Abstract
We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infection, especially viral infection of resting macrophages. We also describe the possible involvement of Vpr in non-AIDS-defining cancers, which represent an emerging crisis in HIV-1-positive patients.
Keywords: HIV-1, Vpr, DNA double-strand breaks, ATM, homologous recombination, non-AIDS-defining cancers
Current HIV Research
Title: Vpr-Induced DNA Double-Strand Breaks: Molecular Mechanism and Biological Relevance
Volume: 7 Issue: 2
Author(s): Chikako Nakai-Murakami, Yuzuru Minemoto and Yukihito Ishizaka
Affiliation:
Keywords: HIV-1, Vpr, DNA double-strand breaks, ATM, homologous recombination, non-AIDS-defining cancers
Abstract: We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infection, especially viral infection of resting macrophages. We also describe the possible involvement of Vpr in non-AIDS-defining cancers, which represent an emerging crisis in HIV-1-positive patients.
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Cite this article as:
Nakai-Murakami Chikako, Minemoto Yuzuru and Ishizaka Yukihito, Vpr-Induced DNA Double-Strand Breaks: Molecular Mechanism and Biological Relevance, Current HIV Research 2009; 7 (2) . https://dx.doi.org/10.2174/157016209787581391
DOI https://dx.doi.org/10.2174/157016209787581391 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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