in Opioid Drug Abuse Modulation of HAND
Volume: 10 Issue: 5
Author(s): Raini Dutta and Sabita Roy
Affiliation:
Keywords: Opioid, HAND, microglia, astrocyte, neuron, TLR, opportunistic infection, CNS, HIV, IDUs.
Abstract: Drug abuse and HIV infection are interlinked. From the onset of the HIV/AIDS epidemic, the impact of illicit drug use on HIV disease progression has been a focus of many investigations. Both laboratory-based and epidemiological studies strongly indicate that drug abuse may exacerbate HIV disease progression and increase mortality and morbidity in these patients. Increase susceptibility to opportunistic infection has been implicated as one of the major causes for this detriment. Furthermore, opioids are known to elicit prevalence of neurodegenerative disorders in HIV-infected patients. Numerous authors have delineated various molecular as well as cellular mechanisms associated with neurological complications in these patients. This review gives an overview of these findings. Understanding the mechanisms will allow for the development of targeted therapies aimed at reducing the progression of neurocognitive decline in the drug abusing HIV infected individuals.
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Cite this article as:
Dutta Raini and Roy Sabita, Mechanism(s) Involved in Opioid Drug Abuse Modulation of HAND, Current HIV Research 2012; 10 (5) . https://dx.doi.org/10.2174/157016212802138805
DOI https://dx.doi.org/10.2174/157016212802138805 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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