Abstract
Peripheral arterial disease (PAD) affects a large number of individuals over the age of 55 years old, and data from studies has shown a relationship between inflammation, and PAD. Many researchers have not only focused on the role played by inflammatory biomarkers and the progression of PAD, but also on the efficiency of biomarkers in monitoring medical, surgical and interventional strategies in PAD patients. In this review, Authors aim to demonstrate that biomarkers play a key role in the pathophysiology of PAD, and consequently they could be screened to highlight individuals showing these crucial pathophysiological signs. Based on a large debate about phlogosis, it is now considered to be a relevant objective in reducing the prevalence and consequences of atherosclerotic diseases such as PAD. Finally, efforts must be made towards addressing this very important objective, and consequently a greater number of studies need to be made in combatting phlogosis, especially among PAD patients.
Keywords: Peripheral arterial disease, phlogosis, biomarkers, medical therapy, inflammation, inflammatory biomarkers, atherosclerotic diseases, T-lymphocytes, C-reactive protein (CRP), Metalloproteinase (MMPS)
Current Pharmaceutical Design
Title:Inflammation in Peripheral Arterial Disease (PAD)
Volume: 18 Issue: 28
Author(s): Salvatore Santo Signorelli, Massimiliano Anzaldi and Valerio Fiore
Affiliation:
Keywords: Peripheral arterial disease, phlogosis, biomarkers, medical therapy, inflammation, inflammatory biomarkers, atherosclerotic diseases, T-lymphocytes, C-reactive protein (CRP), Metalloproteinase (MMPS)
Abstract: Peripheral arterial disease (PAD) affects a large number of individuals over the age of 55 years old, and data from studies has shown a relationship between inflammation, and PAD. Many researchers have not only focused on the role played by inflammatory biomarkers and the progression of PAD, but also on the efficiency of biomarkers in monitoring medical, surgical and interventional strategies in PAD patients. In this review, Authors aim to demonstrate that biomarkers play a key role in the pathophysiology of PAD, and consequently they could be screened to highlight individuals showing these crucial pathophysiological signs. Based on a large debate about phlogosis, it is now considered to be a relevant objective in reducing the prevalence and consequences of atherosclerotic diseases such as PAD. Finally, efforts must be made towards addressing this very important objective, and consequently a greater number of studies need to be made in combatting phlogosis, especially among PAD patients.
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Cite this article as:
Santo Signorelli Salvatore, Anzaldi Massimiliano and Fiore Valerio, Inflammation in Peripheral Arterial Disease (PAD), Current Pharmaceutical Design 2012; 18 (28) . https://dx.doi.org/10.2174/138161212802481273
DOI https://dx.doi.org/10.2174/138161212802481273 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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