Abstract
Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.
Keywords: Angiogenesis, tumor, COP9 signalosome, curcumin, emodin, taurolidine
Mini-Reviews in Medicinal Chemistry
Title: Novel Anti-Angiogenic Compounds for Application in Tumor Therapy – COP9 Signalosome-Associated Kinases as Possible Targets
Volume: 8 Issue: 5
Author(s): Chris Braumann, Judith Tangermann, Christoph A. Jacobi, Joachim M. Muller and Wolfgang Dubiel
Affiliation:
Keywords: Angiogenesis, tumor, COP9 signalosome, curcumin, emodin, taurolidine
Abstract: Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.
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Cite this article as:
Braumann Chris, Tangermann Judith, Jacobi A. Christoph, Muller M. Joachim and Dubiel Wolfgang, Novel Anti-Angiogenic Compounds for Application in Tumor Therapy – COP9 Signalosome-Associated Kinases as Possible Targets, Mini-Reviews in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/138955708784223549
DOI https://dx.doi.org/10.2174/138955708784223549 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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