Abstract
Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.
Keywords: Calcineurin, cancer, inflammation, NFAT, nuclear export, nuclear import
Current Molecular Medicine
Title:NFAT Gene Family in Inflammation and Cancer
Volume: 13 Issue: 4
Author(s): M.-G. Pan, Y. Xiong and F. Chen
Affiliation:
Keywords: Calcineurin, cancer, inflammation, NFAT, nuclear export, nuclear import
Abstract: Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.
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Cite this article as:
Pan M.-G., Xiong Y. and Chen F., NFAT Gene Family in Inflammation and Cancer, Current Molecular Medicine 2013; 13 (4) . https://dx.doi.org/10.2174/1566524011313040007
DOI https://dx.doi.org/10.2174/1566524011313040007 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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