Abstract
In last few years, the use of zebrafish (Danio rerio) in scientific research is growing very rapidly. Initially, it was a popular as a model of vertebrate development because zebrafish embryos are transparent and also develop rapidly. Presently, the research using zebrafish is expanding into other areas such as pharmacology, clinical research as a diseases model and interestingly in drug discovery. The use of zebrafish in pharmaceutical research and discovery and drug development is mainly screening of lead compounds, target identification, target validation, morpholino oligonucleotide screens, assay development for drug discovery, physiology based drug discovery, quantitative structure-activity relationship (QSAR) and structure – activity relationships (SAR) study and drug toxicity study. In this paper, we have described properly all the areas of dug discovery where zebrafish is used as a tool. We are hopeful that the use of these techniques or methods will make the zebrafish a prominent model in drug discovery and development research in the forthcoming years.
Keywords: Zebrafish, animal model, in vivo drug discovery, physiology based drug discovery, screening of compounds, target identification, target validation, drug toxicity study
Current Drug Metabolism
Title: Zebrafish: A Complete Animal Model for In Vivo Drug Discovery and Development
Volume: 10 Issue: 2
Author(s): Chiranjib Chakraborty, Chi Hsin Hsu, Zhi Hong Wen, Chang Shing Lin and Govindasamy Agoramoorthy
Affiliation:
Keywords: Zebrafish, animal model, in vivo drug discovery, physiology based drug discovery, screening of compounds, target identification, target validation, drug toxicity study
Abstract: In last few years, the use of zebrafish (Danio rerio) in scientific research is growing very rapidly. Initially, it was a popular as a model of vertebrate development because zebrafish embryos are transparent and also develop rapidly. Presently, the research using zebrafish is expanding into other areas such as pharmacology, clinical research as a diseases model and interestingly in drug discovery. The use of zebrafish in pharmaceutical research and discovery and drug development is mainly screening of lead compounds, target identification, target validation, morpholino oligonucleotide screens, assay development for drug discovery, physiology based drug discovery, quantitative structure-activity relationship (QSAR) and structure – activity relationships (SAR) study and drug toxicity study. In this paper, we have described properly all the areas of dug discovery where zebrafish is used as a tool. We are hopeful that the use of these techniques or methods will make the zebrafish a prominent model in drug discovery and development research in the forthcoming years.
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Cite this article as:
Chakraborty Chiranjib, Hsu Hsin Chi, Wen Hong Zhi, Lin Shing Chang and Agoramoorthy Govindasamy, Zebrafish: A Complete Animal Model for In Vivo Drug Discovery and Development, Current Drug Metabolism 2009; 10 (2) . https://dx.doi.org/10.2174/138920009787522197
DOI https://dx.doi.org/10.2174/138920009787522197 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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