Abstract
Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families. Due to the concurrent increase in life expectancy, the incidence of these diseases has been increasing over the last years and thus there is a growing interest in finding potential risk factors. This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson's disease, especially through the so called gut-brain axis.
Keywords: Gut-brain axis, Inflammatory bowel disease, Microglia, Neurodegeneration, Parkinson’s disease, Peripheral inflammation.
Current Topics in Medicinal Chemistry
Title:Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases
Volume: 15 Issue: 21
Author(s): Antonio J. Herrera, Ana M. Espinosa-Oliva, Maria J. Oliva-Martin, Alejandro Carrillo-Jimenez, Jose L. Venero and Rocio M. de Pablos
Affiliation:
Keywords: Gut-brain axis, Inflammatory bowel disease, Microglia, Neurodegeneration, Parkinson’s disease, Peripheral inflammation.
Abstract: Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families. Due to the concurrent increase in life expectancy, the incidence of these diseases has been increasing over the last years and thus there is a growing interest in finding potential risk factors. This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson's disease, especially through the so called gut-brain axis.
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Cite this article as:
Herrera J. Antonio, Espinosa-Oliva M. Ana, Oliva-Martin J. Maria, Carrillo-Jimenez Alejandro, Venero L. Jose and de Pablos M. Rocio, Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases, Current Topics in Medicinal Chemistry 2015; 15 (21) . https://dx.doi.org/10.2174/1568026615666150610142027
DOI https://dx.doi.org/10.2174/1568026615666150610142027 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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